1BR1,1BR2,1I84,3DTP,3J04


Conserved Protein Domain Family
MYSc_Myh11
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cd14921: MYSc_Myh11 
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class II myosin heavy chain 11, motor domain
Myosin motor domain of smooth muscle myosin heavy chain 11 (also called SMMHC, SMHC). The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. Inversion of the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Mutations in MYH11 have been described in individuals with thoracic aortic aneurysms leading to acute aortic dissections with patent ductus arteriosus. MYH11 mutations are also thought to contribute to human colorectal cancer and are also associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant myh11 zebrafish. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
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Statistics
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PSSM-Id: 276885
Aligned: 38 rows
Threshold Bit Score: 1311.93
Created: 8-Jan-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #########                                           #
1BR1_A      97 ASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 176  chicken
1BR2_A      97 ASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 176  chicken
1I84_S      97 ASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 176  chicken
3DTP_B      97 ASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 176  chicken
3J04_A      97 ASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 176  chicken
P10587      98 ASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 177  chicken
EHA97370    99 ASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 178  naked mole-rat
JAA53323   104 ASVLHNLRERYFSGLIYTYSGLFCVVVNPYKQLPIYSEKIVEMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 183  common vampire bat
ELK33290   119 ASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPIYSEKIVEMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 198  Myotis davidii
ELW67681   180 ASVLHNLRERYFSGLIYTYSGLFCVVVNPYKYLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 259  Chinese tree shrew

Feature 1      #######                                                    ###########          
1BR1_A     177 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsitqgpsfsyGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 256  chicken
1BR2_A     177 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsitqgpsfsyGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 256  chicken
1I84_S     177 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsitqgpsfsyGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 256  chicken
3DTP_B     177 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsitqgpsfsyGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 256  chicken
3J04_A     177 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsitqgpsfsyGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 256  chicken
P10587     178 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsitqgpsfsyGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 257  chicken
EHA97370   179 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsi-------tGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 251  naked mole-rat
JAA53323   184 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsi-------tGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 256  common vampire bat
ELK33290   199 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsi-------tGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 271  Myotis davidii
ELW67681   260 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsi-------tGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 332  Chinese tree shrew

Feature 1                                                                                      
1BR1_A     257 VTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLE 336  chicken
1BR2_A     257 VTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLE 336  chicken
1I84_S     257 VTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLE 336  chicken
3DTP_B     257 VTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLE 336  chicken
3J04_A     257 VTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLE 336  chicken
P10587     258 VTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLE 337  chicken
EHA97370   252 VTGYIVGANIETYLLEKSRAIRQAREERTFHIFYYLIAGAKEKMKNDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETLE 331  naked mole-rat
JAA53323   257 VTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKDKMKNDLLLEGFNNYTFLSNGYVPIPAAQDDEMFQETLE 336  common vampire bat
ELK33290   272 VTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYMIAGAKEKMKSDLLLEGFSNYTFLSNGYVPIPAAQDDEMFQETLE 351  Myotis davidii
ELW67681   333 VTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYLIAGAKDKMKNDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETLE 412  Chinese tree shrew

Feature 1                                                                                      
1BR1_A     337 AMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKA 416  chicken
1BR2_A     337 AMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKA 416  chicken
1I84_S     337 AMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKA 416  chicken
3DTP_B     337 AMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKA 416  chicken
3J04_A     337 AMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKA 416  chicken
P10587     338 AMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKA 417  chicken
EHA97370   332 AMSIMGFSEEEQLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGINVTDFTRAILTPRIKVGRDVVQKA 411  naked mole-rat
JAA53323   337 AMGIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRCILTPRIKVGRDVVQKA 416  common vampire bat
ELK33290   352 AMGIMGFNEDEQLSVLKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRAVLTPRIKVGRDVVQKA 431  Myotis davidii
ELW67681   413 AMGIMGFTEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLTGINVTDFTRAILTPRIKVGRDVVQKA 492  Chinese tree shrew

