2K3S,1WYQ,1SJJ,2DK9,2E9K,2D88,2D89,1WYO,1WYM,1H67,1WYN,3I6X,1WYR,2D86,1RT8,1PXY,1RT8,2EYI,1PXY


Conserved Protein Domain Family
CH

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pfam00307: CH (this model, PSSM-Id:278723 is obsolete and has been replaced by 333996)
Click on image for an interactive view with Cn3D
Calponin homology (CH) domain
The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.
Statistics
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PSSM-Id: 278723
View PSSM: pfam00307
Aligned: 131 rows
Threshold Bit Score: 39.2368
Threshold Setting Gi: 20138865
Created: 11-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2K3S_A   4 GSKNMLLEWCRamtrnyehvDI-------QNF--SSSWSSGMAFCALIHK-FfPEAFdyaeldpakRR------------ 61  house mouse
Q9W2W2  19 WSRGDILDWFNet--------------lqCNLinIEQLCTGAAYCNLMHMlY-PKLI---------NLkrvkffs----n 70  fruit fly
O97251  19 VSRKELIEWVNry--------------lkLNItkVEQCSNGAIYIQLLDIlF-PNKS---------VLhkakwna----k 70  Plasmodium falciparum...
1WYO_A  22 LSRHDMLAWVNds--------------lhLNYtkIEQLCSGAAYCQFMDMlF-PGCV---------HLrkvkfqa----k 73  human
O75427 535 PDEKDLMTQLRqvlesrlqrPLp------EDL--AEALASGVILCQLANQlR-PRSV---------PFihvpspavpkls 596 human
P41737 132 REEKELVEHLResiemrlkvSLh------EDL--GAALMDGVVLCHLVNHiR-PRSV---------ASihvpspavpkls 193 domestic cat
Q9NHV9  19 DLWRECVAWLTrckvippdhKAaqpdaeiRIL--AMTLRDGVLLCNLVIHlD-PSSL---------DPrefnrkpq--ma 84  fruit fly
P52735   2 EQWRQCGRWLIdckvlppnhRVvwpsavvFDL--AQALRDGVLLCQLLHNlS-PGSI---------DLkdinfrpq--ms 67  human
P15498   2 ELWRQCTHWLIqcrvlppshRVtwdgaqvCEL--AQALRDGVLLCQLLNNlL-PHAI---------NLrevnlrpq--ms 67  human
2D86_A   9 EPWKQCAQWLIhckvlptnhRVtwdsaqvFDL--AQTLRDGVLLCQLLNNlR-AHSI---------NLkeinlrpq--ms 74  human
2K3S_A  62 -----HNFTLAFSTAEkLADCA--QLLEVDDMVRlaVPDSKCVYTYIQEL 104 house mouse
Q9W2W2  71 qeyeyVNNFKELQKAFnKVNVS--LPAEVNDLIKghRVENFKFAVWFRHF 118 fruit fly
O97251  71 meyecIINYKLIQSVFnKLGIK--KYMDVDKLIKgkYQDNFEFLQWFKSF 118 Plasmodium falciparum 3D7
1WYO_A  74 leheyIHNFKVLQAAFkKMGVD--KIIPVEKLVKgkFQDNFEFIQWFKKF 121 human
O75427 597 alkarKNVESFLE-ACrKMGVPeaDLCSPSDLLQ-------GTARGLRTA 638 human
P41737 194 makcrRNVENFLE-ACrKLGVPeeKLCLPHHILE--EKGLVKVGITVQAL 240 domestic cat
Q9NHV9  85 qflcsKNIKLFLDVCHnNFGIRdaDLFEPTMLYD--LTNFHRVLITLSKL 132 fruit fly
P52735  68 qflclKNIRTFLKVCHdKFGLRnsELFDPFDLFD--VRDFGKVISAVSRL 115 human
P15498  68 qflclKNIRTFLSTCCeKFGLKrsELFEAFDLFD--VQDFGKVIYTLSAL 115 human
2D86_A  75 qflclKNIRTFLTACCeTFGMRksELFEAFDLFD--VRDFGKVIETLSRL 122 human
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