3U5M,3U5P


Conserved Protein Domain Family
PHD_TIF1gamma

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cd15624: PHD_TIF1gamma 
Click on image for an interactive view with Cn3D
PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
TIF1gamma, also termed tripartite motif-containing 33 (trim33), or ectodermin, or RFG7, or PTC7, is an E3-ubiquitin ligase that functions as a regulator of transforming growth factor beta (TGFbeta) signaling; it inhibits the Smad4-mediated TGFbeta response by interaction with Smad2/3 or ubiquitylation of Smad4. Moreover, TIF1gamma is an important regulator of transcription during hematopoiesis, as well as a key factor of tumorigenesis. Like other TIF1 family members, TIF1gamma also contains an intrinsic transcriptional silencing function. It can control erythroid cell fate by regulating transcription elongation. It can bind to the anaphase-promoting complex/cyclosome (APC/C) and promotes mitosis. TIF1gamma contains an N-terminal RBCC (RING finger, B-box zinc-fingers, coiled-coil), a plant homeodomain (PHD) finger, followed by a bromodomain in the C-terminal region.
Statistics
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PSSM-Id: 277094
Aligned: 4 rows
Threshold Bit Score: 96.2698
Created: 20-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitehistone H3
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #  #        #  #    #  #              #  #   
3U5M_A       9 WCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDI 54   human
Q56R14     852 WCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGEWICTFCRDL 897  African clawed frog
ETE67470   633 WCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGEWICTFCRDL 678  king cobra
3U5P_A       9 WCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDI 54   human

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