1ELW,1E96,1ELR,1FCH,1FCH,1HH8,1IHG,1KT0,1QZ2,1W3B,1W3B,1W3B,1W3B,1WAO,1XNF,2C0L,2C2L,2DBA,2E2E,2FBN,2FI7,2FO7,2GW1,2GW1,2HO1,2HO1,2IF4,2KCK,2LNI,2PL2,2Q7F,2VQ2,2VYI,2XCB,2XEV,2XPI,2XPI,2XPI,2XPI,2Y4T,2Y4T,2Y4T,3AS4,3AS4,3AS4,3CV0,3FP2,3FP2,3FP2,3FP2,3HYM,3MKR,3NF1,3PE3,3Q15,3Q15,3Q15,3RKV,3SF4,3SF4,3SZ7,3U4T,3ULQ,3UPV,3UQ3,3VTX,3ZGQ,3ZGQ,3ZGQ,4A1S,4A1S,4A1S,4ABN,4EQF,4G1T,4GA0,4GCN,4GCO,4GYO,4HOQ,4HOQ,4HOU,4I17,4I1A,4I2W,4JHR,4JHR


Conserved Protein Domain Family
TPR

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sd00006: TPR 
Click on image for an interactive view with Cn3D
Tetratricopeptide repeat
The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.
Statistics
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PSSM-Id: 276809
View PSSM: sd00006
Aligned: 1105 rows
Threshold Bit Score: 29.9622
Threshold Setting Gi: 74604509
Created: 23-May-2013
Updated: 26-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:putative protein binding surface [polypeptide binding site]
Evidence:
  • Structure:1ELW: Human TPR1 domain of Hop bound with Hsp70 peptide; contacts at 4A.
    View structure with Cn3D
  • Structure:1FCH; Human PEX5 TPR region with bound PTS1 peptide; contacts at 4A.
    View structure with Cn3D
  • Comment:side chains form an amphipathic groove or channel
  • Comment:the size of the groove generated may mediate the number of interacting proteins

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #  ##  ## #                                                                    
1ELW_A       4 VNELKEKGNKALs----------------vGNIDDALQCYSEAIKld--------------------------------- 34   human
2XPI_A      84 EDYLRLWRHDALm----------------qQQYKCAAFVGEKVLDit--------------------------------- 114  fission yeast
P32712      17 LMVFLCVGSYLLs-----------------PKWQAVRAEYQRQRDp---------------------------------- 45   Escherichia coli
Q03560     712 YDVWLNIAHVCMe----------------rEQWMAAVQMYSSAMKkfr-------------------------------k 744  nematode
Q9FNS4     123 CRTSRIRARQTLdln------------erkSLYKAAEDGLRRCLAld--------------------------------- 157  Chlamydomonas re...
O42668     244 TVVDTYIGLYYYdlafqnv-----nndsfvQNYGKALQHIQRAFKtr--------------------------------- 285  Schizosaccharomy...
Q13042       3 LERLRKRVRQYLd----------------qQQYQSALFWADKVASls--------------------------------- 33   pygmy chimpanzee
Q4QR29     681 SDVWLNLAHIYVe----------------qKQYISAVQMYENCLRkfy-------------------------------k 713  African clawed frog
A0AVF1      57 EDTNLWIGYCAFh----------------lGDYKRALEEYENATKee--------------------------------- 87   human
Q7PYA1      48 AKTVLQCSKDYDevpeqlkhmwtgfcdfhvGEYKRALQLYEKIYAadgslkdvalnicvcmfylgmydeaqklveelpqs 127  Anopheles gambia...
Feature 1          #  ##  ## ##                                                    #  ##  ##  #
1ELW_A      35 phNHVLYSNRSAAYAKk---------------------------GDYQKAYEDGCKTVDLkp---dwGKGYSRKAAALEF 84   human
2XPI_A     115 -gNPNDAFWLAQVYCCt---------------------------GDYARAKCLLTKEDLYnr----sSACRYLAAFCLVK 162  fission yeast
P32712      46 -lHQFASQQTPEAQLQalqd---------------------kirANPQNSEQWALLGEYYl-----wQNDYSNSLLAYRQ 98   Escherichia coli
Q03560     745 enDSTLQHYLAKAYYRa---------------------------NMLNEAKEALECAMLDql---dnTQLKFNYAIVLKK 794  nematode
Q9FNS4     158 paDPRAYVVLGKTLVQq---------------------------KRYDEARQLYQDGCANtgn--vnPYIWSAWGWLEAR 208  Chlamydomonas re...
O42668     286 nnDPVASSILERYVYSk---------------------------KNYEGCIKLAENVIQNsfsssliADGYYWMGRAYHQ 338  Schizosaccharomy...
Q13042      34 reEPQDIYWLAQCLYLt---------------------------AQYHRAAHALRSRKLDkl----yEACRYLAARCHYA 82   pygmy chimpanzee
Q4QR29     714 hqNTEVLLYLARALFKc---------------------------GKLQECKQILLKARHVap---ndTVLMFNVALVLQR 763  African clawed frog
A0AVF1      88 ncNSEVWVNLACTYFFl---------------------------GMYKQAEAAGFKASKSrl----qNRLLFHLAHKFND 136  human
Q7PYA1     128 plKIRLLFHLAHKLSDedrlmelhgslrdvvedqlslagmhylrSHYQEAIDIYKRVLLDnk---dlLALNVYVAICYYK 204  Anopheles gambia...
Feature 1                       
1ELW_A      85 l-NRFEEAKRTYEEGLK 100  human
2XPI_A     163 l-YDWQGALNLLGETNP 178  fission yeast
P32712      99 a-LQLRGENAELYAALA 114  Escherichia coli
Q03560     795 saKEVLRGHKMTSEQVT 811  nematode
Q9FNS4     209 t-GNVERARKLYDAAVV 224  Chlamydomonas reinhardtii
O42668     339 m-GNNEKAMASYQKAKA 354  Schizosaccharomyces pombe 972h-
Q13042      83 a-KEHQQALDVLDMEEP 98   pygmy chimpanzee
Q4QR29     764 laTLVLKDEKSNLKAVL 780  African clawed frog
A0AVF1     137 e-KKLMSFHQNLQDVTE 152  human
Q7PYA1     205 l-DYYDISQEVLDLYLN 220  Anopheles gambiae str. PEST

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