1LKX_A 10 VPDFVLLNQITENAFIENLTMRHK-SDNIYTYIGDVVISTNPFKNLN-IYKESDIKAYNGRY------------KYEMPP 75 Dictyostelium disco... P22467 14 VEDLIMLTEVSESSLHENLKIRYK-EGLIYTSIGPVLVSMNPYKQLG-IYGNDQINLYKGKH------------EFEIPP 79 Dictyostelium disco... P34092 11 TDDLVMLPKVSEDEICENLKKRYM-NDFIYTNIGPVLISVNPFRNLN-NSGPDFIEAYRGKH------------AQEVPP 76 Dictyostelium disco... P19524 72 TEDLTSLSYLNEPAVLHAIKQRYS-QLNIYTYSGIVLIATNPFDRVDqLYTQDMIQAYAGKR------------RGELEP 138 Saccharomyces cerev... P10568 10 VEDLVLLEPLEQESLIRNLQLRYE-KKEIYTYIGNVLVSVNPYQQLP-IYDLEFVAKYRDYT------------FYELKP 75 cattle Q01989 59 HDDNCELMLLNEATFLDNLKTRYY-KDKIYTYVANILIAVNPYREIKeLYAPDTIKKYNGRS------------LGELPP 125 fruit fly 2DFS_A 71 ENDLTALSYLHEPAVLHNLKVRFIdSKLIYTYCGIVLVAINPYEQLP-IYGEDIINAYSGQN------------MGDMDP 137 chicken P32492 73 TDDLTTLSYLNEPAVLHAIKKRYM-NGQIYTYSGIVLIAANPFDKVDhLYSREMIQNYSSKR------------KDELEP 139 Saccharomyces cerev... P08964 77 VENMSELTHLNEPSVLYNLEKRYD-CDLIYTYSGLFLVAINPYHNLN-LYSEDHINLYHNKHnrlsksrldensHEKLPP 154 Saccharomyces cerev... P12844 88 TEDMANLTFLNEASVLGNLKDRYK-DLMIYTYSGLFCVVINPYKRLP-IYSESVIKHFMGKR------------RNEMPP 153 Caenorhabditis elegans
1LKX_A 76 HMYALANDAYRSMRQSQENQCVIISGESGAGKTEASKKIMQFLTFVSSNQSp---------NGERISKMLLDSNPLLEAF 146 Dictyostelium disco... P22467 80 HIYSIADKAYRALRSEGENQCIIISGESGAGKTEASKYIMQYIASITGSST----------EVERVKKTILESNPLLEAF 149 Dictyostelium disco... P34092 77 HVYQLAESAYRAMKNDQENQCVIISGESGAGKTEAAKLIMGYVSAISGSTE----------KVEYVKHVILESNPLLEAF 146 Dictyostelium disco... P19524 139 HLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSatvq---hqvEMSETEQKILATNPIMEAF 215 Saccharomyces cerev... P10568 76 HIYALANMAYQSLRDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEq--------vN--SVKEQLLQSNPVLEAF 145 cattle Q01989 126 HVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAG-------------PIETKILDANPVLEAF 192 fruit fly 2DFS_A 138 HIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSAS-----------EANVEEKVLASNPIMESI 206 chicken P32492 140 HLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNreg-----evEMSQIESQILATNPIMEAF 214 Saccharomyces cerev... P08964 155 HIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPsniapvsgssIVESFEMKILQSNPILESF 234 Saccharomyces cerev... P12844 154 HLFAVSDEAYRNMVQDKENQSMLITGESGAGKTENTKKVISYFAIVGATQAasgkeakdgkKGGTLEEQIVQTNPVLEAF 233 Caenorhabditis elegans
1LKX_A 147 GNAKTLRNDNSSRFGKYMEMQFNAVGSPIGGKITNYLLEKSRVVGRTQGERSFHIFYQMLKGLSQSKLDELGLTp-NAPA 225 Dictyostelium disco... P22467 150 GNAKTLRNNNSSRFGKYMEIQFNLGGDPEGGKITNYLLEKSRVINQTQGERNFHIFYQLLKGSSEEEKKTYNLL--SPDQ 227 Dictyostelium disco... P34092 147 GNAKTLRNNNSSRFGKYFEIQFDKAGDPVGGKIYNYLLEKSRVVYQNPGERNFHIFYQLLAGASAQEKRDYVLS--SPES 224 Dictyostelium disco... P19524 216 GNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIERNYHIFYQLMAGLPAQTKEELHLT--DASD 293 Saccharomyces cerev... P10568 146 GNAKTIRNNNSSRFGKYMDIEFDFKGFPLGGVITNYLLEKSRVVKQLEGERNFHIFYQLLAGADAQLLKALKLEr-DTGG 224 cattle Q01989 