Feature 1                                                     ######                           
1BR1_A     417 QTKEQADFAIEALAKAKFERLFRWILTRVNKALDKTKRQGASFLGILDIAGFEIFEiNSFEQLCINYTNEKLQQLFNHTM 496  chicken
1BR2_A     417 QTKEQADFAIEALAKAKFERLFRWILTRVNKALDKTKRQGASFLGILDIAGFEIFEiNSFEQLCINYTNEKLQQLFNHTM 496  chicken
1I84_S     417 QTKEQADFAIEALAKAKFERLFRWILTRVNKALDKTKRQGASFLGILDIAGFEIFEiNSFEQLCINYTNEKLQQLFNHTM 496  chicken
3DTP_B     417 QTKEQADFAIEALAKAKFERLFRWILTRVNKALDKTKRQGASFLGILDIAGFEIFEiNSFEQLCINYTNEKLQQLFNHTM 496  chicken
3J04_A     417 QTKEQADFAIEALAKAKFERLFRWILTRVNKALDKTKRQGASFLGILDIAGFEIFEiNSFEQLCINYTNEKLQQLFNHTM 496  chicken
P10587     418 QTKEQADFAIEALAKAKFERLFRWILTRVNKALDKTKRQGASFLGILDIAGFEIFEiNSFEQLCINYTNEKLQQLFNHTM 497  chicken
EHA97370   412 QTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILDIAGFEIFEvNSFEQLCINYTNEKLQQLFNHTM 491  naked mole-rat
JAA53323   417 QTKEQADFAIEALAKATFERLFRWILSRVNKALDKTHRQGASFLGILDIAGFEIFEvNSFEQLCINYTNEKLQQLFNHTM 496  common vampire bat
ELK33290   432 QTKEQADFAMEALAKATYERLFRWILGRVNKALDKTHRQGASFLGILDIAGFEIFEvNSFEQLCINYTNEKLQQLFNHTM 511  Myotis davidii
ELW67681   493 QTKEQADFAIEALAKAIYERLFRWILTRVNKALDKTHRQGASFLGILDIAGFEIFEvNSFEQLCINYTNEKLQQLFNHTM 572  Chinese tree shrew

Feature 1                                                                                      
1BR1_A     497 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQEQGNHAKFQKSKQLKD 576  chicken
1BR2_A     497 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQEQGNHAKFQKSKQLKD 576  chicken
1I84_S     497 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQEQGNHAKFQKSKQLKD 576  chicken
3DTP_B     497 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQEQGNHAKFQKSKQLKD 576  chicken
3J04_A     497 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQEQGNHAKFQKSKQLKD 576  chicken
P10587     498 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQEQGNHAKFQKSKQLKD 577  chicken
EHA97370   492 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKD 571  naked mole-rat
JAA53323   497 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDTSFVEKLCTEQGNHPKFQKPKQLKD 576  common vampire bat
ELK33290   512 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKD 591  Myotis davidii
ELW67681   573 FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGNHPKFQKPKQLKD 652  Chinese tree shrew

Feature 1                                                                                      
1BR1_A     577 KTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 656  chicken
1BR2_A     577 KTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 656  chicken
1I84_S     577 KTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 656  chicken
3DTP_B     577 KTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 656  chicken
3J04_A     577 KTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 656  chicken
P10587     578 KTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 657  chicken
EHA97370   572 KTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSMPSASKTKKGMFR 651  naked mole-rat
JAA53323   577 KTEFSIIHYAGKVDYNATAWLTKNMDPLNDNVTALLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 656  common vampire bat
ELK33290   592 KTEFSIIHYAGKVDYNAAAWLTKNMDPLNDNVTALLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 671  Myotis davidii
ELW67681   653 KTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFR 732  Chinese tree shrew

Feature 1                                                                                      
1BR1_A     657 TVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 736  chicken
1BR2_A     657 TVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 736  chicken
1I84_S     657 TVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 736  chicken
3DTP_B     657 TVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 736  chicken
3J04_A     657 TVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 736  chicken
P10587     658 TVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 737  chicken
EHA97370   652 TVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 731  naked mole-rat
JAA53323   657 TVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 736  common vampire bat
ELK33290   672 TVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 751  Myotis davidii
ELW67681   733 TVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 812  Chinese tree shrew

Feature 1                                              
1BR1_A     737 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 776  chicken
1BR2_A     737 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 776  chicken
1I84_S     737 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 776  chicken
3DTP_B     737 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 776  chicken
3J04_A     737 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 776  chicken
P10587     738 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 777  chicken
EHA97370   732 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 771  naked mole-rat
JAA53323   737 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 776  common vampire bat
ELK33290   752 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 791  Myotis davidii
ELW67681   813 AANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFR 852  Chinese tree shrew

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