1MI1,1T77


Conserved Protein Domain Family
PH_BEACH

?
cd01201: PH_BEACH 
Click on image for an interactive view with Cn3D
Pleckstrin homology domain in BEACH domain containing proteins
The BEACH domain is present in several eukaroyotic proteins CHS, neurobeachin (Nbea), LRBA (also called BGL, beige-like, or CDC4L), FAN, KIAA1607, and LvsA-LvsF. CHS is a rare, autosomal recessive disorder that can cause severe immunodeficiency and albinism in mammals and beige is the name for the CHS disease in mice. The CHS disease is associated with the presence of giant, perinuclear vesicles (lysosomes, melanosomes, and others) and CHS protein is thought to play an important role in the fusion, fission, or trafficking of these vesicles. All BEACH proteins contain the following domains: PH, BEACH, and WD40. The WD40 domain is involved in mediating protein-protein interactions involved in targeting proteins to subcellular compartments. The combined PH-BEACH motifs may present a single continuous structural unit involved in protein binding. Some members have an additional N-terminal Laminin G-like (LamG) domains Ca++ mediated receptors or an additional C-terminal FYVE zinc-binding domain which targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Statistics
?
PSSM-Id: 275391
Aligned: 100 rows
Threshold Bit Score: 80.3568
Created: 4-Feb-2003
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1MI1_A          1 GPVVLSTPAQLIAP--VVVAKGTLSITTTEIYFEVDeddsafkkid------------------tkvlaytegLHGKWXF 60   Homo sapiens
XP_002899571  192 ERLLMETGCVASRIepLLKFPGCLMLTTLRLYFQPSllnn------------------------------vldPVLNWEY 241  Phytophthora ...
AAN38984      296 ERNILELKCSKISP--LVENPGRLLITNARLYFQPMnni-------------------------------eenRLKNYSL 342  Dictyostelium...
EFW43892      192 ERIVTEVSVDRVTP--LVSNRGRLLLTSSRIYFQPFnnv-------------------------------dpvPVRKYRL 238  Capsaspora ow...
XP_001897877 1920 ERIILSLSAVVVRS--TVESSGEILAGDKRFYFHSDytrsvqk-----------------------rlsrtntLFIRWSY 1974 agent of lymp...
XP_002668942 3053 TIILEPKKCKRITP--LRITEGDLILGEDGVYFIAScsypltirtnss--------------stnhskqlemkKTYNFSY 3116 Naegleria gru...
XP_003339967 2393 EKVSVKLSVVVVQG--HMVSEGVLLYGQQHFYICENftlsplgdvyctkhclsnisdpfifnmcskdrpsdhyTCHRYSY 2470 gray short-ta...
XP_001638061  131 EKIVMETTAKRITP--LVCNPGRVMLTSSRLYFQPFnna-------------------------------dpcPVVKCKL 177  starlet sea a...
XP_002674927  182 EQTLYETHGTKVTP--LVDTHGCILLTNERIYFQPFnni-------------------------------stkPVKKYNL 228  Naegleria gru...
EFA03520      188 EKVVLETEADKVTP--LVVNPGRLLLSTSRLFFQPYnnv-------------------------------esvPVIKIEL 234  red flour beetle
1MI1_A         61 SEIRAVFSRRYLLQNTALEVFXAN---RTSVXFNFpd----qATVKKVVYSL 105  Homo sapiens
XP_002899571  242 TNIDQVYKRRYLLRQIGLEIYLRN---GDSFFFSFrsr-perDDFYALMVGQ 289  Phytophthora infestans T30-4
AAN38984      343 QSIIRVLQRRHSLREIGLELFFDD---GSSLFLKFnntitrnQVYDLLVKHL 391  Dictyostelium discoideum
EFW43892      239 GSVQRIVKRRYLLRQIGLELFLNN---DTSLFFAFgsqeerdRFHDQLLLQP 287  Capsaspora owczarzaki ATCC 30864
XP_001897877 1975 GDLVEIYKRHHLLKDTALEIFLSD---GQTYLIVFedqakrdQFGLQILSSD 2023 agent of lymphatic filariasis
XP_002668942 3117 EEIREIHNRRYLLKNNALEFFLLN---GKSFFFAFddg-etrDRVLSILSSP 3164 Naegleria gruberi strain NEG-M
XP_003339967 2471 SDIKEIHLMRFLLQEIALEIFFRN---GYSKFLVFhns-ernKAFKGFYSLQ 2518 gray short-tailed opossum
XP_001638061  178 SQISRVVKRRYLLRHVGIEIFSKD---SSQMYLVLnsqsdrdQFYRELLKQP 226  starlet sea anemone
XP_002674927  229 RDINRIVRRRHNLRHIGIEVFMQN---NKSIFLAVknq-terDNIYNIILKQ 276  Naegleria gruberi strain NEG-M
EFA03520      235 NSIKRMVKRRFLLRHIGLEIYCSEsssNPHIYLSFrsqqkrdHLYDNLLNQP 286  red flour beetle
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap