Conserved Protein Domain Family
2A060605

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TIGR00920: 2A060605 
3-hydroxy-3-methylglutaryl-coenzyme A reductase
[Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Statistics
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PSSM-Id: 273339
Aligned: 5 rows
Threshold Bit Score: 1464.69
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P16393     1 MLSRLFLAQGRFCSSHPWEVIVCTLTLTICMLS--MNYFTGLPR------------------------------------ 42   purple sea urchin
P00347     1 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMS--MNMFTGNNK------------------------------------ 42   Chinese hamster
P20715     1 MLSRLFRMHGQFVASHPWEVIVGTVTLTICMMS--MNMFTGNDK------------------------------------ 42   African clawed frog
P54960     1 MVGRLFRAHGQFCASHPWEVIVATLTLTVCMLT--VDQRP-LGL------------------------------------ 41   German cockroach
AAA28608   1 MIGPLFRAT-QFCASHPWEVIVALLTITACMLNggQEQYPGCEQrighstasaaaagsgsgagsgasgtippssmggsat 79   fruit fly
P16393    43 ------ICGWNYECApQVKESSLSSDVLVMCIMRTLAVAYLYLQFTKLRTTGSKYILGIAGLFTIFSSFLFSSAVIHLFG 116  purple sea urchin
P00347    43 ------ICGWNYECP-KFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLD 115  Chinese hamster
P20715    43 ------ICGWNYACP-KFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLD 115  African clawed frog
P54960    42 ------PPGWGHNCI--TLEEYNAADMIVMTLIRCVAVLYSYYQFCHLQKLGSKYILGIAGLFTVFSSFVFSSSVINFLG 113  German cockroach
AAA28608  80 ssrhrpCHGWSQSCD-GLEAEYNAADVILMTIVRCTAVLYCYYQFCSLHRLGSKYVLGIAGLFTVFSSFIFTTAIIKFLG 158  fruit fly
P16393   117 LELTGLNEALPFFLLLIDLTKASALTKFALSSTTQNEVVDNIARGMAILGPTITLDTVVTTLVISIGTMSSIRKMEVFCC 196  purple sea urchin
P00347   116 KELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCC 195  Chinese hamster
P20715   116 KELTGLNEALPFFLLLIDLSKASALAKFALSSNSQDEVRDNIARGMAILGPTFTLEALVECLVIGVGTMSGVRQLEIMCC 195  African clawed frog
P54960   114 SDVSDLKDALFFFLLLIDLSKATVLAQFALSSRSQDEVKHNIARGIAMLGPTITLDTVVETLVIGVGMLSGVRRLEVLCC 193  German cockroach
AAA28608 159 SDISELKDALFFLLLVIDLSNSGRLRSGAMGSN-QAEVTQNIARGLELLGPAISLDTIVVVLLVGVGTLSGVQRLEVLCM 237  fruit fly
P16393   197 FGILSLIANYFVFMTFFPACLSLVLELSNSNKYGRPVWHLGRFAEVLE--EEEdRKPNPVVQRVKMIMRTGLVLVHAHSY 274  purple sea urchin
P00347   196 FGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLE--EEE-NKPNPVTQRVKMIMSLGLVLVHAHSR 272  Chinese hamster
P20715   196 FGCMSVLANYFAFMTFFPACVSLVLELSRESREGRPIWQLSQFASVLE--EEEdNKPNPVTQRVKMIMSLGLVLVHAHSR 273  African clawed frog
P54960   194 FACMSVIVNYVVFMTFYPACLSLILELSRSGESGRPAWHDKSLIIKAL--HEEdQKPNPVVQRVKVIMSAGLMLVHAH-R 270  German cockroach
