2C6F


Conserved Protein Domain Family
Peptidase_M2

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pfam01401: Peptidase_M2 (this model, PSSM-Id:279709 is obsolete and has been replaced by 460196)
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Angiotensin-converting enzyme
Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.
Statistics
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PSSM-Id: 279709
Aligned: 63 rows
Threshold Bit Score: 702.836
Created: 8-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2C6F_A        11 SADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKElYEpiWQNFT-DPQLR 89   human
WP_023173625  33 vqsvAEAQKFMQRAEGELAELNVKANRASWVGATYITDDTEALSADAQTNLNSAIQRFAIEAKR-FD----NLQmPPELA 107  Gloeobacter ki...
WP_015456931  30 aptaadadRFVAAAEKELFDLSIPTAQVAWVNATYITDDTDALNTLFGAKNTEASVRLAKEAAR-YD--KVAGF-SFDTR 105  Sphingomonas s...
AHG87629      42 TPTAAAARLFVDSVERRLDALSVTVNQAEWVAATYITDDTEALSADAQQRYDAAAQRFALAARR-FD--GVTV--PPDLR 116  Gemmatimonadet...
XP_003377216 160 VNDETAALKFLVDYDKQAEEVFSKSAEAGWCFLTNMTANTRKELAEMDKTVVEFLHISAKRAKQ-FN--LNSIH-NKKAK 235  Trichinella sp...
WP_014076685  32 apdsaqadafvaaaEKEAFDYSVDASRIMWVNATHITDDTDALAAQAGAKGTEMAVRFALEAAK-YE--QVPGL-SFDTK 107  Sphingobium sp...
ERG84729     211 IKDPAEAKKWVDGYSAEAQKVLYQVTTAGWSYVTSVSHLTKQIFDEAEEVLAEFLKSSSKQAKQ-FD--LSSID-DPSLR 286  pig roundworm
EJW87105      57 IRDSKKAQEWMNGYAVEAQKVLREVALAGWNYVTSVSHLTKQLLDEAEETLGKFVKSSSKQAKQ-FD--IATIE-DKSLK 132  Wuchereria ban...
XP_002644637 178 IKDEEKLRSWLAGYEAEAIKVLREVALSGWRYFNDASPSLKLALDEAENVLTMFVKSTSMQAKQ-FD--KASVT-DERLK 253  Caenorhabditis...
XP_011682381  73 vlgggtsrevdgnpspdeivklfladfdrradqefpglmekqwtyytnlteenrqikveakiritefdsesrrtaqtyyh 152  purple sea urchin
2C6F_A        90 RIIGAVRTLGSANLP--LA--K--RQQYNALLSNMSRIYSTAKVCLp---------nKTATC-WSLDpDLTNILAS-SRS 152  human
WP_023173625 108 RKFKLLKLNLIAPPP--SDskE--QQELTRLTVGMESEYGKGTYCRsp-------vdGKQEC-LQLN-DLERILRT-SRD 173  Gloeobacter ki...
WP_015456931 106 RKLDILRQGIVLPAP--AT--EgaATELNALSTRMSSTYGKGRGTLa---------gKEINGs-----DIEEKMGT-VRN 166  Sphingomonas s...
AHG87629     117 RKLTLLKLAFTAPPPsdPA--K--GAELVRLTTGMEGAYGRGTYCRrgalgqpaattGDSTC-YQIN-DLSRALAE-SHD 189  Gemmatimonadet...
XP_003377216 236 KQIKNLSQEGIYVLP--EK--K--LEQFISVQAKINQVFADGTVCEp---------sRPPPCtMPLEpDLQRIMAT-SHD 299  Trichinella sp...
WP_014076685 108 RKLDIMRSGIVLPAP--TKpgA--AAELNEIATRLQSTYGKGRGTLd---------gKE----LTGS-DIEAEMANlSHT 169  Sphingobium sp...
ERG84729     287 KQLQMLSVNGMNALD--DT--S--FKEFNEIQSKINKMIAEVGICEl---------dKPPPC-LLKHaDIPSILAR-ENK 349  pig roundworm
EJW87105     133 RQFQLLLVEGINALD--EN--D--FNEYNELQKLIAKAYAETSVCEt---------nNTTIC-PYRVsDIVSIIAH-END 195  Wuchereria ban...
