1WFK


Conserved Protein Domain Family
FYVE_ZFY19
?
cd15749: FYVE_ZFY19 
Click on image for an interactive view with Cn3D
FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
ZFY19, also termed mixed lineage leukemia (MLL) partner containing FYVE domain, is encoded by a novel gene, MLL partner containing FYVE domain (MPFYVE). The FYVE domain of ZFY19 resembles FYVE-related domains that are structurally similar to the canonical FYVE domains but lack the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. The biological function of ZFY19 remains unclear.
Links
?
Statistics
?
PSSM-Id: 277288
Aligned: 7 rows
Threshold Bit Score: 67.5308
Created: 1-May-2013
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:1WFK; Mus musculus ZFY19 binds two Zn2+ ions through its FYVE-related domain.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #            #  #    #  #                 #  # 
1WFK_A        11 RCYGCAVKFtlFKKEYGCKNCGRAFCNGCLSFsalvpragntqqKVCKQCH 61  house mouse
XP_001635135  11 QCFGCGAEFgfFKREHGCNNCGRLFCYFCTTKtivlpnkgnkkqKVCDKCY 61  starlet sea anemone
NP_001186581   4 RCYGCACKFslFKKECGCRSCGRAFCAGCLSCsapvprcgsapqKVCKECH 54  chicken
NP_001116959   4 RCFGCASKFsiFKKECGCKSCGHSFCGSCLGFsavlpqygntkqKVCRRCH 54  western clawed frog
AAI53444       4 RCYCCASKFtlFKKELGCKSCGRSFCSGCLTFnavvpkygngqqKVCKQCY 54  zebrafish
FAA00234      12 NCFICTAKFgfFKKQVDCINCNKTTCKECQNYmmvvpskgsqpqNVCKQCF 62  Ciona intestinalis
XP_004205457   2 SCFACAAKFswTKKEFDCKYCHKVFCKDCLKEvpgs-----qkeNGCKKCL 47  green hydra

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap