2YTR,1A1F,1A1H,1A1I,1AAY,1JK1,1MEY,1P47,1UN6,1P7A,1X6E,2COT,2DMD,2EL4,2EL5,2ELZ,2EM1,2EM2,2EM3,2EM4,2EM5,2EM6,2EM9,2EMA,2EMC,2EME,2EMF,2EMG,2EMH,2EMI,2EMJ,2EMK,2EML,2EMM,2EMP,2EMV,2EMW,2EMX,2EMY,2EMZ,2EN0,2EN1,2EN4,2EN6,2EN7,2EN8,2EN9,2ENA,2ENE,2ENF,2ENH,2EOE,2EOF,2EOG,2EOI,2EOJ,2EOK,2EOL,2EOM,2EOO,2EOP,2EOR,2EOU,2EOW,2EOX,2EOY,2EOZ,2EP0,2EP1,2EP2,2EP3,2EPT,2EPU,2EPV,2EPW,2EPY,2EQ0,2EQ1,2EQ2,2EQ3,2EQW,2M0F,2YRH,2YRJ,2YSV,2YTA,2YTB,2YTD,2YTF,2YTG,2YTH,2YTI,2YTJ,2YTK,2YTM,2YTN,2YTP,2YTQ,2YTS,2YTT,2YU8


Conserved Protein Domain Family
ZF_C2H2
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sd00018: ZF_C2H2 
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Zinc finger, C2H2 type
The C2H2 zinc finger is a classical zinc finger domain. C2H2-type zinc fingers are ubiquitous; more than 1% of all mammalian proteins are predicted to contain at least one zinc finger. They often function as DNA or protein binding structural motifs, such as in eukaryotic transcription factors, and therefore they play important roles in cellular processes such as development, differentiation, and oncosuppression. C2H2 zinc finger proteins contain from 1 to more than 30 zinc finger repeats.
Links
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Statistics
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PSSM-Id: 275369
Aligned: 328 rows
Threshold Bit Score: 27.6587
Created: 21-Dec-2011
Updated: 22-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputativeC2H2 Zn finger
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:1MEY: Mouse zinc finger contacts to Zn ion.
    - View structure with Cn3D
  • Comment:The small C2H2 zinc finger domain is conformationally stabilized by coordinating a zinc ion on the two invariant cysteine and histidine residues.
  • Citation:PMID 2028256
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #    #            #     # 
2YTR_A         13 YKCN--ECGKAFSQTSKLARHQr--IHT 36   human
1MEY_C          5 YKCP--ECGKSFSQSSNLQKHQr--THT 28   green anole
BAE06785      324 HFCD--FEGCEKAYTKSSHLKAhrrTHT 349  Ciona intestinalis
AAI08432      268 HICH--LPGCGKVYGKTSHLKAhlrWHA 293  African clawed frog
NP_001100818   66 YNCP--LCEKVCTTQHQLTMHIr--QHN 89  
XP_973372      78 YVCP--ICDTMLTSQHEFTLHIr--SHN 101 
XP_002826832  388 HPCP--SCCLAFSSQKFLSQHVe-rNHS 412  Sumatran orangutan
EFZ22402      357 HSCP--HCSMAFSNGGQLTGHIr--IHT 380  red fire ant
XP_001603756   66 HPCP--ACPTVLSSSRELTHHLr--GHN 89  
EHB06023      276 HACPaeGCDRSDELTRHLRIHT---GHK 300  naked mole-rat

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