AAA28608 238 FAVLSVLVNYVVFMTFYPACLSLIFDLSRSGVDMSVVREKAKGSLPLKslTEEeQKANPVLQRVKLIMTTGLMAVHIYSR 317  fruit fly
P16393   275 WLAS----NDTELmSRDMLYDGNLLTDKKIDPTMPLWEFYATRLWPPTLDYILTAILATVLASHYIFFSDLATypEKRVS 350  purple sea urchin
P00347   273 WIADpspqNSTTE-HSKVSLGLDEDVSKRIEPSVSLWQFYLSKMISMDIEQVVTLSLAFLLAVKYIFFEQAET--ESTLS 349  Chinese hamster
P20715   274 WISEpssqNSTSIsDHEVTTMLDDMMPKRVEPSMPLWQFYLSRMVTMDVEQIITLGLALLLAVKYIFFEQTET--ESTFS 351  African clawed frog
P54960   271 WVRc---------------L------------SIALWPDLTS------LRYFCTHCDTGVSYSRWSFASEGEE--LPTVK 315  German cockroach
AAA28608 318 EVSP----AATTMvDKTLTPTLSLNVSNNRTESGEIADIIIK-WLTMSADHIVISIVLIALVVKFICFDNRD-------- 384  fruit fly
P16393   351 IMEghEVVNPGSDHEDASEVETIGTLSSSPSTSDVRVIESMTSRTQACQTDPVTASPRNSRSSSpvsshsvkPARFTIGs 430  purple sea urchin
P00347   350 LKN--PITSPVVTPKKAPDNCCRREPLLVRRSEKLSSVEEEPGVSQDRKVEVIKPLVVETESAS--------RATFVLG- 418  Chinese hamster
P20715   352 MKN--PIISPVAVQKKQIESCCRREPEQ-EKTVHVSTTEEAS--SKEETEAVIKPLPLETSP----------KAKFIVG- 415  African clawed frog
P54960   316 LVTgdSVVNSNSTDDAQLHYYIMRWLTVSADHIVILILLLALA-VKFVFFETRDELTTTRGMDGw------vEVSSPVEh 388  German cockroach
AAA28608 385 ---------PLPDQLRQSGPVAIEAKASQTTPIDEEHVEQEKDTENSAAVRTLLFTIEDQSSAN---------------- 439  fruit fly
P16393   431 SgSGSEDEEEEVIKEEEVEWVLEtelkaPRPMPELLEILN-VGKG--PNALTDDEVQLLVGAK--HIPAYKLENILDNPE 505  purple sea urchin
P00347   419 A-SGTSPPVAARTQELEIELPSE-----PRPNEECLQILEsAEKG--AKFLSDAEIIQLVNAK--HIPAYKLETLMETHE 488  Chinese hamster
P20715   416 --DSSPLELSPEDKNTMFDLPEE-----PRPLDECVRILKnPDKG--AQYLTDAEVISLVNAK--HIPAYKLETMMESPR 484  African clawed frog
P54960   389 KyVQTEQPSCSAPEQPLEEPPAS-----NRSIDECLSVCK-SDVG--AQALSDCEVMALVTSG--HIAGYQLEKVVRNPE 458  German cockroach
AAA28608 440 ---ASTQTDLLPLRHRLVGPIKP-----PRPVQECLDILNsTEEGsgPAALSDEEIVSIVHAGgtHCPLHKIESVLDDPE 511  fruit fly
P16393   506 RGVAVRRQIISKLLPITD-ALEKLPYASYDYSFVSGACCENVIGYMPVPVGVAGPLLLDGQEFQVPMATTEGCLVASTNR 584  purple sea urchin
P00347   489 RGVSIRRQLLSTKLPEPS-SLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNR 567  Chinese hamster
P20715   485 EGVAIRRQMLSDKLPQRS-ALQSLPYKNYNYSLVMGACCENVIGYMPIPVGVAGPLLLNNKEYQVPMATTEGCLVASTNR 563  African clawed frog
P54960   459 RGVGIRRQILTKTADLKD-ALDNLPYKNYDYLKVMGACCENVIGYMPVPVGVAGPLNLDGRLVHVPLATTEGCLVASTNR 537  German cockroach
AAA28608 512 RGVRIRRQIIGSRAKMPVgRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNR 591  fruit fly
P16393   585 GCRALRSAGGIHSVLIGDGMTRGPLVRLPSAQEAGAIKQWLEVPENFAAIKERFESTSRFAKLKSIQTALAGRYMFLRFK 664  purple sea urchin