XP_002644637 254 RQLGYVSFEGMSALA--PS--R--FAEFSQAQSTLNRDSKDSTICDk---------dVPPPC-ALQKiDMDSIFRN-EKD 316  Caenorhabditis...
XP_011682381 153 typshqisydvrreleaiastsgsptyvdevtqeledvksrmeqryhtakvcrkkgrrarkeclrldpDLKRVMGE-SRD 231  purple sea urchin
2C6F_A       153 YAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWY-N--S----------P--------TFEDDL 211  human
WP_023173625 174 PKELLDVWQGWHQ-IARPLRPRYERFVQLSNKGARELGFADTGAMWRSNY-DmsP----------A--------QFSAEV 233  Gloeobacter ki...
WP_015456931 167 PDQLKEMWASWHDNVGKPMKADYARMVEIANQGAKELGYKDLGAMWRSNY-DmsP----------D--------EFARLT 227  Sphingomonas s...
AHG87629     190 PAVLLDAWRGWH-AIGAPLRPKYERFVALSNEGARELGFADLGAMWRANY-D--M----------Pa------dQFPREV 249  Gemmatimonadet...
XP_003377216 300 VNELYYVWLAWRNAVGPPMKQSYLEMVELFNEIAKLNGLKHGGEIWQNTYgE--K----------V--------NLINLL 359  Trichinella sp...
WP_014076685 170 PAQFSEMWTSWHDRVGAPMKADYVRLVDIANEGAKELGFADAGAMWRSGY-DmpP----------D--------EFAALT 230  Sphingobium sp...
ERG84729     350 AENAQHIWMAWRRAIAEDLAPSYERLMQLTNQGAVLNGFSDGGAMWRSPY-D--L----------SieggraklNMLEEL 416  pig roundworm
EJW87105     196 GPKAFRLWIALRDALGPKLVTSYKRLIELINKGAKLNGFSDGGAMWRSPY-E--LlvsrqekaeqS--------DTVVLL 264  Wuchereria ban...
XP_002644637 317 ASRLQHLWVSYVTAIAKS-KPAYNNIIAISNEGAKLNGFANGGAMWRSAF-D--T----------Psn----maDLTKQV 378  Caenorhabditis...
XP_011682381 232 DDELLWAWQGWRNETGAPNRDDFQRFVELSNTVAQQSGFDDHGDYQRRQY-D--T----------P--------HLEQTM 290  purple sea urchin
2C6F_A       212 EHLYQQLEPLYLNLHAFVRRALHRRYG---DRYIN---LRGPIPAHLL-----GDMWAQSWENIYDMVVPFPD--KP--N 276  human
WP_023173625 234 ERLWQQVRPLYLSLHAYVRTKLGEQYG---TQLVP---ADGPIPAHLL-----GNMWAQEWGNIYPLAAPAND--QR--G 298  Gloeobacter ki...
WP_015456931 228 DKLWLQVKPLYDQLHCYTRTKLNEKYG---DGVQP---RTGPIRADLL-----GNMWAQEWGNIYDVVAPAGA--GDl-G 293  Sphingomonas s...
AHG87629     250 ERLWKQVEPLYVALHAYVRTRLNQQYG---DAVVA---KDGMIPAHLL-----GNMWAQEWGNVYPIVAPPNA--SP--T 314  Gemmatimonadet...
XP_003377216 360 EKIYDEVRPLYDQLHAYIRNQLRKQY----ASFMH---QDGQIPAHLLvkfstGDMSGSNWINLYPDSVPYPE--HH--P 428  Trichinella sp...
WP_014076685 231 EALWQEVKPLYDALHCYTRTKLNEKYG---DAVQS---PTGPIRADLL-----GNMWAQEWGNIYPIVAPAGT--GDl-G 296  Sphingobium sp...
ERG84729     417 NRLFEQILPFYKQLHAYVRRQLAGIYG---IENVPqltKDGPIPAHLL-----KSIAGDSWVALYHETKPFDS--DDirS 486  pig roundworm
EJW87105     265 QKLYQQINPFYKQLHAYIRRQIPALYGltnVSSLT---RDGPIPAHLL-----KSIAGDNWIAFYRDTKPFQD--ED--D 332  Wuchereria ban...
