Conserved Protein Domain Family
TNFRSF25

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cd13420: TNFRSF25 
tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
TNFRSF25 (also known as death receptor 3 (DR3), death domain receptor 3 (DDR3), apoptosis-mediating receptor, lymphocyte associated receptor of death (LARD), apoptosis inducing receptor (AIR), APO-3, translocating chain-association membrane protein (TRAMP), WSL-1, WSL-LR or TNFRSF12) is preferentially expressed in thymocytes and lymphocytes, and may play a role in regulating lymphocyte homeostasis. It has been detected in lymphocyte-rich tissues such as colon, intestine, thymus and spleen, as well as in the prostate. Various death domain containing adaptor proteins mediate the signal transduction of this receptor; it activates nuclear factor kappa-B (NFkB) and induces cell apoptosis by associating with TNFRSF1A-associated via death domain (TRADD), which is known to mediate signal transduction of tumor necrosis factor receptors. DR3 associates with tumor necrosis factor (TNF)-like cytokine 1A (TL1A also known as TNFSF15) on activated lymphocytes and induces pro-inflammatory signals; TL1A also binds decoy receptor DcR3 (also known as TNFRSF6B). DR3/DcR3/TL1A expression is increased in both serum and inflamed tissues in autoimmune diseases such as in several autoimmune diseases, including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), allergic asthma, experimental autoimmune encephalomyelitis, type 1 diabetes, ankylosing spondylitis (AS), and primary biliary cirrhosis (PBC), making modulation of TL1A-DR3 interaction a potential therapeutic target.
Statistics
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PSSM-Id: 276925
Aligned: 7 rows
Threshold Bit Score: 148.023
Created: 8-Nov-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:CRD1 [structural motif]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ###              ################### ####                                    
Q93038      32 RCDCAGdfhkk-----iglfCCRGCPAGHYLKAPCTEPCGNSTCLVCPQdTFLAWENHHnsECARCQACDEqaSQVALEN 106  human
EHB16674    48 RCDCGGdiqkr-----ygpfCCRGCPMGYYLKARCTEHCGDATCLPCPQgTFLARENHYnvHCTRCQACDEeaSQVVLKN 122  naked mole-rat
AAH17526    50 RCDCASesqkr-----ygpfCCRGCPKGHYMKAPCAEPCGNSTCLPCPSdTFLTRDNHFktDCTRCQVCDEeaLQVTLEN 124  house mouse
EFB21739    22 KCDCAYnfqkr-----ngpfCCKGCPAGHYLKAPCPKPCGTVTCLPCPRgTFLARENHHetRCTRCQACDEevSQVALTN 96   giant panda
XP_423315   53 KSSCPSgmswi----hsagrCCTQCPPGKFLQTRCTSHGNDSVCVACPAgTFLSHPNTLs-KCNACHMCDHqtFQTVVSN 127  chicken
ELK10577    12 GPPCSEeggp-------qpvSAPCLAGGHYLAGPCTKPCGNITCLPCPPgTFLARENHHetSCARCLACDEqaSQVALEN 84   black flying fox
ERE81896  1028 KLTLAQlyrirttlllnstlTASGCPEGHYMKTSCTEPCGNATCLPCPRgTFLTWGNHFksDCTRCQACDEmgFQVTLEN 1107 Chinese hamster
Feature 1                                                
Q93038     107 CSAVADTRCGCKPGWFVECQvsqc---vssSPFYCQPCLDCG 145  human
EHB16674   123 CSAVADTRCGCAPGQLVDCSvkpc---vasSPFRCLPCLDCK 161  naked mole-rat
AAH17526   125 CSAKSDTHCGCQSGWCVDCStepc---gksSPFSCVPCGATT 163  house mouse
EFB21739    97 CSTVADTHCGCEPGWFAECLvkpc---kvgSPFRCNPCSDCR 135  giant panda
XP_423315  128 CSATSNIACGCESGHFRECQnkd----dscSDFSCKKCNTCP 165  chicken
ELK10577    85 CSALADTHCGCKPGWFMDCLvpqc---ignSPFHCHPCLDCG 123  black flying fox
ERE81896  1108 CSAVSDTRCGCQSGLTTHLSasdsahtllaPQDSGKVCTTVQ 1149 Chinese hamster

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