3NUQ,4G9B,1CQZ,2B0C


Conserved Protein Domain Family
HAD-SF-IA-v3

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TIGR01509: HAD-SF-IA-v3 
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haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
This model represents part of one structural subfamily of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The superfamily is defined by the presence of three short catalytic motifs. The subfamilies are defined based on the location and the observed or predicted fold of a so-called "capping domain", or the absence of such a domain. Subfamily I consists of sequences in which the capping domain is found in between the first and second catalytic motifs. Subfamily II consists of sequences in which the capping domain is found between the second and third motifs. Subfamily III sequences have no capping domain in either of these positions. The Subfamily IA and IB capping domains are predicted by PSI-PRED to consist of an alpha helical bundle. Subfamily I encompasses such a wide region of sequence space (the sequences are highly divergent) that representing it with a single model is impossible, resulting in an overly broad description which allows in many unrelated sequences. Subfamily IA and IB are separated based on an aparrent phylogenetic bifurcation. Subfamily IA is still too broad to model, but cannot be further subdivided into large chunks based on phylogenetic trees. Of the three motifs defining the HAD superfamily, the third has three variant forms: (1) hhhhsDxxx(x)D, (2) hhhhssxxx(x)D and (3) hhhhDDxxx(x)s where _s_ refers to a small amino acid and _h_ to a hydrophobic one. All three of these variants are found in subfamily IA. Individual models were made based on seeds exhibiting only one of the variants each. Variant 3 (this model) is found in the enzymes beta-phosphoglucomutase (TIGR01990) and deoxyglucose-6-phosphatase, while many other enzymes of subfamily IA exhibit this variant as well as variant 1 (TIGR01549). These three variant models were created with the knowledge that there will be overlap among them - this is by design and serves the purpose of eliminating the overlap with models of more distantly related HAD subfamilies caused by an overly broad single model. [Unknown function, Enzymes of unknown specificity]
Statistics
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PSSM-Id: 273662
Aligned: 34 rows
Threshold Bit Score: 104.424
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NUQ_A        61 FFDIDNCLYKSstrihd----lmqqsILRFFQTHLKLS------Pe-------------dAHVLNNSY---Y-K------ 107 Saccharomyces c...
WP_001300440  14 LLDMDGTLLDLafd---------nyfWQKLVPETWGAKn----gV---------------TPQEAMEY---MrQ------ 56  Enterobacteriaceae
WP_010907220  15 ILDLDGTLIDLyfd---------hhfWKTVVPQAYAKK------C---------------NLDLATSRqllK-Q------ 57  Pasteurella mul...
WP_015445566  34 VFDIGKVLIHYdpn----------lpYSRLVPDEAERSwffanvC---------------TSDWNIEQ---D-Rg----- 79  Sinorhizobium m...
WP_010887473  18 AFDWGGVFTVGtfdgrs----tqnvaERSGVPVEKVRE------Syfrh--------irqLEVGAWTL---P-------- 68  Deinococcus rad...
WP_010969839   8 MIDVEGVLVCGrpsd--------grpWASTIEDDLGLS------Vaa------------lQQEFFSPY---W-Ne----- 52  Sinorhizobium m...
NP_001254294  11 VYDFGGVLLSYegvmek----wvamsRSLGLPDDAVHS------EsvgiefsqwlgpdrsLFLGTLTV---D-Dlegglf 76  Caenorhabditis ...
CAA85471       7 AFDLDGVLALPsiaga-----frrseEALALPRDFLLG------Ayqtefp---egpteqLMKGKITF---S-Qwvp-lm 67  house mouse
WP_010874296   8 VFDLDGVLIDSeeanyqafaygieqlGLPRPDRQTVVS------Lv--------------gLKASLML---E-Kl----- 58  Synechocystis s...
1CQZ_A         7 AFDLDGVLALPsiaga-----frrseEALALPRDFLLG------Ayqtefp---egpteqLMKGKITF---S-Qwvp-lm 67  house mouse
3NUQ_A       108 -EygLAIRGLVMFhkvnALE-----Y-----NR-----LVDDSLPLqdI----LK--PDIPLRNMLLRLRQS-GkidkL- 163 Saccharomyces c...
WP_001300440  57 -QyhDVQHTLNWY----CLD-----YwseqlGL-----DICAMTTE--Mgp-rAV--LREDTIPFLEALKAS-G----Kq 111 Enterobacteriaceae
WP_010907220  58 -RydAIEHSKDWY----CLD-----FwaktlDL-----PLRELYQA--Qgp-tLK--VRSDVAPFLQAVRKM-Nk--qM- 113 Pasteurella mul...
