1ZBD


Conserved Protein Domain Family
FYVE_RP3A

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cd15762: FYVE_RP3A 
Click on image for an interactive view with Cn3D
FYVE-related domain found in rabphilin-3A and similar proteins
Rabphilin-3A, also termed exophilin-1, is an effector protein that binds to the GTP-bound form of Rab3A, which is one of the most abundant Rab proteins in neurons and predominantly localized to synaptic vesicles. Rabphilin-3A is homologous to alpha-Rab3-interacting molecules (RIMs). It is a multi-domain protein containing an N-terminal Rab3A effector domain, a proline-rich linker region, and two tandem C2 domains. The effector domain binds specifically to the activated GTP-bound state of Rab3A and harbors a conserved FYVE zinc finger. The C2 domains are responsible for the binding of phosphatidylinositol-4,5-bisphosphate (PIP2) , a key player in the neurotransmitter release process. Thus, Rabphilin-3A has also been implicated in vesicle trafficking. The FYVE domain of Rabphilin-3A resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.
Statistics
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PSSM-Id: 277301
Aligned: 4 rows
Threshold Bit Score: 159.351
Created: 2-May-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitepolypeptide
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:1ZBD; Rattus norvegicus Rabphilin-3A binds two Zn2+ through its effector domain.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #             #  #    #  #              #  #                           
1ZBD_B     52 GDGVNRCILCGEQLGXLGsASVVCEDCKKNVCTKCGVETsnnrphpVWLCKICLEQREVWKRSGAWFFKGFPKQVLPQPX 131 Norway rat
XP_691832  65 GDGVSRCLLCGEQLGGAGdRAVVCEDCKKNMCTKCGVQTntr-prsVWLCKICSEQREVWKRSGAWFFKGLPKQFLPSPM 143 zebrafish
EOB06466   15 GDGVNRCILCGEQLGPRGsACVVCEDCKKNVCTKCGVETtnsrphpIWLCKICSEQREVWKRSGAWFFKGLPKQMLPQPM 94  mallard
Q6DDV6     88 GDGVNRCILCGEQLGLPGaKCVVCEDCKKNVCTKCGVQTnsr-phsIYLCKICSEQREVWKRSGAWFFKGFPKHVLPQPM 166 African clawed frog
Feature 1      
1ZBD_B    132 P 132 Norway rat
XP_691832 144 P 144 zebrafish
EOB06466   95 P 95  mallard
Q6DDV6    167 P 167 African clawed frog

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