3J9P


Conserved Protein Domain Family
Ion_trans

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pfam00520: Ion_trans (this model, PSSM-Id:278921 is obsolete and has been replaced by 395416)
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Ion transport protein
This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Statistics
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PSSM-Id: 278921
View PSSM: pfam00520
Aligned: 244 rows
Threshold Bit Score: 40.3264
Threshold Setting Gi: 81891851
Created: 12-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3J9P_D    1153 MAFnstgIIne-------------------------tsDhseILDTTNSYLIKTCMILVFLSSIFgyckeagqifqqkrN 1207
O76266     227 FCVetleRFakshcva---------------deapnflDpffIIETICTAWFTFEAIVRFISCPNk------------iM 279  medicinal leech
Q25376     187 FCLetlpEFkryellndti---------ivddampkfgTpffIIETGCIIWFTMELLIRFASCPGk------------lD 245  Doryteuthis opal...
P08510     244 FCLetlpEFkhykvfntttng-----tkieedevpditDpffLIETLCIIWFTFELTVRFLACPNk------------lN 306  fruit fly
Q26095     199 FCLetipSLnpdkpe------------------gshmrVtwfIINTICNSWFTLEYLLRLIASPNk------------lQ 248  penicillate jell...
Q26094     191 FVIetlpVFapkelltnngt--------iyktvysehaTwmfTVNTAVICWFTIEFILRLICCPNk------------iK 250  penicillate jell...
G5EFC3     221 FCLkthqSFrlpvligqnitmpggvvqpsiervsteplPifgQIEMLCNIWFTLELIIRFVFCPSk------------iR 288  Caenorhabditis e...
O76457     191 FCLkthpEMrvpvlknatsrtvngtytwrlekketephEaffYIECASNAWFTFEIIIRFVVAPNk------------lD 258  California sea hare
Q9XXD1     247 LVLgslpELqvatkqrnnlt--------geeftemepmPilgYIEYVCIVWFTMEYGLKMLVSAEr------------sK 306  Caenorhabditis e...
NP_722937  191 FCLkthpDMrvpivrnitvktangsngwfldktqtnahIaffYIECVCNAWFTFEILVRFISSPNk------------wE 258  fruit fly
3J9P_D    1208 YFMDISNVLEWIIyttgiifVLPLFVEIpahl----------------qwqCGA-------IAV--YFYWMNFLLYLQRF 1262
O76266     280 FWFGFQNLIDVTA-------VVPYYVTLfnvvstm---------scstaksSAS-------LAFlrVIRLVRVFKLTKHS 336  medicinal leech
Q25376     246 FFKDSMNAIDVVS-------IMPYFITLgtviqndtn------tqdkqnmsLAI-------LRVirLVRVFRIFKLSRHS 305  Doryteuthis opal...
P08510     307 FCRDVMNVIDIIA-------IIPYFITLatvvaeeedtlnlpkapvspqdkSSNqamslaiLRVirLVRVFRIFKLSRHS 379  fruit fly
Q26095     249 FVKSTLNIVDLVS-------IIPYYVTAtvgen--------------dsgsIAV-------LRVvrVIRVIRIFKLTRHS 300  penicillate jell...
Q26094     251 FFLNTGNIIDFLS-------ILPYYLSLvlv-----------------sssKGS-------FSMlrVIRVLRVFKLSRHS 299  penicillate jell...
G5EFC3     289 FFKSPLNMIDLVA-------TLSFYADAmmvrv-------------vedepKDV-------VEFlsMIRIFRLFKLTQHH 341  Caenorhabditis e...
O76457     259 FLKAPVNIIDIVA-------TLSFYLDFmlte---------------lkqeSDM-------LEFfsIIRIMRLCKLTRHS 309  California sea hare
Q9XXD1     307 TFRQLLNIIDLLA-------ILPFIIEMlllifgist-----eqlrdlkgaFLV-------IRIlrVLRVIRVLKLGRYS 367  Caenorhabditis e...
NP_722937  259 FIKSSVNIIDYIA-------TLSFYIDLvlqrfa------------shlenADI-------LEFfsIIRIMRLFKLTRHS 312  fruit fly
3J9P_D    1263 ENCGIFIVmLEVILKTLLRSTVVFIFLLLAFGLSF-YILL-N--LQDP---FSSPLLSIIQTFSMMLGdINYRESFLEPY 1335
O76266     337 TGLQVLILtIKASSEELGLFLVVLLVCMLVYSSAI-YYAElgvp----ksnIHSIPDAFWWAIITMTT-VGYGDTFPVGP 410  medicinal leech
Q25376     306 KGLQILGQtLKASLRELGLLIFFLVIGVVLFSSAV---YFaE--VDTEqshFKSIPDSFWWAVVTMTT-VGYGDMSPVGV 379  Doryteuthis opal...
P08510     380 KGLQILGRtLKASMRELGLLIFFLFIGVVLFSSAV---YFaE--AGSEnsfFKSIPDAFWWAVVTMTT-VGYGDMTPVGV 453  fruit fly
Q26095     301 RGLHILANtISASLHELCMLVLFLAIGVVLFSSAA---YYaE--SANSqtgFKSIPHGFWWAVVTMTT-VGYGDLFPSTY 374  penicillate jell...
Q26094     300 RGLQILGNtLKASFNELMMLAFFLFVMILIFGSCVyYAEY-----KEPgtkFISIPSSFWWAIVTMTT-VGYGDMHPVTF 373  penicillate jell...
G5EFC3     342 QGLQILIHtFRASAKELILLVFFLILGIVIFAALV---YYaekmeANPnnqFQSIPLGLWWAICTMTT-VGYGDMTPHTS 417  Caenorhabditis e...
O76457     310 AGLKILIHtFKASAKELILLIFFLVLGIVIFAALI---YYaeriqYNPendFESIPVGLWWAIVTMTT-VGYGDMAPKTY 385  California sea hare
Q9XXD1     368 SGLQMFGKtLKASFRQLGMMAMVVMTGVIFFSTLV-YFLE----KDEPaskFHSIPAACWWCIVTMTT-VGYGDLTPVTV 441  Caenorhabditis e...
NP_722937  313 SGLKILIQtFRASAKELTLLVFFLVLGIVIFASLV---YYaeriqPNPhndFNSIPLGLWWALVTMTT-VGYGDMAPKTY 388  fruit fly
3J9P_D    1336 LRNelahpvlsfaQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHAS 1381
O76266     411 FGK----------VIGAACAISGVLTLAMPVPILTGHFNKFYAHKT 446  medicinal leech
Q25376     380 YGK----------LVGSLCAIAGVLTIALPVPVIVSNFNYFYHRDA 415  Doryteuthis opalescens
P08510     454 WGK----------IVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET 489  fruit fly
Q26095     375 FGK----------MVGALCAISGVLVIALPVPVIVSNFEYYYKEEQ 410  penicillate jellyfish
Q26094     374 WGQ----------IVGSMAVVCGVLTIALPVPVVVSNFEYFYTKER 409  penicillate jellyfish
G5EFC3     418 FGR----------LVGSLCAVMGVLTIALPVPVIVSNFAMFYSHNQ 453  Caenorhabditis elegans
O76457     386 VGM----------FVGALCALAGVLCIALPVPVIVSNFALFYSHTQ 421  California sea hare
Q9XXD1     442 PGK----------LVATGAIACGVLVLALPITIIVDNFMKVAETER 477  Caenorhabditis elegans
NP_722937  389 IGM----------FVGALCALAGVLTIALPVPVIVSNFAMYYSHTQ 424  fruit fly
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