2LNL,4ZUD,4N6H,2KS9


Conserved Protein Domain Family
7tm_1

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pfam00001: 7tm_1 (this model, PSSM-Id:278431 is obsolete and has been replaced by 394960)
Click on image for an interactive view with Cn3D
7 transmembrane receptor (rhodopsin family)
This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.
Statistics
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PSSM-Id: 278431
View PSSM: pfam00001
Aligned: 67 rows
Threshold Bit Score: 100.074
Threshold Setting Gi: 939187030
Created: 11-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2LNL_A  37 GNSLVMLVILY-SRV-GRSVTDVYLLNLALADLLFAL-T-LPIWAAsk-vNGWIF--GTFLCKVVSLLKEVNFYSGILLL 109 human
P06002  67 GNGVVIYIFAT-TKS-LRTPANLLVINLAISDFGIMItN-TPMMGInlyfETWVL--GPMMCDIYAGLGSAFGCSSIWSM 141 fruit fly
P03999  51 LNAMVLVATLR-YKK-LRQPLNYILVNVSFGGFLLCIfSvFPVFVAsc-nGYFVF--GRHVCALEGFLGTVAGLVTGWSL 125 human
P32238  58 GNTLVITVLIR-NKR-MRTVTNIFLLSLAVSDLMLCLfC-MPFNLIpnllKDFIF--GSAVCKTTTYFMGTSVSVSTFNL 132 human
P35371  64 GNAILIKVFFK-TKS-MQTVPNIFITSLALGDLLLLLtC-VPVDAThylaEGWLF--GRIGCKVLSFIRLTSVGVSVFTL 138 domestic guinea pig
Q6SW98  49 lNAIVLITQLLtNRVlGYSTPTIYMTNLYSTNFLTLTv--LPFIVLsn---qWLLpaSVASCKFLSVIYYSSCTVGFATV 123 Human herpesvirus 5 s...
P25929  57 GNLALIIIILK-QKE-MRNVTNILIVNLSFSDLLVAImC-LPFTFVytlmDHWVF--GEAMCKLNPFVQCVSITVSIFSL 131 human
P30974 100 GNGIVLWIVTG-HRS-MRTVTNYFLLNLSIADLLMSSlN-CVFNFIfmlnSDWPF--GSIYCTINNFVANVTVSTSVFTL 174 fruit fly
P30547  49 GNVVVMWIILA-HKR-MRTVTNYFLVNLAFAEASMAAfN-TVVNFTyavhNEWYY--GLFYCKFHNFFPIAAVFASIYSM 123 domestic guinea pig
P30731  88 GNVLVCHVIFK-NQR-MHSATSLFIVNLAVADIMITLlN-TPFTLVrfvnSTWVF--GKGMCHVSRFAQYCSLHVSALTL 162 house mouse
2LNL_A 110 ACISVDRYLAIVHATRTLTqkrHLV-KFV--CLGCWGLSMNLSLPFFLFRQA---------YHPNNSSPVCYEVLgnd-- 175 human
P06002 142 CMISLDRYQVIVKGMAGRPm---TIpLALgkIAYIWFMSSIWCLAPAFGWSR---------YVPEGNLTSCGIDYle--- 206 fruit fly
P03999 126 AFLAFERYIVICKPFGNFR---FSSkHALtvVLATWTIGIGVSIPPFFGWSR---------FIPEGLQCSCGPDWytv-- 191 human
P32238 133 VAISLERYGAICKPLQSRVw--QTKsHALkvIAATWCLSFTIMTPYPIYSNLvp-----ftKNNNQTANMCRFLLpn--- 202 human
P35371 139 TILSADRYKAVVKPLERQPs--NAIlKTCakAGCIWIMSMIFALPEAIFSNVhtl----rdPNKNMTSEWCAFYPvs--- 209 domestic guinea pig
Q6SW98 124 ALIAADRYRVLHKRTYARQs--YRStYII--LLLTWFAGLIFSMPAAVYTTVvihn--gtnGQSSNGHATCVLYFiad-- 195 Human herpesvirus 5 s...
