1BG2,4ATX,3J8X,4LNU,4HNA,1GOJ,1MKJ,4UXT,2Y5W


Conserved Protein Domain Family
KISc_KHC_KIF5

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cd01369: KISc_KHC_KIF5 
Click on image for an interactive view with Cn3D
Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup. Members of this group have been associated with organelle transport. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. In most kinesins, the motor domain is found at the N-terminus (N-type). N-type kinesins are (+) end-directed motors, i.e. they transport cargo towards the (+) end of the microtubule. Kinesin motor domains hydrolyze ATP at a rate of about 80 per second, and move along the microtubule at a speed of about 6400 Angstroms per second. To achieve that, kinesin head groups work in pairs. Upon replacing ADP with ATP, a kinesin motor domain increases its affinity for microtubule binding and locks in place. Also, the neck linker binds to the motor domain, which repositions the other head domain through the coiled-coil domain close to a second tubulin dimer, about 80 Angstroms along the microtubule. Meanwhile, ATP hydrolysis takes place, and when the second head domain binds to the microtubule, the first domain again replaces ADP with ATP, triggering a conformational change that pulls the first domain forward.
Statistics
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PSSM-Id: 276820
Aligned: 21 rows
Threshold Bit Score: 442.539
Created: 5-Feb-2015
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:interaction site for Mg ADP, ATP hydrolysis drives motor function
  • Structure:1BG2: Human ubiquitous kinesin motor domain with bound Mg-ADP
    View structure with Cn3D
  • Citation:PMID 8606779