WP_015445566  80 -RswEEAEAILIR----NHP-----E-----REdhiraFRRHWHEM--V----PH--AYVETVAIMGGLIAD-G----Wd 131 Sinorhizobium m...
WP_010887473  69 -QfwETVQQETGM----TLP-----Y-----AD-----F-EALYLG--S----IH--DNAPMYTTLAALPRSvR----V- 114 Deinococcus rad...
WP_010969839  53 -IvlGRAAPVDHL----KPVlakiaP-----HL-----PYDDFIAY--WfendAR--LNIKLLEELRQQRKA-Gk--rV- 109 Sinorhizobium m...
NP_001254294  77 lQylKHK---YGN----KLTdnvviK-----P------FTECLRGE--N----VK--IHKNMQKTVEILHKK-Gf--kT- 126 Caenorhabditis ...
CAA85471      68 dEsyRKSSKTCGA----NLPenfsiS-----QI-----FSQAMAAR--------S--INRPMLQAAIALKKK-Gf--tT- 119 house mouse
WP_010874296  59 -GcpRQEVER-------IFKd----------FV-----QPFYIENL--Pq--lAA--PMPNAVTVLTTLKQR-Dy--rI- 105 Synechocystis s...
1CQZ_A        68 dEsyRKSSKACGA----NLP-----E-----NF-----SISQIFSQ--Am---AArsINRPMLQAAIALKKK-Gf--tT- 119 house mouse
3NUQ_A       164 -WLFTNAY------KnhaircLRL------LGI-----ADLFDGLTYcdysrtD--TLVCKPHVKAFEKAMKESGLArYE 223 Saccharomyces c...
WP_001300440 112 rILLTNAH------P------HNLsvklehTGL-----DAHLDLLLS------ThtFGYPKEDQRLWHAVAEATGLK-AE 167 Enterobacteriaceae
WP_010907220 114 -ILLTDSN------P------FSLalklqyCDF-----VATFDLLLSs----hH--FGAPKIEQPLWHNLQQKHYFN-PA 168 Pasteurella mul...
WP_015445566 132 vTMLTNFAsdtfreA------QKL------YPF-----LTLPRGVTVs----gD--VRLIKPDLAIYRTHAEAFDLD-PG 187 Sinorhizobium m...
WP_010887473 115 -GLLSNNY------P------VVS------EHLgrdprFARFDALVFs----nE--IGHKKPAPEAFAALEQKMGLP-AA 168 Deinococcus rad...
WP_010969839 110 -YLATDQE------Hvra-ahLVEa-----LGL-----GSHCDGIYYs----aA--LGSRKPDQAFFKQVAALSGLR-PD 164 Sinorhizobium m...
NP_001254294 127 -AMLTNNM------Fldk-ehKETrl---pCDL-----T-HFDEVVEs----cL--EHLMKPDARFYHLVEKRLGVK-PE 182 Caenorhabditis ...
CAA85471     120 -CIVTNNW------Lddg-dkRDSlaq-mmCEL-----SQHFDFLIEs----cQ--VGMIKPEPQIYNFLLDTLKAK-PN 178 house mouse
WP_010874296 106 -LACTSGD------Rrt---qTAAlq---gVGL-----WSAIETMLAad------dsPFAKPDPRYLQQLLAPYDYQt-- 159 Synechocystis s...
1CQZ_A       120 -CIVTNNWldd-gdKrd---sLAQm----mCEL-----SQHFDFLIEs----cQ--VGMIKPEPQIYNFLLDTLKAK-PN 178 house mouse
3NUQ_A       224 NAYFIDDSGKNIETGIKLGM-KTCIH 248 Saccharomyces cerevisiae S288c
WP_001300440 168 RTLFIDDSEAILDAAAQFGI-RYCLg 192 Enterobacteriaceae
WP_010907220 169 RTLFIDDTENVLDSAKQFGIaYTVGV 194 Pasteurella multocida
WP_015445566 188 ATLFIDDSAANVEGARAAGW-HAVqf 212 Sinorhizobium meliloti
WP_010887473 169 QVAFVDDVQENIDAAGAFGF-HGILY 193 Deinococcus radiodurans
WP_010969839 165 QLLLVDDPPANIDAARLCGW-NAIHW 189 Sinorhizobium meliloti
NP_001254294 183 EIVFLDDLHENIEAAEKLGW-NTILV 207 Caenorhabditis elegans
CAA85471     179 EVVFLDDFGSNLKPARDMGM-VTILV 203 house mouse
WP_010874296 160 -LLHVEDAEVGIRMGQACGA-VSIFA 183 Synechocystis sp. PCC 6803
1CQZ_A       179 EVVFLDDFGSNLKPARDMGM-VTILV 203 house mouse
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