Conserved Protein Domain Family
NHL_like_2
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cd14957: NHL_like_2 
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins
The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Links
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Statistics
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PSSM-Id: 271327
Aligned: 21 rows
Threshold Bit Score: 297.64
Created: 21-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:NHL repeat [structural motif]
Evidence:
  • None
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              ####### #####################   ##########                 
WP_002760237   45 ASFSFAFGSEGSGNGQFMl--PRGIAAGrGGNIYVADTDNNRVQVFNSSGv--FQSAFGSQGSGn--gQFRSPYGIAVS- 117  Microcystis a...
WP_007401221   28 DPTYVSTIGIGNGIGDYEfafPVDVAVDsAGDIYVGDQQNNRIQIFDSAGv--YKSTIGNGLTPe--yQFDFPAGVAVD- 102  Candidatus Ni...
ETR70408      762 YSIGLDDANTGSGPGEFDy--PYFLTMDdAGILYVSDTYNNRIQLFTTEGq--YIKSIGSSGTG----AGEFDESNGIAv 833  Candidatus Ma...
YP_685830     109 AASNGTLGSRGNGNYQFNg--PFDVEVGvDGKIYVADHGNNRVQVYSDTGa--YLLTVGSGPGSgd-sQFDRPMSVAVD- 182  Methanocella ...
ETR65320       28 YSFSYSFGENGSAVSQFNl--PNGIAVDsAGNIYVSDCFNHRIQVFTSSGa--FSYSVGSGSASadpgKFNYPRGIHID- 102  Candidatus Ma...
ETR69369      591 GTPIYRISKNSYQQGAVSd--PIDVDVDdDGNIYVIENGGNRLSVFTSDRe--FAYSIGTGDMTs--dIGGFNYPMDVDv 664  Candidatus Ma...
ETR68080      528 FAYSIGTGDSSSLTGCFAy--PMDVDVS-NGKIYVADSNNTRIQVFNSASgayEYSIGGNWGNGp--ySFDWISGLGVDd 602  Candidatus Ma...
YP_005442343  295 AGTLGTTGSPGSGNNRFDt--PQGVAVD-ANYIYVADTENHRVQIFNRNTlayVATIGGSYGTGn--nQFKFPTDVAVD- 368  Caldilinea ae...
ETR66005      143 DSASLAFSITGSEIGSFDa--IHGIAIDsKDNIYVSDLNNNRIQVFTSSGd--YSYSLGTGFDGsgtdDINGPAGIAID- 217  Candidatus Ma...
ETR66930      359 FDFQIGTGSFGSGNGEFNt--PREVAINsAGKIYVVDTNNHRVQIFSSTGv--YESKFGSGSIStndgEFYSPSSIKID- 433  Candidatus Ma...

Feature 1                                                                                         
WP_002760237  118 RSGNIYVADtdNNRVQVFNSSGVf-qSAFGSQGTvngq----fqgPYAIAVGSS-GNVYVADtgNFRVQVFNSNGg-FQF 190  Microcystis a...
WP_007401221  103 SAGDIYVADvfNSRIQIFDSAGVy-kSTIGVTGEpgsdd-dhfedPDGIAVDSA-GDIYVVDpsNNRIQIFDSAGv-YKS 178  Candidatus Ni...
ETR70408      834 HDSKIYVVDqkNHRVQVLNADSGvfdYSIGTGTSgsnpg--efdsPSGIAVDNN-GKIYVADsrNHRVQVFSASGs-FEY 909  Candidatus Ma...
YP_685830     183 SAGSIYVADymNNKVKIFDGAGTy-lRSIGTGTLgtgdy--efrrPKGVTVDGS-GNVYVVDgyNNRIQVFDSAGt-YLR 257  Methanocella ...
ETR65320      103 DSGKIYVADddNNRIQVFTSAFEy-dYSITTGGD-----------PQDVFVDSN-GKVYVANndGSVVQVYTSDGn-LDF 168  Candidatus Ma...
ETR69369      665 SNGKIYVADsnNTRIQVFNSASGayeYSIGGNWGngpy---sfdwISGLGVDDNtGKLYVSDeaNNIIRVYSSSGt-FEY 740  Candidatus Ma...
ETR68080      603 NTGKLYVSDeaNNIIRVYSSSGVf-eYTIGTGSNgdgpg--dlnePQCITIDDD-SNVYVPEagNHRISVFTSDGt-FQY 677  Candidatus Ma...
YP_005442343  369 AAGNIYVADyaNKRVQQYNSSRIy-qRTYGTTGVsyvasndrfyyPEGVAVGPD-GSIYVVEgyGHRLVKLNAAGv-PQW 445  Caldilinea ae...
ETR66005      218 SDDNIYIAEkeGNRIHGFNAQGT---TILNMTNDfs--------gPYGIAVDNDgTNMYVADtsNDIVKICTCPFacNCN 286  Candidatus Ma...
ETR66930      434 SDGKIYIADsqNSRIQVFSSTNVf-eYSIGSNGSgdgq----fnvVNQIAFDST-GKLFATDynNNRIQVFTKSGt-FLY 506  Candidatus Ma...