193 GNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLG--KPDD 270 fruit fly 2DFS_A 207 GNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAALPEFKTLRLG--NANY 284 chicken P32492 215 GNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQPETERNYHIFYQILEGLPEPVKQELHLS--SPKD 292 Saccharomyces cerev... P08964 235 GNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKsrNVKD 314 Saccharomyces cerev... P12844 234 GNAKTVRNNNSSRFGKFIRTHFSGSGKLAGGDIEHYLLEKSRVVRQAPGERCYHIFYQIMSGNDPSLRGKLKLSn-DITY 312 Caenorhabditis elegans
1LKX_A 226 YEYLKKSG---CFDV-------------------------STIDDSGEFKIIVKAMETLGLKESDQNSIWRILAAILHIG 277 Dictyostelium disco... P22467 228 YHYLTRNAsngCFTA-------------------------DGIDDQIGFKQTKNAMKVVGIDEPLQKEIFATLSAILLLG 282 Dictyostelium disco... P34092 225 YYYLNQSQ---CYTV-------------------------DGINDVSDYAEVRQAMDTIGLTAQEQSDIIRIVACVLHIG 276 Dictyostelium disco... P19524 294 YFYMNQGG---DTKI-------------------------NGIDDAKEYKITVDALTLVGITKETQHQIFKILAALLHIG 345 Saccharomyces cerev... P10568 225 YAYLNPD----TSRV-------------------------DGMDDDANFKVLQSAMTVIGFSDEEIRQVLEVAALVLKLG 275 cattle Q01989 271 YRYLSGCT---QYFAnakteqlipgsqksknhqqkgplkdPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLG 347 fruit fly 2DFS_A 285 FHYTKQGG---SPVI-------------------------DGIDDAKEMVNTRQACTLLGISDSYQMGIFRILAGILHLG 336 chicken P32492 293 YHYTNQGG---QPNI-------------------------AGIDEAREYKITTDALSLVGINHETQLGIFKILAGLLHIG 344 Saccharomyces cerev... P08964 315 YKILSNSN---QDII-------------------------PGINDVENFKELLSALNIIGFSKDQIRWIFQVVAIILLIG 366 Saccharomyces cerev... P12844 313 YHFCSQ-A---ELTI-------------------------EGMDDKEEMRLTQEAFDIMGFEDNETMDLYRSTAGIMHMG 363 Caenorhabditis elegans
1LKX_A 278 NITFAEAA--EQRtGtttvKVSDTKS-LAAAASCLKTDQQSLSIALCYRSISTGvg----krCSVISVPMDCNQAAYSRD 350 Dictyostelium disco... P22467 283 NLSFNKSA--SGNgS----VISDKKL-ANTIASLMGVDAIVLESSLVSRQISTGqg----arISTYSVPQTVEQAMYARD 351 Dictyostelium disco... P34092 277 NIYFIEDD--KGNaA----IYDPNA--LELAASMLCIDSATLQNAILFRVINTGgaggagnrRSTYNVPQNVEQANGTRD 348 Dictyostelium disco... P19524 346 NIEIKKTR--NDA-S----LSADEPN-LKLACELLGIDAYNFAKWVTKKQIITR--------SEKIVSNLNYSQALVAKD 409 Saccharomyces cerev... P10568 276 NVELINEFqaNGVpA----SGIRDGRgVQEIGELVGLNSVELERALCSRTMETA--------KEKVVTTLNVIQAQYARD 343 cattle Q01989 348 NIAFEEIP--DDVrGgc-qVSEASEQsLTITSGLLGVDQTELRTALVSRVMQSKggg---fkGTVIMVPLKIYEASNARD 421 fruit fly 2DFS_A 337 NVEFASRD--SDScA----IPPKHDP-LTIFCDLMGVDYEEMAHWLCHRKLATA--------TETYIKPISKLHAINARD 401 chicken P32492 345 NIEMKMTR--NDA-S----LSSEEQN-LQIACELLGIDPFNFAKWIVKKQIVTR--------SEKIVTNLNYNQALIARD 408 Saccharomyces cerev... P08964 367 NIEFVSDR--AEq-A----SFKND---VSAICSNLGVDEKDFQTAILRPRSKAG--------KEWVSQSKNSQQAKFILN 428 Saccharomyces cerev... P12844 364 EMKFKQRP--REEqA----EPDGEED-ALNAAAMLGIQAEEFLKALTKPRVRVG--------TEWVNKGQNLEQVNWAVS 428 Caenorhabditis elegans
