Conserved Protein Domain Family

cd00821: PH 
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Pleckstrin homology (PH) domain
PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
PSSM-Id: 275388
View PSSM: cd00821
Aligned: 190 rows
Threshold Bit Score: 28.2774
Threshold Setting Gi: 328877365
Created: 4-Feb-2003
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1PMS_A      34 MEGTLtrvg--------------------akhERHIFLFd---------gLMICCKsnhgqprlpg------assaeyrl 78   house mouse
Q6IFT4      88 IDGPVelkr--------------------glqRQERHLFl---------fNDLFVSakikyn-------------nnfki 125  house mouse
4DIX_A     116 VDFNVvvtqmsg-------------edhtsesIHLFHVGk---------mRIKLCKgkt--------------------v 153  thale cress
3PG7_A     158 KVFHNalkla------------------hkdtKVSIKVGs---------tAVQVTSaertvlg------------qsvfl 198  human
NP_741737  253 YNGDLkslgllrlqtecdvftynrkkkaklsrAQKRFIFf---------fDGAVMFckkrvsnpgttlnsepeyfehkfc 323  Caenorhabditis e...
EFO20727   270 FVGDLcqmgalrlqnecd-iyafkkrtrrlnkAQRRHLFl---------fDGGLLFckkrsqsvpya----seyyehkls 335  Loa loa
Q7TSI1     510 PAPAPapapapapapapg--vtqdhknfcvvhRRQMGLSn---------pFRGLMKlgtv------------------ar 560  house mouse
2KIG_A      24 IAVQGvlckg------------------dsrqSRLLGLVryrlendaqehALFLYThrrmait-----------gddvsl 74   house mouse
3VOQ_A      16 KSFKVsmihr-----------------lrfttDVQLGISg---------dKVEIDPvtnqkast---------kfwikqk 60   human
2OQB_A       8 SVFPGarlltigdan-------geiqrhaeqqALRLEVRagp-----daaGIALYShed-------------------vc 56   Norway rat
1PMS_A      79 kEKFFMrk--vQINDKddts-----eykhAFEIIlkd-----------------gnSVIFSAksa-----------eeKN 123  house mouse
Q6IFT4     126 kNKIRLtdmwtASCVEevgegn--mnaqkSFVLGwp------------------tvNFVATFssp-----------eqKD 174  house mouse
4DIX_A     154 iAKEYYss-amQLCGVrgggn----aaaqALYWQakk-----------------gvSFVIAFese-----------reRN 200  thale cress
3PG7_A     199 nDIYYAse-ieEICLVde----------nQFTLTian----------------qgtPLTFMHq--------------eCE 237  human
NP_741737  324 iPIISLgydtsSRTGAs------------RFEVWdd------------------akTDAYVIetid---------qtaRT 364  Caenorhabditis e...
EFO20727   336 iPTCSLgfsetSKTSSv------------RFEVWdet----------------kseAYVVQPide-----------saRI 376  Loa loa
Q7TSI1     561 rGAMGIwk-efFCELSple--------frLYLSDeertcvescsllrceavgpahsDGRFELvfsgkklalrassqdeAE 631  house mouse
2KIG_A      75 dQIVPLsk-dfMLEEVspdgelyilgsdvTVQLNta------------------elKLVFQLpfg-----------shTR 124  house mouse
3VOQ_A      61 pISIDSdl-lcACDLAeeks-----pshaIFKLTylsn--------------hdykHLYFESda------------atVN 108  human
2OQB_A      57 vFKCSVsr-etECSRVgr----------qSFIITlg------------------cnSVLIQFatp-----------hdFC 96   Norway rat
1PMS_A     124 NWMAAL 129  house mouse
Q6IFT4     175 KWLSLL 180  house mouse
4DIX_A     201 AAIMLA 206  thale cress
3PG7_A     238 AIVQSI 243  human
NP_741737  365 KWIQRL 370  Caenorhabditis elegans
EFO20727   377 KWIQRL 382  Loa loa
Q7TSI1     632 DWLDRV 637  house mouse
2KIG_A     125 TFLQEV 130  house mouse
3VOQ_A     109 EIVLKV 114  human
2OQB_A      97 SFYNIL 102  Norway rat
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