Conserved Protein Domain Family

cd15744: FYVE_RUFY3 
FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
RUFY3, also termed Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. Moreover, the FYVE domain of RUFY3 resembles the FYVE-related domain as it lacks the WxxD motif (x for any residue).
PSSM-Id: 277283
Aligned: 11 rows
Threshold Bit Score: 68.2133
Threshold Setting Gi: 595447319
Created: 1-May-2013
Updated: 2-Oct-2020
Aligned Rows:
putative Zn
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C [CH] C CClick to see conserved feature residue pattern help
  • Comment:Based on the structure evidence that Homo sapiens RUFY1 (2YQM) binds two Zn2+ ions through its FYVE domain.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1          #  #                      #  #    #  #                   #  # 
NP_001032519  561 LCQLCQe------------dGSLTKNVCKNCSGTFCDACSTNELPLPssi---kleRVCNPCH 608  human
CAG07776      541 LCSLCEdd----------esLLKTKKQCKNCSGVFCEGCVRNELPLPssi---lpaTVCNTCF 590  spotted green pufferfish
XP_004941233  588 ICQLCQee----------ssRSKKKNICKNCGGIFCEACSANELPLPssi---npeRVCNPCH 637  chicken
XP_006627258  576 LCRLCKee----------dsLARVKKQCNNCREDFCENCLANELPLPssi---npvQVCTVCH 625  spotted gar
EQC37250      142 RCAVCPqdd--------vaaAALLKFRCGNCEDTFCDRHSLQRLPLPhkgy-yyamRVCDECY 195  Saprolegnia diclina VS20
ETV83524      148 KCLRCQpsaddp--aaiaaaAALTKFKCSSCDATYCDRHSQHKLPLPhrsy-ysamRICDDCY 207  Aphanomyces astaci
EQC41070       60 ECHVCHda----------ltLLKFKHNCRNCGKSVCGAHSKNQLPLPelgi-lkevRVCDVCY 111  Saprolegnia diclina VS20
XP_002765625  270 SCSCCGsdflwnsvlkseahRLLSRHNCYSCGNAVCDGCSKNRISMLmsp---etaRCCDRCW 329  Perkinsus marinus ATCC 50983
EJY65204      190 SCQLCQkal---------gfLKKPRHNCYNCGACVCDKCSINKLQLSiqdp--tkyRVCNFCF 241  Oxytricha trifallax
XP_004990894  462 SCVECRrhgrh-----tsfhPFRPRVECANCGSSVCGACSSNRLLLPagtggrskaRVCQSCY 519  Salpingoeca rosetta
EXX57049       34 CCSSCGit----------frLFRPKYNCYNCGNVTCGRCSSNGTEIPkfgy-fepvRTCDLCY 85   Rhizophagus irregularis DAOM 1...

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