P00347   568 GCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKDAFDSTSRFARLQKLHVTMAGRNLYIRFQ 647  Chinese hamster
P20715   564 GCRAIMLGGGAKSRVLADGMTRGPVVRLPTACDAAEVKAWLDSAEGFKVIKDAFDSTSRFARLGRLQNCVAGRNLYIRFQ 643  African clawed frog
P54960   538 GMRALMRCG-VTSRIVADGMTRGPVVRFPNIDRASEAMLWMQVPYNFEQIKKNFDSTSRFARLSKIHIRVAGRHLFIRFI 616  German cockroach
AAA28608 592 GCKALSVRG-VRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFV 670  fruit fly
P16393   665 ALTGDAMGMNMISKGTEQALHALQTMFPNIEIMSLSGNYCTDKKVAAINWIEGRGKSVVCEATVPAHIVQQVLKTSASAL 744  purple sea urchin
P00347   648 SKTGDAMGMNMISKGTEKALLKLQEFFPEMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAM 727  Chinese hamster
P20715   644 SKTGDAMGMNMISKVTEQALARLQEEFPDLHVLAVSGNYCTDKKPAAINWIEGRGKSVVCEAIIPAKVVREVLKSSTEAL 723  African clawed frog
P54960   617 ATTGDAMGMNMLSKGTEVALAYVQQVYPDMEILSLSGNFCTDKKPAAVNWIEGRGKSVVCEAIVPADIIKSVLKTSVQAL 696  German cockroach
AAA28608 671 AITGDRMGMNMVSKALRWPFAEFTLHFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTL 750  fruit fly
P16393   745 VDLNIHKNLVGSAMAGSIGGFNAHAANIVTAIYIATGQDAAQNIASSNCMTLMETRGPKGGDLYLSCTMPSIELGTVGGG 824  purple sea urchin
P00347   728 IDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGG 807  Chinese hamster
P20715   724 VEVNINKNFIGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITIMEATGPTYEDLYISCTMPSIEIGTVGGG 803  African clawed frog
P54960   697 MDVNITKNLIGSAVAGSIGGFNAHAANIVTAIFIATGQDPAQNVGSSNCMTLMEPWGEDGKDLYVSCTMPSIEIGTIGGG 776  German cockroach
AAA28608 751 VECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGG 830  fruit fly
P16393   825 TVLPPQSACLQMMDVKGSNIHGSGLNASQLARIVCATVMAGELSLMSALAAGHLVKSHMKHNRSALNIASplpsidevat 904  purple sea urchin
P00347   808 TNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQD---------- 877  Chinese hamster
P20715   804 TNLAPQQACLQMLGVQGASTETPGKNACQLAQIVCSTVMAGELSLMAALAAGHLVKSHMVHNRSKINLQD---------- 873  African clawed frog
P54960   777 TVLPPQAACLDMLGVRGANEMCPGENANTLARIVCGTVLAGELSLMSALAAGHLVKSHMRHNRSSVSTSGs--------- 847  German cockroach
AAA28608 831 TGLPGQSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSIAVNSannp------ 904  fruit fly
P16393   905 hrrsksvdfsalkessaaAPGTCTANAS 932  purple sea urchin
P00347   878 ------------------LQGTCTKKSA 887  Chinese hamster
P20715   874 ------------------LPGTCTKKAA 883  African clawed frog
P54960   848 ------------------EPSTPACKS- 856  German cockroach
AAA28608 905 ---------------lnvTVSSCSTIS- 916  fruit fly
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