4I16


Conserved Protein Domain Family
CARD_CARD11_CARMA1

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cd08808: CARD_CARD11_CARMA1 
Click on image for an interactive view with Cn3D
Caspase activation and recruitment domain of CARD11-like proteins
Caspase activation and recruitment domain (CARD) similar to that found in CARD11, also known as caspase recruitment domain-containing membrane-associated guanylate kinase protein 1 (CARMA1). CARMA1, together with BCL10 (B-cell lymphoma 10) and Malt1 (mucosa-associated lymphoid tissue-lymphoma-translocation gene 1), form the L-CBM signalosome (CBM complex in lymphoid immune cells) which mediates activation of NF-kB and MAPK by ITAM-coupled receptors expressed on immune cells. CARMA1 associates with BCL10 via a CARD-CARD interaction. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 260070
Aligned: 5 rows
Threshold Bit Score: 179.047
Created: 17-Feb-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative BCL10
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative BCL10 interaction site [polypeptide binding site]
Evidence:
  • Structure:4I16: mouse CARMA1-CARD binds sulfate ions, contacts at 4A.
    View structure with Cn3D
  • Comment:A conserved cluster of positive charges stabilized by two sulfate ions in the crystal structure.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #  #  #                           #  #                             
4I16_A       5 LWDNVECNRHMLSRYINPAKLTPYLRqcKVIDEQDEDEVLNAPMLpsKINRAGRLLDILHTKGQRGYVVFLESLEFyYPE 84   house mouse
CAF95531    12 LWEKVECKRFELCRIISPAKLTPYLRqcKVLDEQDEDEILNSILLvsKANRTSRLLDILHTKGERGYVAFLESLEFyYPD 91   spotted green pu...
AAG53402    15 LWENVECNRHMLSRYINPAKLTPYLRqcKVIDEQDEDEVLNAPMLpsKINRAGRLLDILHTKGQRGYVVFLESLEFyYPE 94   human
Q8CIS0      22 LWDNVECNRHMLSRYINPAKLTPYLRqcKVIDEQDEDEVLNAPMLpsKINRAGRLLDILHTKGQRGYVVFLESLEFyYPE 101  house mouse
CAG32725    24 LWENVECNRHMLSRYINPAKLTPYLRqcKVIDEQDEDEVLNSLMLpsKINRAGRLLDILHTKGQRGYVVFLESLEFyYPE 103  chicken
Feature 1            
4I16_A      85 LYKLVT 90   house mouse
CAF95531    92 LYKLVT 97   spotted green pufferfish
AAG53402    95 LYKLVT 100  human
Q8CIS0     102 LYKLVT 107  house mouse
CAG32725   104 LYKLVT 109  chicken

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