2CY4,2CY5


Conserved Protein Domain Family
PTB_EPS8

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cd01210: PTB_EPS8 
Click on image for an interactive view with Cn3D
Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
EPS8 is a regulator of Rac signaling. It consists of a PTB and an SH3 domain. PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lack tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains. This cd is part of the Dab-like subgroup.
Statistics
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PSSM-Id: 269921
Aligned: 55 rows
Threshold Bit Score: 137.678
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeputative
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative phosphoinositide binding site [chemical binding site]
Evidence:
  • Comment:based on the phosphoinositide binding site of Dab1
  • Comment:this is in a similar region as the phosphoinositide binding site found in PH domains.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                                                        
2CY4_A         7 DVSQYHVNHLVTFCLGEEdgVHTVEDASRKLAVXDSQGRVWAQEXLLRVSPSQVTLLDPVSkEELESYPLDAIVRCDAVX 86  house mouse
AAF55374      23 VKPTYALEHLATFKLKNEaeVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDM-KEIENFPGSLITEPTAFI 101 fruit fly
NP_001041048  99 VTPSYYVEHLATFAVGRQfgLTFPADGIRKLKQMEKNSAIWAQPLILRFRHNAVTVEDDNG-ELVEQFPLELIEQPTAHV 177 nematode
XP_001990784  25 HKPTYALDHLATFKLKTEaeTKQPKDKMKLLIELDKTGGIWPHKMYMSFNGQWLVMLDQDM-KEIENFPGSLITEPTAFI 103 Drosophila grim...
XP_001998229  25 SKPTYALDHLVTFKLKNEaeVKQPKEKMKLLIELDKTGGIWPHKMYMCFNGQWLLMLNKDM-KEIENFPGSLITEPTAFI 103 Drosophila moja...
XP_002433601   2 DGPSYLLEHLATFSVGQQyaLESPKDGLRKLFQMEKSKGIWTQKMKMKLDRKWVIIIDCENgDIVERFPMSLISDPTAFT 81  black-legged tick
EFX72825      30 DGPSFVVEHLATFTVSQQneVMYPADGMRRLLHMEKTSGIWTQKMILRLDREWVTIQDFENgEVVERFPLNLILEPTAFT 109 common water flea
ADY40622      89 DSPSYWVEHLATFAVGREfgLQFPSDGVRKLKQLEKNSAIWAQPMVLRLRPNMVSVEDENG-DLVEQFPMELVTDPSAHL 167 pig roundworm
XP_003737051  56 HGPSYLVEHLATFRVGSAyeVESPKDGLRKLFQMEKTKGIWTQKMSIRLEPRWMVIIDEENgEIVERFPMSLISEPTAFT 135 western predato...
EFO24103      71 DTPSYWVEHLATFAVGREfgLQYPEDGVRKLKQLEHSSAIWAQPMVLRLQPRLVSVEDENG-DLVEQFPMELVTNPTAHL 149 Loa loa
Feature 1                 #                        #                        
2CY4_A        87 Prg---rSRSLLLLVCQEPEr-----aQPDVHFFQGLLLgAELIREDIQGALQNYRSGR 137 house mouse
AAF55374     102 SdhpqesFNNILIFSVPGISl-----gNTEMHIFQVADVsSVLLVEDLKTLSKGTPVTV 155 fruit fly
NP_001041048 178 SndsretYNNVLLFVVREDRkrm--stPTEMHIFQCIRVsATDVAEDLKNYVQGQFRRV 234 nematode
XP_001990784 104 SddpletYNNVLVFSVPGISl-----gNTEMHIFQVTDVnSVHLVEDLRLLSSGSQVTM 157 Drosophila grimshawi
XP_001998229 104 SddpletYNNILIFSVPGISl-----gNTEMHIFQVTDVsAVHLVEDLRKLSSGSPVTV 157 Drosophila mojavensis
XP_002433601  82 SddprelYNNILVFVVQDDHtsg-qqvHAEMHIFQCVRIsAQEVVDDIKAFIMGKPGGG 139 black-legged tick
EFX72825     110 SldpkdlYNNIFIFVVGEDPln---rdPPEMHIFQCVGVsSELVTEDMKMYMAGNYRPS 165 common water flea
ADY40622     168 StdprdvYNNILLFIVQEDKrrgrsvaPTEMHIFQCNRVsANDVVEDMRAYLTGQYQRV 226 pig roundworm
XP_003737051 136 SndprelYNNILVFIVKDDQpkg-atsDAEMHIFQCVRIsAQEVVSDVKGLMLGKGLPK 193 western predatory mite
EFO24103     150 StnprdvYNNILLFIVKEDKkrgrslnPTEMHIFQCNRVsANDVVDDIKAFLSGHYKKV 208 Loa loa

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