1W7P


Conserved Protein Domain Family
zf-RanBP2

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sd00029: zf-RanBP2 
Click on image for an interactive view with Cn3D
RanBP2-type zinc finger
The zf-RanBP2 domain represents a new superfamily of C2C2-type zinc finger motif, which is characterized by the conserved sequence pattern W-X-C-X(2,4)-C-X(3)-N-X(6)-C-X(2)-C. They fold into a structure composed of two orthogonal beta-hairpin strands that sandwich a single Zn2+ ion coordinated with four cysteine residues. zf-RanBP2 domains are mainly found in eukaryotic proteins and some exist in bacteria and archaea. According to different binding partners, the superfamily can be classified into several families. For instance, the E3 SUMO-protein ligase RanBP2-like family binds Ran, the nuclear protein localization protein 4 homolog (NPL4)-like family binds ubiquitin, and the zinc finger Ran-binding domain-containing protein 2 (ZRANB2)-like family binds single-stranded RNA (ssRNA). Most of superfamily members contain one copy of zf-RanBP2, but some contain several zf-RanBP2 domains.
Statistics
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PSSM-Id: 275376
Aligned: 1088 rows
Threshold Bit Score: 28.504
Created: 4-Apr-2014
Updated: 22-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C C CClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #                   #  #                                                   
1W7P_D        118 WVCPiCMvsNETqgeftkdtlptpICINCgvpadyeltkssincsn---------------------------------- 163  baker's yeast
EMP40614     1510 WQCNvCSvkNSLtt---------sQCSACqapiqntsssvkgpdgkssftvtsatstp---------------------- 1558 green seaturtle
XP_002937704 1348 WQCDcCLakNAPts---------tSCVCCqtpnknqssltsstcisapsft----------------------------- 1389 western clawe...
XP_003762019  292 WRCLsCSqhNSTgs---------sXCPDCgadkagdcccgrapsa----------------------------------- 327  Tasmanian devil
EFX89537       10 WKCViCLqvNPTek---------sCCFNCgakrsctiekeevrpmcspvnfee--------------------------- 53   common water ...
XP_001844902  105 WRCLvCNatNPDn----------rNCSECgtfkvlat------------------------------------------- 131  southern hous...
CBH15622      134 WMCAaCEknNRIddld-----dnsCCGFCgydmapmtmteaealriqqerserlretqerfdalsakdadeqfgdemaga 208  Trypanosoma b...
CCC51527      129 WMCIaCEknNRIddld-----dnsRCGFCgydmapmtmtesealriqherserlreaqeqfdslsardadeqfgdetaga 203  Trypanosoma v...
CCC93725      131 WMCIaCEknNRVddld-----dnsRCGFCgydmapmtmtesealriqqerserlreeqekfdelsakdadeqfgdetaga 205  Trypanosoma c...
CCC93723      260 WLCGgCGnlCQQst--------hsSCPTCgspkv---------------------------------------------- 285  Trypanosoma c...
Feature 1                                                                                         
1W7P_D        164 ------------------------------------------------------------------------aidpnanp 171  baker's yeast
EMP40614     1559 -------------------------------------------------------------isfsfgreipstcttsgfg 1577 green seaturtle
XP_002937704 1390 -------------------------------------------------------------------fgkesatnklgfg 1402 western clawe...
XP_003762019  328 -------------------------------------------------------------------------rkaarlf 334  Tasmanian devil
EFX89537       54 -----------------------------------------------------------------nnrssknhsqlkhsv 68   common water ...
XP_001844902      --------------------------------------------------------------------------------      southern hous...
CBH15622      209 selpaalkqgvppaprtmfdipevkpfaptpqgtkhsrilrkphpasspgapsgppgfdwmcrepscavinsgdeecctg 288  Trypanosoma b...
CCC51527      204 snlpkelqqpipvvqrpalnipevkpfspmplesshsrilkkprpssllhttngppgfdwmcrqptcgainsgdeencsg 283  Trypanosoma v...
CCC93725      206 dglsppvkqtlpppprgvv-nipevkpftplpqetkhsrilrsrpspspsvpagppgfdwmcreprcavinagdeencta 284  Trypanosoma c...
CCC93723          --------------------------------------------------------------------------------      Trypanosoma c...
Feature 1                                      
1W7P_D        172 qnqfgvnseNICPaCTfaNHPqignCEIC 200  baker's yeast
EMP40614     1578 eqfmlkedqWACNvCLvqNEAtdknCSAC 1606 green seaturtle
XP_002937704 1403 qqllknkeqWTCSkCLqkNDAlvslCSYC 1431 western clawed frog
XP_003762019  335 paqplpppeWACPaCTllNEAktknCAAC 363  Tasmanian devil
EFX89537       69 sysssssakWTCPhCLflNVAsaqdCMTC 97   common water flea
XP_001844902  132 -sksklknsWACSeCDtiNFWdvatCAEC 159  southern house mosquito
CBH15622      289 cgkhiepteWECChCGavNHMtrarCFNC 317  Trypanosoma brucei gambiense DAL972
CCC51527      284 cgariepseWECChCGamNHMsrakCFNC 312  Trypanosoma vivax Y486
CCC93725      285 cgthiepkdWECChCGamNHMsrakCFNC 313  Trypanosoma congolense IL3000
CCC93723      286 -----slseIVCPhCSvpNHCsrksCFRC 309  Trypanosoma congolense IL3000

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