1LKX_A 351 ALAKALYERLFNWLVSKINTIINCTTe-----KGPVIGILDIYGFEVFQNNSFEQLNINFCNEKLQQLFIELTLKSEQEE 425 Dictyostelium disco... P22467 352 AFAKATYSKLFDFIVRKINQSIEVKT------IGKVIGVLDIYGFEIFENNSFEQFCINYVNETLQQIFIDLTLKTEQEE 425 Dictyostelium disco... P34092 349 ALARTIYDRMFSWLVERVNQSLSYYKs----pYQNVIGILDIFGFEIFEKNGFEQFCINFVNEKLQQFFIELTLKAEQEE 424 Dictyostelium disco... P19524 410 SVAKFIYSALFDWLVENINTVLCNPAvn--dqISSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEE 487 Saccharomyces cerev... P10568 344 ALAKNIYSRLFNWLVNRINESIKVGTg----eKRKVMGVLDIYGFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEE 419 cattle Q01989 422 ALAKAIYSRLFDRIVGLINQSIPFQA------SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQEL 495 fruit fly 2DFS_A 402 ALAKHIYANLFNWIVDHVNKALHSTVk-----QHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEE 476 chicken P32492 409 SVAKFIYSTLFDWLVDNINKTLYDPEldqqdhVFSFIGILDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEE 488 Saccharomyces cerev... P08964 429 ALSRNLYERLFGYIVDMINKNLDHGSa-----TLNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSE 503 Saccharomyces cerev... P12844 429 GLAKAIYARMFKWIITRCNKTLDAKEi----eRKHFIGVLDIAGFEIFDLNSFEQLWINFVNERLQQFFNHHMFVLEQEE 504 Caenorhabditis elegans
1LKX_A 426 YVREGIEWKNIEYf-NNKPICELIEKk--pIGLISLLDEACLIAKS----TDQTFLDSICKQF-EKNP---HLQSY-Vvs 493 Dictyostelium disco... P22467 426 YVQEGITWIPVQYi-NNKACVDLIEKk--pIGILSLLDEECLFPEG----NDQTMIDKLNKHF-SNHT---HYSKV-Er- 492 Dictyostelium disco... P34092 425 YVREGIKWEPIKYf-NNQIVCDLIEGks-pPGIFSLLDDICSTLHAqstgTDQKFLEKMAGIY-DGHL---HWr------ 492 Dictyostelium disco... P19524 488 YVKEEIEWSFIEFn-DNQPCIDLIENk---LGILSLLDEESRLPAG----SDESWTQKLYQTL-DKSPtnkVFSKP-R-- 555 Saccharomyces cerev... P10568 420 YKREGIPWVKVEYf-DNGIICNLIEHn--qRGILAMLDEECLRPGVv---SDSTFLAKLNQLF-SKHS---HYESKvTqn 489 cattle Q01989 496 YKREGLNVPEITFt-DNQDIIELIEAk--sNGIFTLLDEESKLPKP----SYSHFTAEVHKSW-ANHYr-lGLPRSsRlk 566 fruit fly 2DFS_A 477 YMKEQIPWTLIDFy-DNQPCINLIEAk---MGVLDLLDEECKMPKG----SDDTWAQKLYNTHlNKCA---LFEKP-R-- 542 chicken P32492 489 YVKEEIEWSFIEFs-DNQPCIDLIENk---LGILSLLDEESRLPSG----SDESWASKLYSAF-NKPPsneVFSKP-R-- 556 Saccharomyces cerev... P08964 504 YLKENIQWDYIDYgkDLQLTIDLIESkgppTGVLPLLDEEAVLPKS----TDESFYSKLISTWdQNSS---KFKRS-Rl- 574 Saccharomyces cerev... P12844 505 YKREGIAWTFIDFglDLQACIELIEKp---LGIISILDEECIVPKA----TDMTYAQKLLDQHlGKHP---NFQKP-Kpp 573 Caenorhabditis elegans
1LKX_A 494 k----drsIGDTCFRLKHYAGDVTYDVRGFLDKNKDTLFGDLISSMQSSSD-PLVQGLFPP------------------- 549 Dictyostelium disco... P22467 493 --------QKNSQFIINHYAGKVFYNIDGFLDKNRDTLFNDLVTLATSSSC-SLLVEIFKYvpplevdpeqekknrdkfs 563 Dictyostelium disco... P34092 493 --------GMTGAFAIKHYAGEVTYEAEGFSDKNKDTLFFDLIEAIQCSKM-PFLASLFNEd------------------ 545 Dictyostelium disco... P19524 556 --------FGQTKFIVSHYALDVAYDVEGFIEKNRDTVSDGHLEVLKASTN-ETLINILEGlekaakkleea-------k 619 Saccharomyces cerev... P10568 490 aqrqydhsMGLSCFRICHYAGKVTYNVNSFIDKNNDLLFRDLSQAMWKARH-PLLRSLFPEg------------------ 550 cattle Q01989 567 