Conserved Protein Domain Family
GP120

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pfam00516: GP120 
Envelope glycoprotein GP120
The entry of HIV requires interaction of viral GP120 with CD4 and a chemokine receptor on the cell surface.
Statistics
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PSSM-Id: 278917
View PSSM: pfam00516
Aligned: 2 rows
Threshold Bit Score: 887.202
Threshold Setting Gi: 6015102
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P18094  24 QYVTVFYGIPAWKNASIPLFCA-------TKNRDTWGTIQCLPDNDDYQEIIL-NVTEAFDAWNNTVTEQAVEDVWHLFE 95  Human immunodeficienc...
P04578  34 LWVTVYYGVPVWKEATTTLFCAsdakaydTEVHNVWATHACVPTDPNPQEVVLvNVTENFNMWKNDMVEQMHEDIISLWD 113 HIV-1 M:B_HXB2R
P18094  96 TSIKPCVKLTPLCVAMNCSRVQGNTTTpnprtsssttsrpPTSAASIINETSncienntcaglgyeEMMQCEFNMK-GLE 174 Human immunodeficienc...
P04578 114 QSLKPCVKLTPLCVSLKCTDLKNDTNT-------------NSSSGRMIMEKG--------------EIKNCSFNIStSIR 166 HIV-1 M:B_HXB2R
P18094 175 QDKKRRYKDTWYLEDVVCDNTTagTCY-MRHCNTSIIKESCDKHYWDAMRFRYCAPPGFALLRCNDTNYSGFEPkCTKVV 253 Human immunodeficienc...
P04578 167 GKVQKEYAFFYKLDIIPIDNDT--TSYkLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGP-CTNVS 243 HIV-1 M:B_HXB2R
P18094 254 AASCTRMMETQTSTWFGFNGTRAENRTYIywhgR-----DN-RTII-SLNKyyNLTMRCKRPGNKTVLPITLMSG----L 322 Human immunodeficienc...
P04578 244 TVQCTHGIRPVVSTQLLLNGSLAEEEVVI----RsvnftDNaKTIIvQLNT--SVEINCTRPNNNTRKRIRIQRGpgraF 317 HIV-1 M:B_HXB2R
P18094 323 VFHSQPINTrpRQAWCRFG-GRWREAMQEVKQTLVQHprykgINDTGKINFtKPGAGSDPEVAFMWTNCRGEFLYCNMTW 401 Human immunodeficienc...
P04578 318 VTIGKIGNM--RQAHCNISrAKWNNTLKQIASKLREQ-----FGNNKTIIF-KQSSGGDPEIVTHSFNCGGEFFYCNSTQ 389 HIV-1 M:B_HXB2R
P18094 402 FLN-------W-VEDKNQTRRN-----YCHIKQIINTWHKVGKNVYLPPREGELACESTVTSIIANIDIDKNRTHTNItF 468 Human immunodeficienc...
P04578 390 LFNstwfnstWsTEGSNNTEGSdtitlPCRIKQIINMWQKVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEI-F 468 HIV-1 M:B_HXB2R
P18094 469 ---SAEVAELYRLELGDYKLIEITPIGFAPTDQRRysSTPVRNKR 510 Human immunodeficiency virus type 2 (ISOLATE BEN)
P04578 469 rpgGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKR--RVVQREKR 511 HIV-1 M:B_HXB2R
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