Conserved Protein Domain Family
MYSc_Myh8
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cd14918: MYSc_Myh8 
class II myosin heavy chain 8, motor domain
Myosin motor domain of perinatal skeletal muscle myosin heavy chain 8 (also called MyHC-peri, MyHC-pn). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276882
Aligned: 18 rows
Threshold Bit Score: 1328.21
Created: 18-Mar-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                           #
P13535        102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  human
NP_796343     102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  house mouse
P13542        102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  house mouse
Q076A4        102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  dog
EDL10431      102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  house mouse
AAI50738      102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  house mouse
NP_001070703  102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  dog
NP_001093955  102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  Norway rat
DAA18731      102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  cattle
EHB04541      102 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVGAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 181  naked mole-rat

Feature 1         #######                                                 ###########             
P13535        182 ESGAGKTVNTKRVIQYFATIavtgekk--kdesgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  human
NP_796343     182 ESGAGKTVNTKRVIQYFATIavtgdkk--keesgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
P13542        182 ESGAGKTVNTKRVIQYFATIavtgdkk--keesgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
Q076A4        182 ESGAGKTVNTKRVIQYFATIavtgekkkeeatsgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 261  dog
EDL10431      182 ESGAGKTVNTKRVIQYFATIavtgdkk--keesgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
AAI50738      182 ESGAGKTVNTKRVIQYFATIavtgdkk--keesgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  house mouse
NP_001070703  182 ESGAGKTVNTKRVIQYFATIavtgekkkeeatsgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 261  dog
NP_001093955  182 ESGAGKTVNTKRVIQYFATIavtgekk--keesgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  Norway rat
DAA18731      182 ESGAGKTVNTKRVIQYFATIavtgekk--keepgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  cattle
EHB04541      182 ESGAGKTVNTKRVIQYFATIavtgekk--keesgkMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 259  naked mole-rat

Feature 1                                                                                         
P13535        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  human
NP_796343     260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  house mouse
P13542        260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  house mouse
Q076A4        262 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 341  dog
EDL10431      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  house mouse
AAI50738      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  house mouse
NP_001070703  262 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 341  dog
NP_001093955  260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  Norway rat
DAA18731      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  cattle
EHB04541      260 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEiTVPSIDDQEELMATDSAI 339  naked mole-rat

Feature 1                                                                                         
P13535        340 DILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  human
NP_796343     340 DILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQCLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
P13542        340 DILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQCLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
Q076A4        342 DILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQT 421  dog
EDL10431      340 DILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQCLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
AAI50738      340 DILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQCLNSADLLKALCYPRVKVGNEYVTKGQT 419  house mouse
NP_001070703  342 DILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQT 421  dog
NP_001093955  340 DILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  Norway rat
DAA18731      340 DILGFTSEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  cattle
EHB04541      340 DILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREeqaEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 419  naked mole-rat

Feature 1                                                     ######                              
P13535        420 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  human
NP_796343     420 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
P13542        420 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
Q076A4        422 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 501  dog
EDL10431      420 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
AAI50738      420 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  house mouse
NP_001070703  422 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 501  dog
NP_001093955  420 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  Norway rat
DAA18731      420 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  cattle
EHB04541      420 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 499  naked mole-rat

Feature 1                                                                                         
P13535        500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksanfqkpkvvKGKAEAH 579  human
NP_796343     500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksnnfqkpkptKGKAEAH 579  house mouse
P13542        500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksnnfqkpkptKGKAEAH 579  house mouse
Q076A4        502 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksanfqkpkvvKGKAEAH 581  dog
EDL10431      500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksnnfqkpkptKGKAEAH 579  house mouse
AAI50738      500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksnnfqkpkpaKGKAEAH 579  house mouse
NP_001070703  502 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksanfqkpkvvKGKAEAH 581  dog
NP_001093955  500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksnnfqkpkptKGKAEAH 579  Norway rat
DAA18731      500 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksanfqkpkvvKGRAEAH 579  cattle
EHB04541      500 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgksanfqkpkpaKGKAEAH 579  naked mole-rat

Feature 1                                                                                         
P13535        580 FSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaeadssakKGAKKKGSSFQTVSALFRENLN 659  human
NP_796343     580 FSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaeadggakKGAKKKGSSFQTVSALFRENLN 659  house mouse
P13542        580 FSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaeadggakKGAKKKGSSFQTVSALFRENLN 659  house mouse
Q076A4        582 FSLIHYAGTVDYNIGGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaeadsgakKGAKKKGSSFQTVSALFRENLN 661  dog
EDL10431      580 FSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaeadggakKGAKKKGSSFQTVSALFRENLN 659  house mouse
AAI50738      580 FSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaeadggakKGAKKKGSSFQTVSALFRENLN 659  house mouse
NP_001070703  582 FSLIHYAGTVDYNIGGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaeadsgakKGAKKKGSSFQTVSALFRENLN 661  dog
NP_001093955  580 FSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaeadggakKGAKKKGSSFQTVSALFRENLN 659  Norway rat
DAA18731      580 FSLIHYAGTVDYNIAGWLDKNKDPLNDTVVGLYQKSSMKTlaslfstyasaeadsgakKGAKKKGSSFQTVSALFRENLN 659  cattle
EHB04541      580 FSLVHYAGTVDYNIAGWLDKNKDPLNDTVVGLYQKSAMKTlaslfstyasaegdsgakKGAKKKGSSFQTVSALFRENLN 659  naked mole-rat

Feature 1                                                                                         
P13535        660 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 739  human
NP_796343     660 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 739  house mouse
P13542        660 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 739  house mouse
Q076A4        662 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 741  dog
EDL10431      660 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 739  house mouse
AAI50738      660 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 739  house mouse
NP_001070703  662 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 741  dog
NP_001093955  660 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 739  Norway rat
DAA18731      660 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPDGQFI 739  cattle
EHB04541      660 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 739  naked mole-rat

Feature 1                                       
P13535        740 DSKKASEKLLASIDIDHTQYKFGHTKVFFK 769  human
NP_796343     740 DSKKASEKLLGSIDIDHTQYKFGHTKVFFK 769  house mouse
P13542        740 DSKKASEKLLGSIDIDHTQYKFGHTKVFFK 769  house mouse
Q076A4        742 DSKKASEKLLASIDIDHTQYKFGHTKVFFK 771  dog
EDL10431      740 DSKKASEKLLGSIDIDHTQYKFGHTKVFFK 769  house mouse
AAI50738      740 DSKKASEKLLGSIDIDHTQYKFGHTKVFFK 769  house mouse
NP_001070703  742 DSKKASEKLLASIDIDHTQYKFGHTKVFFK 771  dog
NP_001093955  740 DSKKASEKLLGSIDIDHTQYKFGHTKVFFK 769  Norway rat
DAA18731      740 DSKKASEKLLASIDIDHTQYKFGHTKVFFK 769  cattle
EHB04541      740 DSKKASEKLLASIDIDHTQYKFGHTKVFFK 769  naked mole-rat

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