Feature 1                                                                                         
WP_002760237  191 AFGSfgtg----dgqFQGSYGIAVGSSGHVYVADTf---------NNRVQVFDDRGvFQFAFGSQgsg------ngeFES 251  Microcystis a...
WP_007401221  179 TIGNgltp----eyqFDFPEGVAVDSAGDIYVADQg---------NNRIQIFDSAGvYKSTIGNGltp------eyqLSG 239  Candidatus Ni...
ETR70408      910 SIGTgiags--nageFNRPYDVYVDSAGKIYVTDQs---------NSRVQIFSASGeYVNSFGSSgqg------pgeFGS 972  Candidatus Ma...
YP_685830     258 TIGAsgfgp-sgtthFFVPKDCKVGADGTVYVADEg---------GMCVHVFSNTGaWIRTIGTPgtsgs---gnyqFNC 324  Methanocella ...
ETR65320      169 TFGSg---------eLNFPTGIAVDRDGKIYVTSNm---------ANLVKVFTNSGiADYTIGTGgpgt----adglLEG 226  Candidatus Ma...
ETR69369      741 TIGTgsngd--gpgdLNEPQCITIDDDSNIYVAEAr---------NHRISVFTSDGtFQYSVTND------------FGY 797  Candidatus Ma...
ETR68080      678 SVTHd----------FGYPREVAIDNDGNYYVIEKw---------NDRFQVFSSDWtFLYMFGGSgddtgyvenneqFMD 738  Candidatus Ma...
YP_005442343  446 TVGEagqpg-ddnahFGYLRDVAVGPDGRIYTIEAwgsaryapggNHRLQIFNPDGsYYGGFGGYgsg------nyqFIA 518  Caldilinea ae...
ETR66005      287 EIGD-----------FRLPYGIALGSNGNIFVADTm---------NKCIRIYDNDT-LIDTIGSEgsg------pgeFSN 339  Candidatus Ma...
ETR66930      507 AFGSktlypyatlgyMSKPQGITIDRDDNVYVADY----------IRTVQKFSNDGtPVLRIAQTsfq------kggLND 570  Candidatus Ma...

Feature 1                                                                                         
WP_002760237  252 PYGIAVDSRGYIYVTDTfNDRVQVFDDRGVFqstfgsfGTGNg-----------eFSSPYGIAVGsrGNIYVADTv--NN 318  Microcystis a...
WP_007401221  240 PVGIAVDSAGDIYVADQgNNRIQIFDSAGVYk-----sTIGVtgepg---sdddhFNFPDGIAVDslGKIYVADIf--NH 309  Candidatus Ni...
ETR70408      973 PTGITIDSVGKIYVSDY-DHRIQVFSSSYAYe-----ySIGTldssl----dagkFEEPVGMFVNetGKLFVADSy--NQ 1040 Candidatus Ma...
YP_685830     325 PCDVAVDGGGNIYVADPgNDKVKIYDNTGTYl-----rSIGTgigga----gddqFDDPMSVDLDseGNIYVADRn--NN 393  Methanocella ...
ETR65320      227 PADIAINNDGKIFISDTmNERIQVFTSSGVFd-----ySIGTsgtyg---dppdqFTMPYAICLDsdGHLYVAEH---SN 295  Candidatus Ma...
ETR69369      798 PREVAIDNDGNYYVIEKwNNRFQVFSSDWTFl-----yMFGGsgydtgyvenneqFMDAYGIAVDknGYIYVADQt--NQ 870  Candidatus Ma...
ETR68080      739 AYGIAVDKNGYIYVADQsNQRVQILSGASSYyvn--naRIGIg-----------tNNPAEELEVV--GSVKIVDGnqaSG 803  Candidatus Ma...
YP_005442343  519 PHGIAIDQAGKVYIADRdNHRVQIYNSQLAYv-----aTLGQtgvpg---sdnshFNYPFDVAVDrnGIIYVADEg--ND 588  Caldilinea ae...
ETR66005      340 PRGVDVDSDGLIYVADTlNSRIQVFTASGDY-------SYSIcg----------gFSWPNCVKVHk-NKIYVGDD---YG 398  Candidatus Ma...
ETR66930      571 PIDVDVDDDGNIYVIENgGNRVSVFTSSREFa-----ySIGTgdmts----diggFNYPMDIDVSn-GKIYVADSn--NT 638  Candidatus Ma...

Feature 1               
WP_002760237  319 RVQVFR 324  Microcystis aeruginosa
WP_007401221  310 RIQIFV 315  Candidatus Nitrosoarchaeum limnia
ETR70408     1041 RIQIFQ 1046 Candidatus Magnetoglobus multicellularis str. Araruama
YP_685830     394 RIRIFY 399  Methanocella arvoryzae MRE50
ETR65320      296 RIQVYT 301  Candidatus Magnetoglobus multicellularis str. Araruama
ETR69369      871 RVQILS 876  Candidatus Magnetoglobus multicellularis str. Araruama
ETR68080      804 KVFVSD 809  Candidatus Magnetoglobus multicellularis str. Araruama
YP_005442343  589 RIQVFN 594  Caldilinea aerophila DSM 14535 = NBRC 104270
ETR66005      399 RILVFN 404  Candidatus Magnetoglobus multicellularis str. Araruama
ETR66930      639 RIQVFN 644  Candidatus Magnetoglobus multicellularis str. Araruama

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