P25929 132 VLIAVERHQLIINPRGWRPn--NRHaYVG--IAVIWVLAVASSLPFLIYQVMtdepfqnvtLDAYKDKYVCFDQFps--- 204 human
P30974 175 VAISFDRYIAIVHPLKRRTs--RRKvRII--LVLIWALSCVLSAPCLLYSSImt-----khYYNGKSRTVCFMMWpdgry 245 fruit fly
P30547 124 TAVAFDRYMAIIHPLQPRLs--ATAtKVV--ICVIWVLALLLAFPQGYYSTT----------ETMPGRVVCMIEWpsh-- 187 domestic guinea pig
P30731 163 TAIAVDRHQVIMHPLKPRIs--ITKgVIY--IAVIWVMATFFSLPHAICQKLft-----fkYSEDIVRSLCLPDFpep-- 231 house mouse
2LNL_A 176 -taKWRMVLRILPHTFGFIVPLFVMLFCYGFT----LR-------TLFK------------------------------- 212 human
P06002 207 -rdWNPRSYLIFYSIFVYYIPLFLICYSYWFI----IAavsahekAMREqakkmnvk----------------------- 258 fruit fly
P03999 192 gtkYRSESYTWFLFIFCFIVPLSLICFSYTQL----LR-------ALKAvaaqq-------------------------- 234 human
P32238 203 --dVMQQSWHTFLLLILFLIPGIVMMVAYGLIslelYQ-------GIKFeasqkksakerkpsttssgkyedsdgcylqk 273 human
P35371 210 -ekLLQEIHALLSFLVFYIIPLSIISVYYSLI----AR-------TLYKstlnipt------------------------ 253 domestic guinea pig
Q6SW98 196 evyTVLLSWKVLLTLVWGAAPVIMMTWFYAFF----YS-------TVQR------------------------------- 233 Human herpesvirus 5 s...
P25929 205 --dSHRLSYTTLLLVLQYFGPLCFIFICYFKIyirlKRrnnmmd------------------------------------ 246 human
P30974 246 ptsMADYAYNLIILVLTYGIPMIVMLICYSLMgrvlWGsrsige------------------------------------ 289 fruit fly
P30547 188 pdkIYEKVYHICVTVLIYFLPLLVIGYAYTVVgitlWAseipgd------------------------------------ 231 domestic guinea pig
P30731 232 -adLFWKYLDLATFILLYLLPLFIISVAYARV----AK-------KLWLcntigd------------------------- 274 house mouse
2LNL_A 213 -----------------------------AHMGQKHRA-MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQViqescerrn 262 human
P06002 259 ----------------------slrssedAEKSAEGKL-AKVALVTITLWFMAWTPYLVINCMGLFKFEGL--------- 306 fruit fly
P03999 235 -------------------------qesaTTQKAEREV-SRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHG--------- 279 human
P32238 274 trpprklelrqlstgsssranrirsnssaANLMAKKRV-IRMLIVIVVLFFLCWMPIFSANAWRAYDTASAer------r 346 human
P35371 254 ----------------------eeqsharKQVESRKRI-AKTVLVLVALFALCWLPNHLLNLYHSFTHKAYed-----ss 305 domestic guinea pig
Q6SW98 234 -----------------------------ASQKQRSRT-LTFVSVLLISFVALQTPYVSIMIFNSYATAAWpmdc-ehlt 282 Human herpesvirus 5 s...
P25929 247 -----------------------kmrdnkYRSSETKRI-NIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIat------c 296 human
P30974 290 -----------------------ntdrqmESMKSKRKV-VRMFIAIVSIFAICWLPYHLFFIYAYHNNQVAst------k 339 fruit fly
P30547 232 -----------------------ssdryhEQVSAKRKV-VKMMIVVVCTFAICWLPFHIFFLLPYINPDLYlk------k 281 domestic guinea pig
P30731 275 -----------------------vtteqyLALRRKKKTtVKMLVLVVVLFALCWFPLNCYVLLLSSKAIHT--------- 322 house mouse
2LNL_A 263 NIGRALDATEI-------LGFLHSCLNPIIY 286 human
P06002 307 --------TPLntiwgacFAKSAACYNPIVY 329 fruit fly
P03999 280 LDLRLVTIPSF-------FSKSACIYNPIIY 303 human
P32238 347 LSGTPISFILL-------LSYTSSCVNPIIY 370 human
P35371 306 AIHFIVTIFSRv------LAFSNSCVNPFAL 330 domestic guinea pig
Q6SW98 283 LRRTIGTLSRL-------VPHLHCLINPILY 306 Human herpesvirus 5 strain Merlin
P25929 297 NHNLLFLLCHL-------TAMISTCVNPIFY 320 human
P30974 340 YVQHMYLGFYW-------LAMSNAMVNPLIY 363 fruit fly
P30547 282 FIQQVYLAIMW-------LAMSSTMYNPIIY 305 domestic guinea pig
P30731 323 -NNALYFAFHW-------FAMSSTCYNPFIY 345 house mouse
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