3HZJ


Conserved Protein Domain Family
RabGAP-TBC

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pfam00566: RabGAP-TBC (this model, PSSM-Id:278964 is obsolete and has been replaced by 366170)
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Rab-GTPase-TBC domain
Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Statistics
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PSSM-Id: 278964
View PSSM: pfam00566
Aligned: 78 rows
Threshold Bit Score: 72.2938
Threshold Setting Gi: 74616670
Created: 14-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3HZJ_A         36 EALRAEVWQllagchdnqaxld-------------------------ryrilitkdsaqeSVITRDIHRTFPa----hDY 86   human
O94661         38 KSLRKSVWVslcglscrhrmec-------------------------lsrstsqssyadqNQVHLDSERSFFqy--klNP 90   Schizosacchar...
Q7S8L1         61 DELRQQAWPillglppkpfdedsss--------------------ssyssweslpphqdeDQVQLDVDRSFTyypshtSD 120  Neurospora cr...
Q6CII2         36 QRTRSHVWSilsraslekctqey-----------------------lrlvqlgappsnwiSKIKNDTFRTLSt----dEK 88   Kluyveromyces...
Q7Q4I8        212 PSLRRVVWKhilnvypdgmtgrermeymkrksae-yfrlrdvwrstmqrgnivgelayvtSMVRKDVLRTDRlhp-fyAG 289  Anopheles gam...
Q6BQX2        139 FQLRSTIWKklflisqgnvipetsr--------------------lvfdnfqhsysleisKQISKDLSRTFPl----vEF 194  Debaryomyces ...
BAE00843      103 HALRKQAWKfllgyfpwdstkeertqlqkqktdeyfrmklqwksvsqeqekrnsrlrdyrSLIEKDVNRTDRt----nKF 178  crab-eating m...
XP_001309419  244 TDLRPLLWPqllgvlpfakeiesvldqrvdeyk---lvkyqwesmssfqlthrpelrsayQTIRMDVKRTHLp-----EG 315  Trichomonas v...
XP_001307913  123 EESRWFVWLyllgiydpnksydeniasitnnnyiyesirkswnnipkiqmnetssisklaNDVMKDVKRTDRnl--eqFS 200  Trichomonas v...
NP_001079950  389 pSLRGEVWPfllgyypwettsedrealrvhrree--ysqiqkkrvsmsptaqkdfwrnvqFIVDKDVVRTDRsn--qfFR 464  African clawe...
3HZJ_A         87 F--KDtgGDGQESLYKICKAYSVYDE---DIG-------YCQGQSFLAAVLL--------------L-HXPEEQ------ 133  human
O94661         91 F--LL--RKHRSQLTKLLSVVFKHYP---ELC-------YYQGLHDIAQILLl---------------TLPFSH------ 135  Schizosacchar...
Q7S8L1        121 S--AR--SLQKSLLSSLILSVLRRHP---YLH-------YFQGYHDISQVLLl---------------VLPAHL------ 165  Neurospora cr...
Q6CII2         89 F--RN--KVTESQLIRVLSCFAWDVLdsnQTHelpglspYVQGMNVLLAPFLy---------------VCPTEPi----- 144  Kluyveromyces...
Q7Q4I8        290 S--DD--NQNIAALFNVLTTYALNHP---AVS-------YCQGMSDIASPLL--------------VtMGDEAQ------ 335  Anopheles gam...
Q6BQX2        195 F--KN--EETINNLSTILNVYANYDV---ELG-------YCQGLLFLVGVLYy-------------HfKSDSTL------ 241  Debaryomyces ...
BAE00843      179 YegQD--NPGLILLHDILMTYCMYDF---DLG-------YVQGMSDLLSPLL--------------YvMENEVD------ 226  crab-eating m...
XP_001309419  316 S--NE--QAIKPMMENILKTYAIWNY---DVR-------YTQGINDVVLPFLl------------vFyNSKLYTddqvea 369  Trichomonas v...
XP_001307913  201 R--DD--HPNLSVLNNVLVSYAMYCK---DTG-------FVQGMGDIVSLFIilyikswdnektcnLvDGRKVDketaen 266  Trichomonas v...
