2V9S,3J0A,3J0A,3J0A,3J0A,3J0A,3J0A,3J0A,3J0A,3RIZ,3RIZ,3RIZ,3RIZ,3RIZ,1A9N,1A9N,1DFJ,1DS9,1DS9,1FQV,1G9U,1H6U,1K5D,1KOH,1LTX,1OGQ,1OOK,1OZN,1PGV,1W8A,1WWL,1XCD,1XEU,1XEU,1XKU,1XKU,1XWD,2ELL,2FT3,2FT3,2ID5,2ID5,2ID5,2IFG,2JE0,2JQD,2O6Q,2O6R,2O6S,2OMZ,2OMZ,2OMZ,2OMZ,2OMZ,2OMZ,2OMZ,2OMZ,2R9U,2UZX,2UZX,2V70,2WFH,2WQX,2XOT,2XOT,2XOT,2Z63,2Z63,2Z7X,2Z7X,2Z7X,2Z7X,2Z7X,2Z7X,3A79,3A79,3A79,3A79,3A79,3A79,3B2D,3B2D,3B2D,3B2D,3B2D,3BZ5,3C6P,3CIG,3CIG,3CIG,3CIG,3CIG,3CIG,3CIG,3CIG,3CIG,3CVR,3E6J,3FXI,3G04,3G04,3G06,3G3A,3M18,3OGK,3OJA,3OJA,3OJA,3OJA,3OJA,3OJA,3OJA,3REZ,3RFJ,3RFJ,3RFJ,3RFJ,3RG1,3RG1,3RG1,3RG1,3T6Q,3T6Q,3T6Q,3T6Q,3T6Q,3TWI,3UL8,3UL9,3ULU,3ULU,3ULU,3ULU,3ULU,3ULU,3ULU,3ULU,3ULU,3V44,3V44,3V44,3V44,3VQ1,3VQ1,3VQ1,3W3G,3W3G,3W3G,3W3G,3W3G,3W3G,3W3G,3ZYI,3ZYJ,3ZYJ,3ZYN,3ZYO,3ZYO,3ZYO,4AW4,4AY9,4B8C,4CC4,4ECN,4ECO,4ECO,4ECO,4EZG,4FCG,4FCG,4FHO,4FHO,4FHO,4FHO,4FMZ,4FMZ,4FMZ,4FMZ,4G8A,4G8A,4G8A,4G8A,4GLP,4GT6


Conserved Protein Domain Family
LRR_1
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sd00031: LRR_1 
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leucine-rich repeats
A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.
Links
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Statistics
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PSSM-Id: 275378
Aligned: 1148 rows
Threshold Bit Score: 29.7776
Created: 22-Oct-2014
Updated: 22-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:leucine-rich repeat [structural motif]
Evidence:
  • None
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     ###############                 ###                                             
2V9S_A     34 ITEIRLEQNTIKVIPpga-----------fspYKKLRRIDLSNNq--ISELAPdaf----qgLRSLNSLVLYGNk----I 92  human
1PGV_A     43 LKEVNINNMKRVSKErirsli------eaacnSKHIEKFSLANTa--ISDSEArglielietSPSLRVLNVESNf----L 110 Caenorhabditis ele...
2Z63_A    306 WQHLELVNCKFGQFPtl--------------kLKSLKRLTFTSNk-gGNAFSEv-------dLPSLEFLDLSRNg----L 359
2Z7X_B    304 IKNFTVSGTRMVHMLcp-------------skISPFLHLDFSNNlltDTVFENcg------hLTELETLILQMNq----L 360 human
3C6P_B    399 MTRFRLCIIEPKAPDyltlepldigfgaivehCKDLRRLSLSGL---LTDKVFeyi---gtyAKKMEMLSVAFAg----D 468 thale cress
3G04_C     57 ISRIYVSIDVTLQQLeshs----------fynLSKVTHIEIRNTr-nLTYIDPdal----keLPLLKFLGIFNTg----L 117 human
3G04_C     15 DFRVTCKDIQRIPSL-----------------PPSTQTLKLIETh--LRTIPShaf----snLPNISRIYVSIDv---tL 68  human
3OGK_B    114 LKSVHFRRMIVSDLDldrl---------akarADDLETLKLDKCs--GFTTDGllsi--vthCRKIKTLLMEESsfsekD 180 thale cress
4G8A_A    399 LKYLDLSFNGVITMSsnf------------lgLEQLEHLDFQHSn--LKQMSEfsv---flsLRNLIYLDISHThtrvaF 461 human
4GT6_A    267 LASVKXPDSVVSIGTgaf------------xnCPALQDIEFSSR---ITELPEsvf----agCISLKSIDIPEG-----I 322 Faecalibacterium p...

Feature 1                                                                   
2V9S_A     93 TELPksl----fegLFSLQLLLLNANKINXLrvd-------afqDLHNLNLLSLYDNKLQTI 143 human
1PGV_A    111 TPELlarllrstlvTQSIVEFKADNQRQSVLgnqvemdmmmaieENESLLRVGISFASMEAR 172 Caenorhabditis elegans
2Z63_A    360 SFKGccsq--sdfgTTSLKYLDLSFNGVITMssn--------flGLEQLEHLDFQHSNLKQM 411
2Z7X_B    361 KELSkiae--mttqMKSLQQLDISQNSVSYDekkg------dcsWTKSLLSLNMSSNILTDT 414 human
3C6P_B    469 SDLGmhhv---lsgCDSLRKLEIRDCPFGDKalla------nasKLETMRSLWMSSCSVSFG 521 thale cress
3G04_C    118 KMFPdltk---vysTDIFFILEITDNPYMTSipvn-----afqgLCNETLTLKLYNNGFTSV 171 human
3G04_C     69 QQLEshs----fynLSKVTHIEIRNTRNLTYidpd------alkELPLLKFLGIFNTGLKMF 120 human
3OGK_B    181 GKWLhel----aqhNTSLEVLNFYMTEFAKIspkdl---etiarNCRSLVSVKVGDFEILEL 235 thale cress
4G8A_A    462 NGIFn--------gLSSLEVLKMAGNSFQENflpd------iftELRNLTFLDLSQCQLEQL 509 human
4GT6_A    323 TQILdda----fagCEQLERIAIPSSVTKIPesa--------fsNCTALNNIEYSGSRSQWN 372 Faecalibacterium prausnitzii A2-165

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