ah---rtlRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDN-PLLQTLFPSgs----------------- 625 fruit fly 2DFS_A 543 --------LSNKAFIIKHFADKVEYQCEGFLEKNKDTVYEEQIKVLKSSKKfKLLPELFQDeekaisptsatpsg-rvpl 613 chicken P32492 557 --------FGQTKFIVSHYAVDVEYEVEGFIEKNRDSVSLGHLDVFKATTN-PIFKQILDNrelrsddap---------- 617 Saccharomyces cerev... P08964 575 ----------KNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQN-DIISKLFQPegeksssag---------- 633 Saccharomyces cerev... P12844 574 k-----gkQGDAHFAIVHYAGTVRYNATNFLEKNKDPLNDTAVALLKHSTDnSLMLDIWQDyqtqeeaae---------- 638 Caenorhabditis elegans
1LKX_A 550 ----------TRPEDSKKRP-ETAGSQFRNAMNALITTLLACSPHYVRCIKSNDNKQAGVIDEDRVRHQVRYLGLLENVR 618 Dictyostelium disco... P22467 564 kngfannaakTFIPTDKKRP-ITAGFQFKNQVTSLLKSLYSCSPHYVRCIKPNSNMRALEWDQSKCAEQVAYLGLFENLL 642 Dictyostelium disco... P34092 546 -----------tGSLQKKRP-TTAGFKIKTSAGELMKALSQCTPHYIRCIKPNETKKAKDWENSRVKHQVQYLGLLENVR 613 Dictyostelium disco... P19524 620 kleleqagskKPGPIRTVNRkPTLGSMFKQSLIELMNTINSTNVHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETIR 699 Saccharomyces cerev... P10568 551 ----------DPKQASLKRP-PTAGAQFKSSVTTLMKNLYSKNPNYIRCIKPNEHQQRGHFSFELVSVQAQYLGLLENVR 619 cattle Q01989 626 ---------sTSVRGKL-NF-ISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLE 694 fruit fly 2DFS_A 614 srtpvkpakaRPGQTSKEHK-KTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIR 692 chicken P32492 618 -eeqntekkiMIPARLSQKK-PTLGSMFKKSLGELMAIINSTNVHYIRCIKPNSEKKPWEFDNLMVLSQLRACGVLETIR 695 Saccharomyces cerev... P08964 634 -veanisnqeVKKSARTSTF-KTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIR 711 Saccharomyces cerev... P12844 639 --aakagqtaGGKRGKSSSF-ATVSMIYRESLNNLMNMLYQTHPHFIRCIIPNEKKASGVIDSALVLNQLTCNGVLEGIR 715 Caenorhabditis elegans
1LKX_A 619 VRRAGFAGRIEYTRFYNRYKMLCKKTW--------PSFNGTAKQATELILQQH----NID---KEEIRMGKTKVFIR 680 Dictyostelium discoideum P22467 643 VRRAGYCYRQTFSKFMRRYYMIGKSTW--------PKWSGDAEKGVNLLMGEL----TQEiniKEEVQYGKTKIFIR 707 Dictyostelium discoideum P34092 614 VRRAGFAYRNTFDKVLKRYKKLSSKTWgi-----wGEWKGDAIEGCKTIFQDM----NLE---AGQWQLGKTKVFIR 678 Dictyostelium discoideum P19524 700 ISCAGFPSRWTFEEFVLRYYILIPHEQwdlifkkkETTEEDIISVVKMILDAT----VKD---KSKYQIGNTKIFFK 769 Saccharomyces cerevisi... P10568 620 VRRAGYAYRQAYGSFLERYRLLSRSTW--------PRWNGGDQEGVEKVLGEL----SMS---SEELAFGKTKIFIR 681 cattle Q01989 695 LMEHGYPSRVLFADLYSMYKSVLPPELvs----------lPARTFCEAMFQSL----NLS---AKDFKFGITKVFFR 754 fruit fly 2DFS_A 693 ISAAGFPSRWTYQEFFSRYRVLMKQKd----------vLSDRKQTCKNVLEKL----ILD---KDKYQFGKTKIFFR 752 chicken P32492 696 ISCAGFPSRWTFDEFVQRYFLLTDYSLwsgilynpDLPKEAIVNFCQSILDAT----ISD---SAKYQIGNTKIFFK 765 Saccharomyces cerevisi... P08964 712 LAREGYPNRIAFQEFFQRYRILYPENSttt--tfsSKLKASTKQNCEFLLTSL----QLD---TKVYKIGNTKLFFK 779 Saccharomyces cerevisi... P12844 716 ICRKGFPNRMLYPDFKHRYAILAADAAke----------sDPKKASVGILDKIsvdgNLT---DEEFKVGETKIFFK 779 Caenorhabditis elegans
Jiyao W et al.(2023). "The conserved domain database in 2023.",