1KFX


Conserved Protein Domain Family
Calpain_III

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pfam01067: Calpain_III (this model, PSSM-Id:279416 is obsolete and has been replaced by 395848)
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Calpain large subunit, domain III
The function of the domain III and I are currently unknown. Domain II is a cysteine protease and domain IV is a calcium binding domain. Calpains are believed to participate in intracellular signaling pathways mediated by calcium ions.
Statistics
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PSSM-Id: 279416
View PSSM: pfam01067
Aligned: 164 rows
Threshold Bit Score: 90.2933
Threshold Setting Gi: 290985465
Created: 7-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KFX_L       355 WKLTKMDGNWRRGS---------------------------------------------------TAGGCrNYPNTFWMN 383 human
XP_001626960 357 WHIYKHNYNWTQGQ---------------------------------------------------NAGGCvQNQDTFLKN 385 starlet sea ane...
XP_011440450 357 WHEGLSHGAWKSPG---------------------------------------------------RAGGCiNHKTTFASN 385 Pacific oyster
XP_002428101 357 WRESWVKGSWTIGHkgs---------------------------------------------lsdRSGGGnVDSETFLRN 391 human body louse
CCD74722     389 WRLCEHHGAWCGHQ---------------------------------------------------T-GGNlQYRNTFLHN 416 Schistosoma man...
XP_005804850 355 WRETQSYGEWAPSPdalgtaplstgkysssaqalsnirpegkkvressqegtkrgavieemdrrsRCGGCiNHRDSFLHN 434 southern platyfish
XP_011605051 347 hgEEHLYGEWASAPsfqggsqdrttkq--------------------------aggceaevdkrsRCGGCiNHRDTFLHN 400 torafugu
XP_009301387 316 paqrrdkkeqrlserqregriqgekltkidnaeikpkqikdrkecvkeleggmemrwdmqidrrtRCGGCiNHRDTFLHN 395 zebrafish
XP_011410135 350 WHDATFHGEWKEKT----------------------------------------------------AGGCfNHPDTFTNN 377 Amphimedon quee...
XP_002107604 355 WKESTFHGCWSTSAn--------------------------------------------------RAGGCiNNRATFLQN 384 Trichoplax adha...
1KFX_L       384 PQYLIKLeeEDEDEEDgesGCTFLVGLIQK----HRRRQ----------RKM----GE---DMHTIGFGIYEvpEELsgq 442 human
XP_001626960 386 PQYAFSItdNEGED--------AMVSLMQE----DRRKD----------KSK----GV---GNLTIGFYIMKv--EE--- 431 starlet sea ane...
XP_011440450 386 PQFIFDIteSEDDP---------MFHLLQK----STRSA------------A----GK---ENDTIGFSIFKv--EK--- 428 Pacific oyster
XP_002428101 392 PQYLFEI-------ESe--EDEVTVQVLQW----DGVEPstpinetevvRPR----HR---TLL-IGFSILRv--ET--- 445 human body louse
CCD74722     417 PQYYFDIm-------Nd--SDEVLLSLVRK----YNRDP----------LTMviepDL---NPLSIGLGLFKi--EN--- 465 Schistosoma man...
XP_005804850 435 PQYMFEVqs---------kEEEVLICLQQEdrrvLKKN------------GG----GE---N-LPIGFEVLK--VEA--- 480 southern platyfish
XP_011605051 401 PQFTFEVgg---------rEEEVLICLQQEdrriRRKH------------GG----GE---N-LPIGFEVLK--VEV--- 446 torafugu
XP_009301387 396 PQFLFELfg---------gGEEVLICLQQEdrrmKRRE------------GS----GE---N-LPIGFEVLR--VEV--- 441 zebrafish
XP_011410135 378 PQYLFTLre----------eeEVMVSCMQKdprmSKKA-----------KTT----GEplpN-FPIGFQIVK--VED--- 426 Amphimedon quee...
XP_002107604 385 PQYAFDVtd--------geYGTTVIALMQKdkrlEKRS------------GH----GE---N-LSIGYYIMK--VAV--- 431 Trichoplax adha...
1KFX_L       443 tNIHLSKNFFLTNRARERSDTFInlREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKA 506 human
XP_001626960 432 -NRKYRVH---SMFPKAGDSIFInaREVMNRFFLAAGRYLVVPSTYEPHTPGHFMMRIFTRKRS 491 starlet sea anemone
XP_011440450 429 -NRRCRIHD-HTKQMFVESSTFKnsRSIFLQPALKAGRYVAIVCTFEPNIQGEFLFRMYSssas 490 Pacific oyster
XP_002428101 446 -NRKYRLHKILPFCQPLVSMDHQrkRELYYRGFFPAGKYLLVPTTYKPGAEGNFLIRMFSqgnl 508 human body louse
CCD74722     466 -NRPVKSHT-LAFCQVIHVEPSRpyRVCLIRERLTVGRYLVVPFMEQPLSTAAYLLRLYLPKRS 527 Schistosoma mansoni
XP_005804850 481 -NRCSRVQ---LVVEQAASSIYMdsRSVTLRGTLASGRYVVLPTTFLPGDTGRFLLRLFSHSNV 540 southern platyfish
XP_011605051 447 -NRSSRVQ---RVEEKAASSVYMdsRTVTVRATLAPGRYVILPTTFLPGVAGRFLLRVFCHAHV 506 torafugu
XP_009301387 442 -NRVCRVQ---CLCEQTASSVYMdsRSVTLRVTLGPGRYVILPTTFQPGATGRFLLRFFSHSHv 501 zebrafish
XP_011410135 427 -NRTFRIHS-MNFKE-VGRVTYInrRSNFGRFTLGQGRYVIIPSTFEPNQERQFLLRFFSERNA 487 Amphimedon queenslandica
XP_002107604 432 -NRNYRLH---TVNPKAADVTYSnsREVTGRFELEAGRYVIIPSTFQPGEDGEFLLRMYTENSA 491 Trichoplax adhaerens
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