Conserved Protein Domain Family
PH_PLEKHG5_G6

?
cd13244: PH_PLEKHG5_G6 
Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
PLEKHG5 has a RhoGEF DH/double-homology domain in tandem with a PH domain which is involved in phospholipid binding. PLEKHG5 activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in PLEKHG5 are associated with autosomal recessive distal spinal muscular atrophy. PLEKHG6 (also called MyoGEF) has no known function to date. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Statistics
?
PSSM-Id: 270064
Aligned: 22 rows
Threshold Bit Score: 107.312
Threshold Setting Gi: 241653331
Created: 2-Sep-2012
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q66T02        653 RQLLLEGSLRMKEgkd--skmDVYCFLFTDLLLVTKavk----kaeRTKVIRPPlLVDKIVCrelr-dpgSFLLIYLnef 725  house mouse
XP_002424833  519 RSLLFESDVKYKDamts-skiEVHAFLFTDFLLITKpvkrlgesriKFKIIRQPyVIDHLVTqeitrdppSLACVYLsiy 597  human body louse
XP_002590453  724 RYLLYEGPMKLKDgkd--skvDVYGFLFTDMLLITKpikr---gseKFKVIKQPmIMDRIVLrelk-dpgSFLLVYLney 797  Florida lancelet
EFA04307     1183 RHLLLEGDLKLKDtga--sklEVHCFLLTDMLLICKpstk--kggaTMRVVRQPyLVDRLVVselqretpSLAIIYKnef 1258 red flour beetle
EKC39660      491 RTLIMQSVLKLKDst----rmDVECLLFTDLLLICKpsk----rmeKYKIIKPPmRVDRMIIqelk-dkgSFLLIYLney 561  Crassostrea g...
XP_001849551  646 RKLFLEGDLKFKDslg---kmDVHCFLLTDFLLVCKknk-----heNLKVVRQPyMTDRLSVqik---eqTLYCCYLnel 714  southern hous...
EFZ22801      367 RTLLREGDLKLRDast--skmEVHVLLLTDMLLICKpst-----kkMLKIIRQPyVVDRIRIhevk-epsSLGLVYLney 438  red fire ant
XP_001631671  663 RCVIHEGPLRLVEkqg---kmDVHVFLFTDLLLITKpkk-----adKYRVIKPPmMVDKLYVhask-dpgTFLLVYVney 733  starlet sea a...
AAM11296      114 RHLFMEGDHKFKDnlg---ksDVHCFLLTDLLLVCKtiak--rglgALKVIRQPyLTDQLIVqla--pnnTLNCVYLnef 186  fruit fly
XP_003743004  545 RHLLAEVPNIKLRdasssgkvDVHCLLLTDMLLICKsvgr--kghdKLKVIRQPfVVDRIVVrdl--rdaSLLLVYMsey 620  western preda...
Q66T02        726 hsavGAYTFQASsq--alCRSWVDTIYN 751  house mouse
XP_002424833  598 --rtACTAFMLScgeselVRNWSDAIKK 623  human body louse
XP_002590453  798 nlatAAYMMQAVtp--gkGKSWIEAIRN 823  Florida lancelet
EFA04307     1259 dmavAAFILQNNda--kkIKGWKDGIAK 1284 red flour beetle
EKC39660      562 hvpvSAFTFHADqa---sIRVWVEHIRK 586  Crassostrea gigas
XP_001849551  715 smvvAAFTLQCSk-----AQSWYDSITK 737  southern house mosquito
EFZ22801      439 gtvsAALILSAGdp--klAKSWMESLKQ 464  red fire ant
XP_001631671  734 ntvvHAFALQGSna---dQTQWMDAIRK 758  starlet sea anemone
AAM11296      187 qvatTAFTLQCTe-----VKNWYDALWR 209  fruit fly
XP_003743004  621 --rvATSYLQLFgqe-mtLRIFTEQLKK 645  western predatory mite
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap