Conserved Protein Domain Family
PH3_ARAP

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cd13256: PH3_ARAP 
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
ARAP proteins (also called centaurin delta) are phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating proteins that modulate actin cytoskeleton remodeling by regulating ARF and RHO family members. They bind phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding. There are 3 mammalian ARAP proteins: ARAP1, ARAP2, and ARAP3. All ARAP proteins contain a N-terminal SAM (sterile alpha motif) domain, 5 PH domains, an ArfGAP domain, 2 ankyrin domain, A RhoGap domain, and a Ras-associating domain. This hierarchy contains the third PH domain in ARAP. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Statistics
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PSSM-Id: 270076
View PSSM: cd13256
Aligned: 8 rows
Threshold Bit Score: 177.263
Threshold Setting Gi: 189527791
Created: 20-Apr-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4LDD4        745 TVSHSGFLYKTASagkplq--drrarEEFSRRWCVLSdGVLSYYENERAVTPNGEIRASEIVCLAVSPLdth-------g 815  house mouse
XP_003449363  893 SVSHNGFLFKTGSmarpvt--erkakEEFSRRWCTLNdGVFSYYESDKNSNPNGALKASEIVCLAVDNDdkh-------g 963  Nile tilapia
AAI50259      822 STFLCDFLYQAPSaaskls-sekkllEETNKKWCVLEgGFLSYYENDKSTTPNGTININEVICLAIHKEdfyl----ntg 896  human
CAF95237      269 SLFMDGFLYISSReakttl--drrgrDDMTRRWCTLEgGFLSYYDSERSPAAIGRVDVGEVVSLAVNNTetmt----gag 342  Tetraodon nig...
XP_003228417  368 SVAHNGFLYKAPSmaklvh--erkarEEFSRRWCHLHdGIFSYYESNTSTVPNGEMRVQEIVSLVHNPIdah-------g 438  green anole
XP_687312     824 PILYSGFLYKSGSlnkgtl-srrtrdADFQKYWCSVE-KSILFYESDRCHEPSMKIDVKDIICLGVSRPdssnnsgfidk 901  zebrafish
Q96P48        743 TVSHSGFLYKTASagkllq--drrarEEFSRRWCVLGdGVLSYFENERAVTPNGEIRASEIVCLAVPPPdth-------g 813  human
Q8WWN8        676 RATYSGFLYCSPVsnkagpspprrgrDAPPRLWCVLG-AALEMFASENSPEPLSLIQPQDIVCLGVSPPptdp----gdr 750  human
Q4LDD4        816 fEHTFEVYTEGERLYLFGLENAELAHEWVKCIAKAF 851  house mouse
XP_003449363  964 yDCTFEIYSESERLYLFGTDDSEVRSQWVKSIAKTF 999  Nile tilapia
AAI50259      897 pIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHF 932  human
CAF95237      343 vVFTIELYLQTERVLTVGAETQETQHDWFQALTKRF 378  Tetraodon nigroviridis
XP_003228417  439 fTSTFEVYVESERLYLFGLDNPEGIKEWVKCIAKSF 474  green anole
XP_687312     902 fRYTFELYLMSDKLVQFGLETPDALHSWARAIGKAT 937  zebrafish
Q96P48        814 fEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAF 849  human
Q8WWN8        751 fPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWF 786  human
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