Conserved Protein Domain Family
PI3Kc_C2_gamma

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cd05177: PI3Kc_C2_gamma 
Catalytic domain of Class II Phosphoinositide 3-kinase gamma
PI3Ks catalyze the transfer of the gamma-phosphoryl group from ATP to the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives. The class II gamma isoform, PI3K-C2gamma, is expressed in the liver, breast, and prostate. PI3Ks play an important role in a variety of fundamental cellular processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, immune cell activation and apoptosis. They can be divided into three main classes (I, II, and III), defined by their substrate specificity, regulation, and domain structure. Class II PI3Ks preferentially use PtdIns as a substrate to produce PtdIns(3)P, but can also phosphorylate PtdIns(4)P. They function as monomers and do not associate with any regulatory subunits. Class II enzymes contain an N-terminal Ras binding domain, a lipid binding C2 domain, a PI3K homology domain of unknown function, an ATP-binding cataytic domain, a Phox homology (PX) domain, and a second C2 domain at the C-terminus. It's biological function remains unknown. The PI3K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Statistics
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PSSM-Id: 270721
View PSSM: cd05177
Aligned: 3 rows
Threshold Bit Score: 696.641
Threshold Setting Gi: 47224471
Created: 9-Aug-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                            # ### #   
CAG08721   313 RKELQLETRLTSALIQAAEKIRTAEKTRRKNILKREASQIEDFFKdGVSCCLPLDPAVRVKGLDAEACKVYNSNAAPLGI 392  Tetraodon nigrov...
O75747     825 NDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQdVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKI 904  human
XP_416412  793 NNEFSKEEKLIRILEDTAEKVKVASDAKRKEVLKMELNRLQQFFQeVKVCRLPLNPALVVQGIEADSCSYFTSNAFPLKI 872  chicken
Feature 1                    # #  #                              #           ####    #  #      
CAG08721   393 SFICtdplaknVSVICKTGDDLQQDMLILQIVRMMDRVWLQEGLDLQMITYRCLSTGKTQGLVEVVPDAVTLGKIQQEWG 472  Tetraodon nigrov...
O75747     905 TFINanpmgknISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSG 984  human
XP_416412  873 RFINanapsgnINIIFKIGDDLRQDMLVLQIVRVMDNIWLQEGLDMQMIIYRCLSTGKGQGLVQMVPDATTLAKIHRESG 952  chicken
Feature 1                                                           # #         ##             
CAG08721   473 LAGSLREDTLEKWFHMWNktkedYDKAVMNFIHSCAGWCVATFILGICDRHNDNIMLKHSGHMFHIDFGKIMGNAQKFGS 552  Tetraodon nigrov...
O75747     985 LIGPLKENTIKKWFSQHNhlkadYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGG 1064 human
XP_416412  953 LIGPLKENTIRKWFRHHHrlessYQEAIRNFFHSCAGWCVVTFILGVCDRHNDNIMLTNSGHMFHIDFGRFLGHAQTFGS 1032 chicken
Feature 1                                                                                      
CAG08721   553 FKRDRSPFIFTSEMQHSHHRWGQKPQRLHRFVELCCEAYNIVRQRSALILGLLELMLHAGMPELkdINDLQYVQNNLRPh 632  Tetraodon nigrov...
O75747    1065 IKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELsgIQDLKYVYNNLRPq 1144 human
XP_416412 1033 IRRDRAPFIFTSEMEYFITEGGKSPQRFQEFVELCCRAYNIVRKHSQLLLNLLEMMLHAGLPELnsIQDLKYVYDNLRPq 1112 chicken
Feature 1                                        
CAG08721   633 dtDLEATSYFTKKIKESMSSvAVKINFLTHSMAQ 666  Tetraodon nigroviridis
O75747    1145 dtDLEATSHFTKKIKESLECfPVKLNNLIHTLAQ 1178 human
XP_416412 1113 dsDLQATSYFTRKIKESLECfPVKLNNLIHTLAH 1146 chicken

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