XP_002644637 379 EKIYSTIQPFYQLLHAYMRRQLAGIYSn--PAGLS---KDGPIPAHLF-----GSLDGGDWSAHYEQTKPYEEesET--P 446  Caenorhabditis...
XP_011682381 291 SDLLTNLQPLYDNLHAFIRRRLYDIHG---PEVID---LNGPIPSHLL-----GGMWSHSWSNLFDVAKPYETd-DD--- 355  purple sea urchin
2C6F_A       277 L--DV---------------------TSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADgREVVCH-A 332  human
WP_023173625 299 Y--DL---------------------TQLLTAKKVDEREMFRYGERFFTSLGFAPLPKTFWERSMLTKPRD-RDVVCH-A 353  Gloeobacter ki...
WP_015456931 294 Y--DT---------------------TDLLKAKGYDALKMVKGGENFFSSLGFAPLPDSFWQHSQFTKPAD-REVICH-A 348  Sphingomonas s...
AHG87629     315 Y--DL---------------------TALLKAKNVDAKGMAKYAEGFFTSMGFAPLPATFWERSMLVKPRD-REVVCH-A 369  Gemmatimonadet...
XP_003377216 429 L--DV---------------------NYHLKSLNYTVEKMVRTAEKLFTSMGFGRLPKSFWDYSIFVRPND-RDMVCY-P 483  Trichinella sp...
WP_014076685 297 Y--DIgdllrakgfvqttpqtidtpdTPETQRRGYWEKQMFRIGEGFYSSLGFDPLPETFWQRTQFIAPRD-REVVCH-A 372  Sphingobium sp...
ERG84729     487 E--QI---------------------LENLQRLNYTAKGMFVEAYKYFKQLGFGKLPKPLWTKSVFSRTWS-KDMVCQ-P 541  pig roundworm
EJW87105     333 LarEV---------------------QDNLQKRNYTVKNMFKQAYKTLKQIGFNKLPSSFWTKSIFTRTWS-RDMLCHpP 390  Wuchereria ban...
XP_002644637 447 E--AI---------------------LAAFTSQNYTTKKMFVTAYRYFKSAGFPQLPKNFWTSSIFARVWS-KDMICHpA 502  Caenorhabditis...
XP_011682381 356 ---DP---------------------TEFLQEQNYDIRRLYETAEEFYTSMGYEELPESFWENSVFGQLQDgRNVSCE-P 410  purple sea urchin
2C6F_A       333 S-AWDFYNRKDFRIKQC-TRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGL 410  human
WP_023173625 354 S-AWDIDNLDDVRIKMC-AEVTDSDFVTIHHELGHNFYQRAYKTQPPLFQNSANDGFHEAVGDTIALSV-TPDYLVKVGL 430  Gloeobacter ki...
WP_015456931 349 S-AWDVDNKDDLRIKMC-IKVNGDDFTTIHHELGHNYYQRAYNKQPYLYLNGANDGFHEAIGDAIALSI-TPDYLVRIGL 425  Sphingomonas s...
AHG87629     370 S-AWTIDNKNDVRIKAC-LEPTADDFVTIHHEEGHNFYQRAYSSQPYLFQNGANDGFHEAIGDAIALSI-TPGYLQQAGL 446  Gemmatimonadet...
XP_003377216 484 A-AFDFKNQKDFRIKMC-AQVTWEDFIQLIRQMTSTYYQIAYKEQPISFREAANPAISYALTNALALSVSSEDFMHSVGI 561  Trichinella sp...
WP_014076685 373 S-AWDVDNRNDIRVKMC-TKVNSDDFVTIHHELGHNYYQRAYQKHGYLYLNGANDGFHEAIGDFIALSI-TPQYLVQIGL 449  Sphingobium sp...
