1FGI,1CJA,1F3M,2PHK,1J7U,1E8X,1ZP9


Conserved Protein Domain Family
PKc_like

?
cd13968: PKc_like 
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Kinase superfamily
The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.
Statistics
?
PSSM-Id: 270870
Aligned: 8 rows
Threshold Bit Score: 90.194
Threshold Setting Gi: 5542182
Created: 20-Sep-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
ATP binding
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1     ####   # #                    # #                                               
1FGI_A     29 LGEGa-fGQVVLAEaigldkd-kpnrvtKVAVKMLksdate-----------------------kdlsdlISEMEMMKMI 83   human
1CJA_A     77 SEKGt--EGLFFVEte----------sgVFIVKRStn--------------------------------iESETFCSLLC 112  slime mold
1F3M_C     28 IGQGa-sGTVYTAMdva--------tgqEVAIRQMnlqqqp------------------------kkeliINEILVMREN 74   human
2PHK_A     12 LGRGv-sSVVRRCIhkp--------tckEYAVKIIdvtgggsfsa---------------eevqelreatLKEVDILRKV 67   Oryctolagus cunic...
1J7U_B     22 DTEGmspAKVYKLVge----------neNLYLKMTdsrykg------------------------ttydvEREKDMMLWL 67   Enterococcus faec...
1E8X_A    663 MASK---KKPLWLEfkcadptalsnetiGIIFKHGdd--------------------------------lRQDMLILQIL 707  pig
1ZP9_A     55 ISTGk-eANVFYADgvfd------gkpvAXAVKIYrietsefdkxdeylygderfdxrrispkekvfiwtEKEFRNLERA 127  Archaeoglobus ful...
NP_064632 349 MKGG---REVAMKIqy-----------pGVAQSINsdvnnlmavln-------------msnmlpeglfpEHLIDVLRRE 401  human
1CJA_A     77 SEKGt--EGLFFVEte----------sgVFIVKRStn--------------------------------iESETFCSLLC 112  slime mold
1F3M_C     28 IGQGa-sGTVYTAMdva--------tgqEVAIRQMnlqqqp------------------------kkeliINEILVMREN 74   human
2PHK_A     12 LGRGv-sSVVRRCIhkp--------tckEYAVKIIdvtgggsfsa---------------eevqelreatLKEVDILRKV 67   Oryctolagus cunic...
1J7U_B     22 DTEGmspAKVYKLVge----------neNLYLKMTdsrykg------------------------ttydvEREKDMMLWL 67   Enterococcus faec...
1E8X_A    663 MASK---KKPLWLEfkcadptalsnetiGIIFKHGdd--------------------------------lRQDMLILQIL 707  pig
1ZP9_A     55 ISTGk-eANVFYADgvfd------gkpvAXAVKIYrietsefdkxdeylygderfdxrrispkekvfiwtEKEFRNLERA 127  Archaeoglobus ful...
NP_064632 349 MKGG---REVAMKIqy-----------pGVAQSINsdvnnlmavln-------------msnmlpeglfpEHLIDVLRRE 401  human
Feature 1                             #                                        ####           
1FGI_A     84 gkh------------------kniINLLGACtqd-------------------------gpLYVIVEYAskgnlreylqa 120  human
1CJA_A    113 mrlg-----------------lhaPKVRVVSsnseegtnmleclaaidksfrvittlanqaNILLMELVrgitlnklt-- 173  slime mold
1F3M_C     75 knp-------------------niVNYLDSYlvg-------------------------deLWVVMEYLaggsltdvvt- 109  human
2PHK_A     68 sgh------------------pniIQLKDTYetn-------------------------tfFFLVFDLMkkgelfdylt- 103  Oryctolagus cunic...
1J7U_B     68 egk------------------lpvPKVLHFErhd-------------------------gwSNLLMSEAdgvlcsee--- 101  Enterococcus faec...
1E8X_A    708 rimesiwet------esldlcllpYGCISTGd-----------------------------KIGMIEIVkdattiakiqq 752  pig
1ZP9_A    128 keag-----------------vsvPQPYTYXk-----------------------------NVLLXEFIgedelpaptlv 161  Archaeoglobus ful...
NP_064632 402 lalecdyqreaacarkfrdllkghPFFYVPEivde----------------------lcspHVLTTELVsgfpldqae-- 457  human
1CJA_A    113 mrlg-----------------lhaPKVRVVSsnseegtnmleclaaidksfrvittlanqaNILLMELVrgitlnklt-- 173  slime mold
1F3M_C     75 knp-------------------niVNYLDSYlvg-------------------------deLWVVMEYLaggsltdvvt- 109  human
2PHK_A     68 sgh------------------pniIQLKDTYetn-------------------------tfFFLVFDLMkkgelfdylt- 103  Oryctolagus cunic...
