2FT3,1XKU,3ULU,2BNH,3TSR,1A4Y


Conserved Protein Domain Family
LRR_RI

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sd00033: LRR_RI 
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leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily
A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.
Statistics
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PSSM-Id: 275380
View PSSM: sd00033
Aligned: 303 rows
Threshold Bit Score: 62.1721
Threshold Setting Gi: 133146
Created: 9-Jul-2014
Updated: 22-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:leucine-rich repeat [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      ############     ########      #                                                
2FT3_A      35 LRVVQCSDLGLK-----AVPKEISP------DTTLLDLQNNDISe----LRKDDFKGLq-------HLYALVLVNNKIs- 91   cattle
1A4Y_A       4 IQSLDIQCEELSd----ARWAELLPll---qQCQVVRLDDCGLTe---aRCKDISSALrv----npALAELNLRSNELgd 69   human
ELR56835    29 YEVVRLDDCGLTevrckDIGSALQAn----aSLTELSLRTNELGd---gGVLLVLQGLqsp---tcKIQKLSLQNCCLte 98   Bos grunniens mutus
1172922     29 SLKLNTAEDAKD-----VIKEIEDFd-----SLEALRLEGNTVGveaarVIAKALEKKse----lkRCHWSDMFTGRLr- 93   human
3914621     29 TLKLNTAQDAEE-----VIREIEEYe-----GLQALRLEGNTVGv----EAAKAIAEVlqrkpdlkRCHWSDMFTGRLr- 93   African clawed frog
EFA00171    29 SLKLDTVDDAKS-----VIEEIEKCt-----NLQFLNLEGNTLGv---eASKGIAKALekhp-efkRALWKDMFTGRMk- 93   red flour beetle
CAG32161    25 FKGQSLKLNTAEda--eEVIKQIEEf----dGLEALRLEGNTVGveaakVIAKALEKKse----lkRCHWSDMFTGRLr- 93   chicken
AAI24541    26 KGKGLKLDNAQSve--qMVKEIGEFe-----GLRALRLEGNTIGveaaqTIAKALENKsd----lqCCHWSDMFTGRLr- 93   zebrafish
Q9NX02     728 CHLQRVVFKNISp---aDAHRNLCLalrghkTVTYLTLQGNDQDd----MFPALCEVLrhp---ecNLRYLGLVSCSAt- 796  human
Q96MN2     614 DEHSSTSDYSLIcw--hHICSVLTTs----gHLRELQVQDSTLSe---sTFVTWCNQLrhp---scRLQKLGINNVSFs- 680  human
Feature 1                                                                                      
2FT3_A      92 ---kIHEKAFSPLr--------KLQKLYISKNHL----VEIPPnl-------psSLVELRIHDNRIRkv----pkGVFSG 145  cattle
1A4Y_A      70 ---vGVHCVLQGLqtp----scKIQKLSLQNCCLtg-aGCGVLsstl---rtlpTLQELHLSDNLLGda----glQLLCE 134  human
ELR56835    99 agcgALPGVLRSLp--------TLRELHLSDNPLg--dAGLRLlcegl-ldpqcRLEKLQLEYCSLTaa----scEPLAA 163  Bos grunniens mutus
1172922     94 ---tEIPPALISLgeglitagaQLVELDLSDNAFg--pDGVQGfeallkssacfTLQELKLNNCGMGigggkilaAALTE 168  human
3914621     94 ---pEIPTALRSLgdalitagaQLTELDLSDNAFg--pDGVRGfeallksptcfTLQELKLNNCGMGigggkilaAALTE 168  African clawed frog
EFA00171    94 ---tEIPKALEFLgsglvtagaRLTELDMSDNAFg--pIGVEGlaallrssscyALEELRLNNNGLGitggkllaSALTD 168  red flour beetle
CAG32161    94 ---sEIPPALISLgdalitagaQLVELDLSDNAFg--pDGVRGfeallkspacyTLQELKLNNCGMGigggkilaAALKE 168  chicken
AAI24541    94 ---aEIPPALVSLgdalilagaRLKVLDLSDNAFg--pDGVKGiekllksaachTLQELRLNNCGMGigggkilaAALSE 168  zebrafish
Q9NX02     797 ----TQQWADLSLale---vnqSLTCVNLSDNELldegAKLLYttlr---hpkcFLQRLSLENCHLTea----ncKDLAA 862  human
