3O37,2MD7,2RO1,3U5M,4PTB


Conserved Protein Domain Family
PHD_TIF1_like

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cd15541: PHD_TIF1_like 
Click on image for an interactive view with Cn3D
PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
The TIF1 family of transcriptional cofactors includes TIF1alpha (TRIM24), TIF1beta (TRIM28), TIF1gamma (TRIM33), and TIF1delta (TRIM66), which are characterized by an N-terminal RING-finger B-box coiled-coil (RBCC/TRIM) motif and plant homeodomain (PHD) finger followed by a bromodomain in the C-terminal region. TIF1 proteins couple chromatin modifications to transcriptional regulation, signaling, and tumor suppression. They exert a deacetylase-dependent silencing effect when tethered to a promoter region. TIF1alpha, TIF1beta, and TIF1delta can homodimerize and contain a PXVXL motif necessary and sufficient for heterochromatin protein 1(HP1) binding. TIF1alpha and TIF1beta bind nuclear receptors and Kruppel-associated boxes (KRAB) specifically and respectively. In contrast, TIF1delta appears to lack nuclear receptor- and KRAB-binding activity. Moreover, TIF1delta is specifically involved in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis. TIF1gamma is structurally closely related to TIF1alpha and TIF1beta, but has very little functional features in common with them. It does not interact with the KRAB silencing domain of KOX1 or the heterochromatinic proteins HP1alpha, beta, and gamma. It cannot bind to nuclear receptors (NRs). This family also includes Sp100/Sp140 family proteins, the nuclear body SP100 and SP140. Sp110 is a leukocyte-specific component of the nuclear body. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers. SP140 is an interferon inducible nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. It is also implicated in innate immune response to human immunodeficiency virus type 1 (HIV-1) by binding to the virus viral infectivity factor (Vif) protein. Both Sp110 and Sp140 contain a SAND domain, a plant homeodomain (PHD) finger, and a bromodomain (BRD).
Statistics
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PSSM-Id: 277016
Aligned: 28 rows
Threshold Bit Score: 53.8873
Threshold Setting Gi: 557803968
Created: 14-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitehistone H3
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H [CHX] C CClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #  #                #  #    #  #               #  #
3O37_C          6 WCAVCQNgg--------eLLCCEKCPKVFHLSCHVPtltnf-psgeWICTFC 48   human
2MD7_B         10 ECEVCRDgg--------eLFCCDTCSRVFHEDCHIPpvea--ertpWNCIFC 51   human
2RO1_A          4 ICRVCQKpg--------dLVMCNQCEFCFHLDCHLPalqdv-pgeeWSCSLC 46   human
4PTB_A          5 ICEVCNKwg--------rLFCCDTCPRSFHEHCHIPsvea--nknpWSCIFC 46   human
NP_001107447  230 VCFVCNSeg--------nLVCCDECPRAFHHHCHLPavped-ssgkWSCTIC 272  western clawed frog
XP_004571143 1196 ACSVCASpg--------tSIICSACGRGYHRDCHVPpvgld-fwseWACSLC 1238 zebra mbuna
XP_002664967 1023 FCVVCQSag--------aSLLCAKCGSAFHSDCHIPpiftk-predWVCLLC 1065 zebrafish
XP_006010037  584 LCSVCQNpg--------eLAACSQCRRHFHTRCHIPvifea-psaeWKCFLC 626  coelacanth
XP_003967661  703 VCTVCQTgg--------eLLLCDKCSKHFHLFCHIPalrnv-psgcWSCSFC 745  torafugu
XP_004535100  174 TCDVCDSfedgepktdqpLITCSKCVKSYHLTCHIPnvykyqqifrWKCSKC 225  Mediterranean fruit fly

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