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #                                                                     
1BG2_A       6 ECNIKVMCRFRPLNese-vnrGDKYIAKFQGe--dTVVIa-----------SKPYAFDRVFQSSTSQEQVYNDcaKKIVK 71   human
4ATX_C       6 ECNIKVMCRFRPLNese-vnrGDKYVAKFQGe--dTVMIa-----------SKPYAFDRVFQSSTSQEQVYNDcaKKIVK 71   Norway rat
4HNA_K       6 ESNIKVMCRFRPLNese-vnrGDKYIAKFQGe--dTVVIa-----------SKPYAFDRVFQSSTSQEQVYNDaaKKIVK 71   human
1GOJ_A       5 ANSIKVVARFRPQNrve-iesGGQPIVTFQGp--dTCTVdsk-------eaQGSFTFDRVFDMSCKQSDIFDFsiKPTVD 74   Neurospora crassa
1MKJ_A       6 ECNIKVMCRFRPLNese-vnrGDKYIAKFQGe--dTVVIa-----------SKPYAFDRVFQSSTSQEQVYNDcaKKIVK 71   human
Q9US60       1 MTSIKVVCRIRPTNqleqdlgGNNVIYPLNDs---TVHIets-------dySGNFVFDRVFHPSSTQNDIFSYsiESTVD 70   Schizosaccharomy...
NP_850742    1 MSNVTVCARFRPRSske-mrdPSRDGVCARPidaeTFVFqdd------kedEFTFSLDRVFYEDSTQAAVYEFlaLPIMR 73   thale cress
CAD98568    27 GSGVHVYCRVRPPNeaekthgNGLLCVNVRSe--qCIEIsssesksdsetkERTFYLDHIFPMDTNQSYVYKTaaKPIVD 104  Cryptosporidium ...
AAR39436     1 MSSIRVVCRFRPQNkle-laqGGDSIVSIAPen-dSVTIngs-------esNHSFSFDYVFPSNTTQRDVYDHaaKPVIE 71   Dictyostelium di...
EAK97338    55 INNIKVICRFRPENeke--lqKGKSIVEFPNt--qTVTLygk-------dyTTHYSFDRVFSPEASQLDIYQFsiAETVD 123  Candida albicans...
Feature 1                   #  # ####                                                          
1BG2_A      72 DVLEGYNGTIFAYGQTSSGKTHTMEGklhd---pegmGIIPRIVQDIFNYIysm---denLEFHIKVSYFEIYLDKIRDL 145  human
4ATX_C      72 DVLEGYNGTIFAYGQTSSGKNHTMEGklhd---pegmGIIPRIVQDIFNYIysm---denLEFHIKVSYFEIYLDKIRDL 145  Norway rat
4HNA_K      72 DVLEGYNGTIFAYGQTSSGKTHTMEGklhd---pegmGIIPRIVQDIFNYIysm---denLEFHIKVSYFEIYLDKIRDL 145  human
1GOJ_A      75 DILNGYNGTVFAYGQTGAGKSYTMMGtsidd--pdgrGVIPRIVEQIFTSIlss---aanIEYTVRVSYMEIYMERIRDL 149  Neurospora crassa
1MKJ_A      72 DVLEGYNGTIFAYGQTSSGKTHTMEGklhd---pegmGIIPRIVQDIFNYIysm---denLEFHIKVSYFEIYLDKIRDL 145  human
Q9US60      71 DLFLGYNGTVLAYGQTGSGKTYTMMGienn---fekeGMTPRMLRRIFDKIrds---pstTEYEVKVSYMEIYMEKIHDL 144  Schizosaccharomy...
NP_850742   74 DAVNGINGTIITYGQTGAGKTYSMEGpgiqdcdehnkGLLPRVVHGMFEQIsss---ndiARYTVKLSMVEIYMEKVRDL 150  thale cress
CAD98568   105 QLFKGINGTVLAYGQTSSGKTFTMEGiigd---nekmGVIPRMVHDVFETIsna---eehIEFQLKVSICEVYMERIRDL 178  Cryptosporidium ...
AAR39436    72 DIMAGYNGTLFVYGQTGSGKTFSMTGindpngdqelrGIVPRMIETVFEFIkna---denIEFGVKASYIEIYMERIRDL 148  Dictyostelium di...
EAK97338   124 DLINGYNGTVLAYGQTGSGKSYTMLGgpqls-dpnskGIIPRISHEIFERIsaneavsseVEYSVCVSFMEIHMEQIRDL 202  Candida albicans...
Feature 1                                                                                      
1BG2_A     146 LDvs----ktNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENtqteq 221  human
4ATX_C     146 LDvs----ktNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENtqteq 221  Norway rat
4HNA_K     146 LDvs----ktNLSVHEDKNRVPYVKGATERFVSSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENtqteq 221  human
1GOJ_A     150 LApq----ndNLPVHEEKNRGVYVKGLLEIYVSSVQEVYEVMRRGGNARAVAATNMNQESSRSHSIFVITITQKNvetgs 225  Neurospora crassa
1MKJ_A     146 LDvs----ktNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENtqteq 221  human
Q9US60     145 LSek----ndRLTVHEDKLQGVYVQGLKTIYVSSETEALDILNKGMGSRAVASTSMNAQSSRSHSIFVLEVVQTDtesge 220  Schizosaccharomy...
NP_850742  151 LDls----kaNIQIKENKTQGILLSGVTEVPVSDSVEALQHLCTGLANRAVGETQMNMSSSRSHCAYLFTIQQDSvkdkr 226  thale cress
CAD98568   179 LDtsg--tksNLRIHEDKIHGIYVKDLSEYFVTSPEEVFELMALGHKHRAVASTNMNSYSSRSHLIFMLQLQQKNvfdss 256  Cryptosporidium ...
AAR39436   149 LDpr----kdNLKVREEEGKGVWVEGTSEVFFYREEDILDVINTGISNRAIAETRMNAESSRSHSIFILTIQQKNlkvgs 224  Dictyostelium di...
EAK97338   203 IDvvnnefdhKFTIHEDKSNGIYVKGLATRSVTNELELLNILSEGLKYRSISSTQMNEESSRSHTIFQVKLTQKHmetev 282  Candida albicans...
Feature 1               #                                                                      
1BG2_A     222 KLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGs----tYVPYRDSKMTRILQDSLGGNCRTT 297  human
4ATX_C     222 KLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGs----tYVPYRDSKMTRILQDSLGGNCRTT 297  Norway rat
4HNA_K     222 KLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGs----tYVPYRDSKMTRILQDSLGGNARTT 297  human
1GOJ_A     226 AKSGQLFLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGks---sHVPYRDSKLTRILQESLGGNSRTT 302  Neurospora crassa
1MKJ_A     222 KLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGs----tYVPYRDSKMTRILQDSLGGNCRTT 297  human
Q9US60     221 TRRGRLFLVDLAGSESVGKSGAVGQTLEEAKKINRSLSTLGMVINSLTDSkl---sHVPYRDSKLTRILKESLGGNSRTT 297  Schizosaccharomy...
NP_850742  227 VKTGKLILVDLAGSEKADKTGAEGRVLEEAKTINKSLSALGNVINALTSGpsskgnHIPYRDSKLTRILQDALGGNSRMA 306  thale cress
CAD98568   257 IKVGKLFLVDLAGSEKISKTGAEGLTLDEAKTINKSLSCLGNVINALTDNtk---nFIPYRDSKLTRILQNSLGGNSLTA 333  Cryptosporidium ...
AAR39436   225 IKTGKLYLVDLAGSEKISKTGAQGTTLDEAKMINKSLSSLGNVINALTDGks---tHIPYRDSKLTRVLQESLGGNSRTT 301  Dictyostelium di...
EAK97338   283 IKRSNLFLVDLAGSEKVDKTGAQGQTLEEAKKINSSLSALGNVINALTDGks---tHIPYRDSKLTRILQESIGGNSRTS 359  Candida albicans...
Feature 1                                  
1BG2_A     298 IVICCSPSsyNESETKSTLLFGQRAKTI 325  human
4ATX_C     298 IVICCSPSsyNESETKSTLLFGQRAKTI 325  Norway rat
4HNA_K     298 IVICCSPSsyNESETKSTLLFGQRAKTI 325  human
1GOJ_A     303 LIINCSPSsyNDAETLSTLRFGMRAKSI 330  Neurospora crassa
1MKJ_A     298 IVICCSPSsyNESETKSTLLFGQRAKTI 325  human
Q9US60     298 LIINCSPDsyNATETLSTLRFGHRAKSI 325  Schizosaccharomyces pombe 972h-
NP_850742  307 LLCCCSPStlNASETLSTLRFGMRAKHI 334  thale cress
CAD98568   334 LIVTCSPSivNESETIGTLRFGIRAKMV 361  Cryptosporidium parvum
AAR39436   302 LIINCSPSsyNEAETISTLRFGSRAKNI 329  Dictyostelium discoideum
EAK97338   360 LIINCSPSsfNELETLSTLRFGTRAKSI 387  Candida albicans SC5314

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