Q96MN2     681 ---gQSVLLFEVLfy-----qpDLKYLSFTLTKLs--rDDIRSlcdal-nypagNVKELALVNCHLSpi----dcEVLAG 745  human
Feature 1                                                                                      
2FT3_A     146 l----------rNMNCIEMGGNPLen--sgFEPGAFDGL-----KLNYLRISEAKLTg--------IPKDLp---eTLNE 197  cattle
1A4Y_A     135 glld-----pqcRLEKLQLEYCSLsa---aSCEPLASVLra-kpDFKELTVSNNDINeag---vrvLCQGLkdspcQLEA 202  human
ELR56835   164 vlr------atrDLKELVVSNNDIge---aGVQALCRGLaesacQLETLKLENCGLTaanckdlcgIVASQa----SLKD 230  Bos grunniens mutus
1172922    169 chrkssaqgkplALKVFVAGRNRLendgatALAEAFRVIg----TLEEVHMPQNGINhpgitalaqAFAVNp----LLRV 240  human
3914621    169 chkkssahgkplALKVFIAGRNRLendgatALSEAFRLIg----TLEEVHMPQNGINhagitalaeSFKANs----LLKV 240  African clawed frog
EFA00171   169 cynssketgkplQLKVFIAGRNRLenegakALAEVFKMIg----TLEEIAMPQNGIYhvgisalseAFTQNk----NLQI 240  red flour beetle
CAG32161   169 chrkssaqgkplALKIFMAGRNRLendgatALAEAFGIIg----TLEEVHMPQNGINhpgitalaqAFAINs----LLKV 240  chicken
AAI24541   169 chqqssalgapfKLKVFIAGRNRLendgatALAQAFQLMg----SLEEVHMPQNGINypg----vtALATAmqhnpQLRV 240  zebrafish
Q9NX02     863 vlv------vsrELTHLCLAKNPIgn---tGVKFLCEGLrypecKLQTLVLWNCDITsdg----ccDLTKLlqeksSLLC 929  human
Q96MN2     746 llt------nnkKLTYLNVSCNQLdtg-vpLLCEALCSPd---tVLVYLMLAFCHLSeqc----ceYISEMllrnkSVRY 811  human
Feature 1                                                                                      
2FT3_A     198 LHLDHNKIQa----iELEDLLRYs----KLYRLGLGHNQIRm-----IENGSLSFLp-----TLRELHLDNNKLs----- 254  cattle
1A4Y_A     203 LKLESCGVTs----dNCRDLCGIvaskaSLRELALGSNKLGd----vGMAELCPGLlhp-ssRLRTLWIWECGIta---- 269  human
ELR56835   231 LDLGSNRLGda---gLAELCPGLlspssQLRTLWLWECDLTv----sGCRDLCRVLqa--keALKELSLAGNSLgd---e 298  Bos grunniens mutus
1172922    241 INLNDNTFTekgavaMAETLKTLr----QVEVINFGDCLVRskgavaIADAIRGGLp-----KLKELNLSFCEIkrdaal 311  human
3914621    241 INLNDNTFTekggvaMAEALKTLr----QVEVINFGDCLVRskgaqaIASALKEGLh-----KLKDLNLSYCEI------ 305  African clawed frog
EFA00171   241 LNLNDNTIGekgaeaIAKALPHLq----QLKEINFGDCLLKt-----AGAISLANVlktghaNLEELTLGHNEIr----- 306  red flour beetle
CAG32161   241 INLNDNTFTekgavaMAETLKALr----QVEVINFGDCLVRskgalaIADALKEGLh-----KLKELNLSFCEIkrdaal 311  chicken
AAI24541   241 LNLNDNTFTkkgamaMAQALKHLr----NVQVINFGDCLVRsegasaLAETVREGLp-----ILKELNLSFGEIm----- 306  zebrafish
Q9NX02     930 LDLGLNHIGvkgmkfLCEALRKPl---cNLRCLWLWGCSIPp----fSCEDLCSALsc--nqSLVTLDLGQNPLgs---s 997  human
Q96MN2     812 LDLSANVLKde---gLKTLCEALkhpdcCLDSLCLVKCFITaagcedLASALISNQ------NLKILQIGCNEIgdvgvq 882  human
Feature 1               
2FT3_A     255 rVPAGLPDL 263  cattle
1A4Y_A     270 kGCGDLCRV 278  human
ELR56835   299 gAQLLCESL 307  Bos grunniens mutus
1172922    312 aVAEAMADK 320  human
3914621    306 -KADAAVSL 313  African clawed frog
EFA00171   307 -LKGGLQLV 314  red flour beetle
CAG32161   312 sVAEAIEDK 320  chicken
AAI24541   307 -EEAALEVA 314  zebrafish
Q9NX02     998 gVKMLFETL 1006 human
Q96MN2     883 lLCRALTHT 891  human

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