NP_001079950  465 G--ED--NPNVESMRRILLNYAVYSP---GVG-------YSQGMSDLVAPIL--------------AeVLDESD------ 510  African clawe...
3HZJ_A        134 -AFCVLVKIXy-dYGLRDLYRNNFED--LHCKFY---QLERLXQEQLPDLHSHFSDl---NLEAHX-YASQWFLTLFT-A 201  human
O94661        136 -ALPLMEHLVf--YRLRDFMLPT-----LDGTVKqlqLILAVIKARDPTLYEYLi-----KADIQCyFALSWLITWFA-H 201  Schizosacchar...
Q7S8L1        166 -RSPALARLSa--LRIRDFMLPN-----LQAAIAqlrLIPDILRVSDPPLWRHL-------SGTEPfFALSGTITMYA-H 229  Neurospora cr...
Q6CII2        145 -AYKLFHSLCf--QMIPTYLNQSLSGvhVAAK-----LLDKCLKIIDPKLSKFLTDn---LLTAEI-FGIPSILTLSA-C 211  Kluyveromyces...
Q7Q4I8        336 -AYICFCAIM---ERLSCNFML--DGiaMTLKFA---HLSEALQYYDPDFFAYLKHh---QADDLL-FCYRWLLLEMK-R 401  Anopheles gam...
Q6BQX2        242 -TFHALVTIMesePELHDIFTSTTMSytLNKWKF---EFSAILREIDNELYEHLNK----FVDMQV-FLYQWWLSFISsH 312  Debaryomyces ...
BAE00843      227 -AFWCFASYMd---QMHQNFEEQMQG--MKTQLI---QLSTLLRLLDSGFCSYLESq---DSGYLY-FCFRWLLIRFK-R 292  crab-eating m...
XP_001309419  370 lGFWCFASFA---EKINSSLIEGSMDgvTNIDLQ---LVIELLGTHDPKVKEWIIKs---DMQDMN-FVVSSFMLAFK-R 438  Trichomonas v...
XP_001307913  267 fIFQILCKMMt--ITQQDRMFTDL----LKQQEFafeRVFDIIKDFHPNLAEWLQNn---QLQNLI-FLYRHIILLFK-R 335  Trichomonas v...
NP_001079950  511 -TFWCFVGLM-----QNTIFISSPCDedMEKQLM---YLRELLRLVHPHFHQHLLSldedGL-QML-FCHRWILLCFK-R 578  African clawe...
3HZJ_A        202 KFPL-CXVFHIID-LLLCe--gLNiIFH-VALA-LL-KTSKEDLL 239  human
O94661        202 DVSDiSVVCRLFD-FFIs----SHpLTV-VYTCaQVvLDNRTSII 240  Schizosaccharomyces pombe 972h-
Q7S8L1        230 DITTlGEITRLFD-VLLa----REpVFS-VYMFaAIvRSRREELF 268  Neurospora crassa
Q6CII2        212 NKPL-DQVIKLWD-FMFay-gfHMnILF-IVAQlVI---NRQAIM 249  Kluyveromyces lactis
Q7Q4I8        402 EFAF-DDALRMLE-VLW------------SSLPpMApKGE--LAL 430  Anopheles gambiae str. PEST
Q6BQX2        313 TPDL-SIVNRVMDfCLLQg--wKTgMFK-ISLG-LL-LVNKPILM 351  Debaryomyces hansenii
BAE00843      293 EFSF-LDILRLWE-VMWTelpcKNfHLL-LCCA-IL-ESEKQQIM 332  crab-eating macaque
XP_001309419  439 SLDE-PNLERAWD-SAMcsdspHTfIIC-FCAAlII-FCY--PAF 477  Trichomonas vaginalis G3
XP_001307913  336 EFKL-ESVLRLWD-AIFsh-ekPFvFIRyFCAA-ILiNSFPQLIV 376  Trichomonas vaginalis G3
NP_001079950  579 EFPD-SEALRMWEaCWAHyq-tDYfHLF-LCVA-II-FLYgddvi 618  African clawed frog
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