1J7U_B     68 egk------------------lpvPKVLHFErhd-------------------------gwSNLLMSEAdgvlcsee--- 101  Enterococcus faec...
1E8X_A    708 rimesiwet------esldlcllpYGCISTGd-----------------------------KIGMIEIVkdattiakiqq 752  pig
1ZP9_A    128 keag-----------------vsvPQPYTYXk-----------------------------NVLLXEFIgedelpaptlv 161  Archaeoglobus ful...
NP_064632 402 lalecdyqreaacarkfrdllkghPFFYVPEivde----------------------lcspHVLTTELVsgfpldqae-- 457  human
Feature 1                                                                                     
1FGI_A    121 rrppgle-------ysynpshnpeeqlsskdlVSCAYQVARGMEYLAsk------------------------------- 162  human
1CJA_A    174 -----------------------ttsapevltKSTMQQLGSLMALDVi-------------------------------- 198  slime mold
1F3M_C    110 -----------------------etcmdegqiAAVCRECLQALEFLHsn------------------------------- 135  human
2PHK_A    104 ----------------------ekvtlseketRKIMRALLEVICALHkl------------------------------- 130  Oryctolagus cunic...
1J7U_B    102 -------------------------yedeqspEKIIELYAECIRLFHsidisdcpytnsldsrlaeldyllnndladvdc 156  Enterococcus faec...
1E8X_A    753 stvgntgafkdevlshwlkekcpieekfqaavERFVYSCAGYCVATFv-------------------------------- 800  pig
1ZP9_A    162 ---------------------elgrelkeldvEGIFNDVVENVKRLYqe------------------------------- 189  Archaeoglobus ful...
NP_064632 458 ------------------------glsqeirnEICYNILVLCLRELFef------------------------------- 482  human
1CJA_A    174 -----------------------ttsapevltKSTMQQLGSLMALDVi-------------------------------- 198  slime mold
1F3M_C    110 -----------------------etcmdegqiAAVCRECLQALEFLHsn------------------------------- 135  human
2PHK_A    104 ----------------------ekvtlseketRKIMRALLEVICALHkl------------------------------- 130  Oryctolagus cunic...
1J7U_B    102 -------------------------yedeqspEKIIELYAECIRLFHsidisdcpytnsldsrlaeldyllnndladvdc 156  Enterococcus faec...
1E8X_A    753 stvgntgafkdevlshwlkekcpieekfqaavERFVYSCAGYCVATFv-------------------------------- 800  pig
1ZP9_A    162 ---------------------elgrelkeldvEGIFNDVVENVKRLYqe------------------------------- 189  Archaeoglobus ful...
NP_064632 458 ------------------------glsqeirnEICYNILVLCLRELFef------------------------------- 482  human
Feature 1                                      #            ## #          ##  
1FGI_A    163 ----------------------------kCIHRDL---------AARNVLVted-nvMKIADFG 188  human
1CJA_A    199 -----------------------------VNNSDRlpiawtnegNLDNIMLsergatVVPIDSK 233  slime mold
1F3M_C    136 ----------------------------qVIHRDI---------KSDNILLgmd-gsVKLTDFG 161  human
2PHK_A    131 ----------------------------nIVHRDL---------KPENILLddd-mnIKLTDFG 156  Oryctolagus cuniculus
1J7U_B    157 enweedtpfkdprelydflktekpeeelvFSHGDL---------GDSNIFVkdg-kvSGFIDLG 210  Enterococcus faecalis
1E8X_A    801 -----------------------------LGIGDR---------HNDNIMIset-gnLFHIDFG 825  pig
1ZP9_A    190 ---------------------------aeLVHADL---------SEYNIXYid---kVYFIDXG 214  Archaeoglobus fulgidus
NP_064632 483 ----------------------------hFMQTDP---------NWSNFFYdpqqhkVALLDFG 509  human
1CJA_A    199 -----------------------------VNNSDRlpiawtnegNLDNIMLsergatVVPIDSK 233  slime mold
1F3M_C    136 ----------------------------qVIHRDI---------KSDNILLgmd-gsVKLTDFG 161  human
2PHK_A    131 ----------------------------nIVHRDL---------KPENILLddd-mnIKLTDFG 156  Oryctolagus cuniculus
1J7U_B    157 enweedtpfkdprelydflktekpeeelvFSHGDL---------GDSNIFVkdg-kvSGFIDLG 210  Enterococcus faecalis
1E8X_A    801 -----------------------------LGIGDR---------HNDNIMIset-gnLFHIDFG 825  pig
1ZP9_A    190 ---------------------------aeLVHADL---------SEYNIXYid---kVYFIDXG 214  Archaeoglobus fulgidus
NP_064632 483 ----------------------------hFMQTDP---------NWSNFFYdpqqhkVALLDFG 509  human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap