Conserved Protein Domain Family
mtp

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TIGR00799: mtp 
Golgi 4-transmembrane spanning transporter
The proteins of the MET family have 4 TMS regions and are located in late endosomal or lysosomal membranes. Substrates of the mouse MTP transporter include thymidine, both nucleoside and nucleobase analogues, antibiotics, anthracyclines, ionophores and steroid hormones. MET transporters may be involved in the subcellular compartmentation of steroid hormones and other compounds.Drug sensitivity by mouse MET was regulated by compounds that inhibit lysosomal function, interface with intracellular cholesterol transport, or modulate the multidrug resistance phenotype of mammalian cells. Thus, MET family members may compartmentalize diverse hydrophobic molecules, thereby affecting cellular drug sensitivity,nucleoside/nucleobase availability and steroid hormone responses. [Transport and binding proteins, Unknown substrate]
Statistics
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PSSM-Id: 273274
Aligned: 4 rows
Threshold Bit Score: 250.283
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAA07643  11 RLSTVRQT-CC-CFNVRIATTALAIYHVIMSVLLFIEHSVEVAHgKASCKLSQMGYLRIADLISS-FLLITMLFIISLSL 87  human
Q60961    10 RSDRFYSTrCCgCFHVRTGTIILGTWYMVVNLLMAILLTVEVTH-PNSMPAVNIQYEVIGNYYSSeRMADNACVLFAVSV 88  house mouse
Q15012    10 RSDRFYSTrCCgCCHVRTGTIILGTWYMVVNLLMAILLTVEVTH-PNSMPAVNIQYEVIGNYYSSeRMADNACVLFAVSV 88  human
Q61168     4 RAAPVRQT-CC-CFNIRVATIALAIYHIVMSVLLFIEHVVEVARgKVSCRFFKMPYLRMADLLSS-FLLIGVLFIISISL 80  house mouse
BAA07643  88 LIGVVKNreKYLLPFLSLQIMdyllclltllgsyielpaylklasrsrassSKFPLMTLQLLDFCLSILTLCSSYMEVPt 167 human
Q60961    89 LMFIISS--MLVYGAISYQVG------------------------------WLIPFFCYRLFDFVLSCLVAISSLTYLP- 135 house mouse
Q15012    89 LMFIISS--MLVYGAISYQVG------------------------------WLIPFFCYRLFDFVLSCLVAISSLTYLP- 135 human
Q61168    81 LFGVVKNreKYLIPFLSLQIMdfllclltllgsyie-lpaylklarprpgpSKVPLMTLQLLDFCLSILTLCSSYMEVPt 159 house mouse
BAA07643 168 yLNFKSMNHMNYLPSQEDMPHNQFIKMMIIFSIAFITVLIFKVYMFKCVWRCYRLIKCMNS--VEEKRNSKMLQKVVLPS 245 human
Q60961   136 -RIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFVVFIIFKAYLINCVWNCYKYINNRNVpeIAVYPAFETPPQYVLPT 214 house mouse
Q15012   136 -RIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVpeIAVYPAFEAPPQYVLPT 214 human
Q61168   160 yLNFKSMNHMNYLPSQEGVPHSQFINMMLIFSVAFITVLILKVYMFKCVYTCYKFLKHMNS--AMEDSSSKMFLKVALPS 237 house mouse
BAA07643 246 YEEALSLPSKTPeggpaPPPYSEV 269 human
Q60961   215 YEMAVKIPEKEP-----PPPYLPA 233 house mouse
Q15012   215 YEMAVKMPEKEP-----PPPYLPA 233 human
Q61168   238 YEEALSLPPKTPegdpaPPPYSEV 261 house mouse
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