Conserved Protein Domain Family
PH2_ARAP

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cd13254: PH2_ARAP 
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
ARAP proteins (also called centaurin delta) are phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating proteins that modulate actin cytoskeleton remodeling by regulating ARF and RHO family members. They bind phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding. There are 3 mammalian ARAP proteins: ARAP1, ARAP2, and ARAP3. All ARAP proteins contain a N-terminal SAM (sterile alpha motif) domain, 5 PH domains, an ArfGAP domain, 2 ankyrin domain, A RhoGap domain, and a Ras-associating domain. This hierarchy contains the second PH domain in ARAP. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Statistics
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PSSM-Id: 270074
View PSSM: cd13254
Aligned: 6 rows
Threshold Bit Score: 154.496
Threshold Setting Gi: 194381278
Created: 23-Apr-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAG58593       52 PQPPRPLRTGMLElrGHKAKVFAALSPGELALYKSEQAFSLGIgiCFIELQGCSVRETKS---RSFDLLTPHRCFSFTAE 128  human
XP_001374806  583 SRAVLPEKCGYLElrGYKAKIFTALNGSNVWLCKNEQDFKSGLgiTVIPMNLANVKHVDRtvkQSFEIITPYRSFSFTAE 662  gray short-ta...
XP_003228417  122 GSFEAVDKCGPLElrGYKSKLYVAVAGDKVFLYKNAEEFRLGIgiTYIEMNVGNVKDVDR---RGFDLTTPYRIFSFLAD 198  green anole
CAF90404      126 GPGPHCQKQGVLElkGTKSKVYAAIITEEIWLYKSEQCFRNGIgiTLIEAHGATIRDGKP---KSFDLITPHRTFSFTAE 202  spotted green...
Q4LDD4        438 RGSEQPDRAGSLElrGFKNKLYVAVTGDKVQLYKNLEEFHLGIgiTFIDMNVGNVKEVDR---RSFDLTTPYRIFSFSAD 514  house mouse
XP_688145     517 PRKNNTNKSGYVElrGLKGRVYLSLMGTCFRLCKTDQDFNAGLaiAVVDLTAACVKQFER---KGLEITTPFKSFCFTVE 593  zebrafish
BAG58593      129 SGGARQSWAAALQ 141  human
XP_001374806  663 SEKEKQEWIEAVQ 675  gray short-tailed opossum
XP_003228417  199 TDQEKEDWVEAMR 211  green anole
CAF90404      203 SERDKRDWMEALQ 215  spotted green pufferfish
Q4LDD4        515 SELEKEQWLEAMQ 527  house mouse
XP_688145     594 SEHERDEWIEAVQ 606  zebrafish
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