Conserved Protein Domain Family
MYSc_Myh16

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cd14934: MYSc_Myh16 
class II myosin heavy chain 16, motor domain
Myosin motor domain of myosin heavy chain 16 pseudogene (also called MHC20, MYH16, and myh5), encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. This cd contains Myh16 in mammals. MYH16 has intermediate fibres between that of slow type 1 and fast 2B fibres, but exert more force than any other fibre type examined. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.
Statistics
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PSSM-Id: 276896
Aligned: 6 rows
Threshold Bit Score: 1355.85
Created: 8-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #########                                           #
EFB25464       86 ASVLNNLRQRYTNMRIYTYSGLFCVTVNPYKWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYHDMLMNRENQSMLITG 165  giant panda
NP_001009221  102 ASVLNNLRQRYTNMRIYTYSGLFCVTVNPYKWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYQDMLMNRENQSMLITG 181  domestic cat
ELK11626      102 ASVLDNLRQRYINMRIYTYSGLFCVTVNPYKWLPIYGVRVVNMYKGKKRTEMPPHLFSISDNAYHDMLMDRENQSMLITG 181  black flying fox
ELW64891       73 ASVLDNLRQRYTNMRIYTYSGLFCVTVNPYRWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYHDMLMDRENQSMLITG 152  Chinese tree ...
EMP33063      102 ASVLDNLRQRYSHMRIYTYSGLFCVTINPYKWLPIYGARVVQMYKGKKRTEMPPHLFSISDNAYHDMLQDRENQSMLITG 181  green sea turtle
BAN82054      102 ASVLDTLKQRYIMMRIYTYSGLFCVTINPYKWLPIYGARVAQMYKGKKRTEVPPHLFSISDNAYHDMLMERENQSMLITG 181  Protobothrops...
Feature 1         #######                                                 ###########             
EFB25464      166 ESGAGKTENTKKVIQYFANVRGTGKQQhptlcfSLGQGSLEDQIIQANPVLEAFGNAKTIRNNNSSRFGKFIRIHFGTTG 245  giant panda
NP_001009221  182 ESGAGKTENTKKVIQYFANVGGTGKQS------SDGKGSLEDQIIQANPVLEAFGNAKTIRNNNSSRFGKFIRIHFGTTG 255  domestic cat
ELK11626      182 ESGAGKTENTKKVIQYFANIGGIGKQS------SDKKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTAG 255  black flying fox
ELW64891      153 ESGAGKTENTKKVIQYFANIGGTGKQS------SDKKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTTG 226  Chinese tree ...
EMP33063      182 ESGAGKTENTKKVIQYFANIGSTGKQA------LDGKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTTG 255  green sea turtle
BAN82054      182 ESGAGKTENTKKVIQYFANIGSTGKVS------ADGKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGSTG 255  Protobothrops...
Feature 1                                                                                         
EFB25464      246 KLAGADIESYLLEKSRVISQQAAERGYHIFYQILSNRKPELIESLLLVPNPKEYHWVSQGVTVVENMDDGEELQITDVAF 325  giant panda
NP_001009221  256 KLAGADIESYLLEKSRVISQQPAERGYHIFYQILSNKKPELIETLLLVPNPKEYHWVSQGVTVVENMDDGEELQITDVAF 335  domestic cat
ELK11626      256 KLAGADIESYLLEKSRVISQQAAERSYHIFYQILSNKKPELVESLLLVPNPKEYHWVSQGVTMVDNMDDKEELQITDDAF 335  black flying fox
ELW64891      227 KLAGADIESYLLEKSRVISQQAAERGYHIFYQILSNKKPELVESLLLVPNPKEYHWVSQGVTVVDNMDDGEELQITDVAF 306  Chinese tree ...
EMP33063      256 KLAGADIESYLLEKSRVISQQAAERSYHIFYQILSKKKPDLIESLLLVPDPKHYHWICQGVTTVDNMDDGEELLVTDVAS 335  green sea turtle
BAN82054      256 KLAGADIESYLLEKSRVISQQPAERGYHIFYQLLSNKKPDLVESLLCVPDPKEYQWTSQGVIVVDNMDDGEELLLTDVAF 335  Protobothrops...
Feature 1                                                                                         
EFB25464      326 DVLGFSPEEKIGVYKLMGGIMHFGNMKFKQKPREEQAEVDTTEVADKVSHLMGLNSGELQKGITRPRVKVGNEFVQKGQN 405  giant panda
NP_001009221  336 DVLGFSADEKIGIYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQN 415  domestic cat
ELK11626      336 DVLGFSAEEKIGVYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQN 415  black flying fox
ELW64891      307 DVLGFSAEEKIGVYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQN 386  Chinese tree ...
EMP33063      336 AVLGFSPEEKLGIYKLTGGIMHFGNMKFRQKAREEQADVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQN 415  green sea turtle
BAN82054      336 DVLGFTGEEKNSVYKLTGGILHFGNMKFKQKPREEQADVDTTEVADKVAHLMGINSGDLQKGITRPRVKVGNEFVQKGQN 415  Protobothrops...
Feature 1                                                     ######                              
EFB25464      406 MEQCHNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCVNFTNEKLQQFFNHHMFVL 485  giant panda
NP_001009221  416 MEQCHNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVL 495  domestic cat
ELK11626      416 MEQCNNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVL 495  black flying fox
ELW64891      387 MEQCNNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVL 466  Chinese tree ...
EMP33063      416 MEQCYNSVGALGKATYDKMFKWMVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVL 495  green sea turtle
BAN82054      416 LDQCNNSIGALGKAVYDKMFKWMVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVL 495  Protobothrops...
Feature 1                                                                                         
EFB25464      486 EQEEYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKG-GKGKGPE 564  giant panda
NP_001009221  496 EQEEYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKG-GKGKGPE 574  domestic cat
ELK11626      496 EQEEYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKGgGKGKGPE 575  black flying fox
ELW64891      467 EQEEYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKG-GKGKGPE 545  Chinese tree ...
EMP33063      496 EQEEYKREGIVWEFIDFGMDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKG-GRGKGPE 574  green sea turtle
BAN82054      496 EQEEYKREGINWVFIDFGLDLQACIELLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSPNFLKPKG-GKGKGAE 574  Protobothrops...
Feature 1                                                                                         
EFB25464      565 AHFELVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKSsl-gILALLFKEEEAPAGSKKQKRGSSFMTVSNFYREQLNKL 643  giant panda
NP_001009221  575 AHFELVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKSsl-vLLALLFKEEEAPAGSKKQKRGSSFMTVSNFYREQLNKL 653  domestic cat
ELK11626      576 AHFELIHYAGTVGYNITGWLEKNKDPLNETVVGLFQKStl-gILALLFKEEEAPTASKKQKRGSSFMTVSNFYREQLNKL 654  black flying fox
ELW64891      546 AHFELVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKStl-gILALLFKEEEAPAGSKKQKRGSSFMTVSNFYREQLNKL 624  Chinese tree ...
EMP33063      575 AHFELVHYAGTVAYNITGWLEKNKDPLNETVVGLFQKSsmvlLGNLFKEEEAAAGGAKKQKRGSSFMTVSNFYREQLNKL 654  green sea turtle
BAN82054      575 AHFELVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKSamplLCTLFKEEEAAASGTKKQKRGSSFMTVSNFYREQLNKL 654  Protobothrops...
Feature 1                                                                                         
EFB25464      644 MTTLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRMQYPEFKQRYQVLNPNVIPQGFVDNK 723  giant panda
NP_001009221  654 MATLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRMQYPEFKQRYQVLNPNVIPQGFVDNK 733  domestic cat
ELK11626      655 MTTLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQGFVDNK 734  black flying fox
ELW64891      625 MTTLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQGFVDNK 704  Chinese tree ...
EMP33063      655 MTTLHSTSPHFVRCIIPNEFKQSGVADAHLILHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQGFVDNK 734  green sea turtle
BAN82054      655 MATLHSTSPHFVRCIVPNEFKQSGVVDAHLILHQLACNGVLEGIRICQKGFPNRLQYPEFKQRYQLLNPNVIPQGFVDNK 734  Protobothrops...
Feature 1                                    
EFB25464      724 KASELLLGSIDLDVNEYKIGHTKVFFR 750  giant panda
NP_001009221  734 KASELLLGSIDLDVNEYKIGHTKVFFR 760  domestic cat
ELK11626      735 KASELLLGSIDLDVNEYKIGHTKVFFR 761  black flying fox
ELW64891      705 KASELLLGSIDLDVNDYKIGHTKVFFR 731  Chinese tree shrew
EMP33063      735 KASELLLASTELGENEFKIGHTKVFFR 761  green sea turtle
BAN82054      735 KASELVLGSLGLEENEYKIGNTKVFFR 761  Protobothrops flavoviridis

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