ERG84729     542 SvAYDMRDGNDFRIKSC-AQLGDTDFKMAHKLIAQVYYEYLYREQPLPFREAANPSILAAITNAFSLLATNTDYLKSLQL 620  pig roundworm
EJW87105     391 A-AYDMRNELDYRVKAC-AHLNLPDFELTHKLLVHIYYYYMCREQPLLFREATNPSFLTAVTNAFAINARNIEYLKMMKL 468  Wuchereria ban...
XP_002644637 503 A-ALDMRAPNDFRVKSC-AQLGEPDFEQAHSLLVQTYYQYLYKDQSLLFREPASPVITDAIASAFAYLATNPHYLYSQKL 580  Caenorhabditis...
XP_011682381 411 T-SWDFHNQTDFRITTCsSEVTIDELSKAHNILGHTQYQNSYSHQPTAFREPASPALYEAIADLTSSEVFSPSYLRQLGL 489  purple sea urchin
2C6F_A       411 L-D-RV-TND--TESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFD 485  human
WP_023173625 431 L---GK-APG--PESDTGFLLKQALDKVAFLPFGLLIDQWRWKVFSGETQPKDYNKSWWELRERYQGIAPPLARSEADFD 504  Gloeobacter ki...
WP_015456931 426 L-DpAK-VPP--ADKDIGLLLRQAMDKVAFLPFGLLVDKWRWGVFDGSIAPQDYNKAWTALRLQYQGITPPVERGADAFD 501  Sphingomonas s...
AHG87629     447 L-A-T--PPS--AAADTALLLRQALDKVAFLPFGLMIDQWRWGVFSGAIKPSEYNKAWWDLRARYQGVVPPVARSEADFD 520  Gemmatimonadet...
XP_003377216 562 L-P-DL-ENS--QEKTINYLYNIALREVAFIPYGVLADKWRWSLFSGDIDATNMNEKWWEYRMKYQGVKSPARRDSNDFD 636  Trichinella sp...
WP_014076685 450 L-DpAK-VPS--ADKDIGLLLRQAMDKVAFLPFGLLIDRWRWGVFDGSIRPADYNKAWTDMRLRYQGIVPPTDRPADSFD 525  Sphingobium sp...
ERG84729     621 L-P-ATaSEG--QAAQVNGLYFQALGEFVKLPFDLVADNWRFNIFEGKTNKDTWNDDWWRLSEHYQGVKPAARRSATDFD 696  pig roundworm
EJW87105     469 ItS-ET-GYS--RSKIINRLYLEALEDFVKLPFDFAVDMWRFHIFDGTSTDVTWNSDWWHLSELFQGIKSPVDRKSTDFD 544  Wuchereria ban...
XP_002644637 581 V-P-SD-HLDikNSVIINKLYKESLESFTKLPFTIAADNWRYELFEGKVPKNKLNDRWWEIRNKYEGTRSPQPYNTSNLD 657  Caenorhabditis...
XP_011682381 490 SlD-ER-NDD---KIQLNGLMRTALDSLALLPYANAVDQWRWGVFNGSIQPDRYNSEWWDLRSEYEGIEPGVERTDADFD 564  purple sea urchin
2C6F_A       486 AGAKFHVPN-VTPYIRY--FVSFVLQFQFHEALCKEAGYegpLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGL 562  human
WP_023173625 505 PAAKYHVAA-NTPYIRY--FLARILQFQFHRALCREAGYtgpLHRCSIYANRAAGTKLAAMLAAGQSQPWPDTLYAMTGE 581  Gloeobacter ki...
WP_015456931 502 PGAKYHVPA-STPYTRY--FLARILQFQFYKAACDQAGWkgpLHRCSFYGNKEVGANLNKMLEMGMSKPWPDALQAFTGS 578  Sphingomonas s...
AHG87629     521 PGAKYHVPA-NTPYMRY--FLARVLQFQFYRAMCRAAGHtgpLYRCSFYGSKEAGAKLARMLEAGQSKPWQETLYEMTGE 597  Gemmatimonadet...
XP_003377216 637 PGSNYQIAQ-NLPFSRQvnVIGYVIQFQVLKGLCSAIGYqgpLHRCHFFEGKLAGEKLISAMKLGASENWTDVLKILSGS 715  Trichinella sp...
WP_014076685 526 PGAKFHVPG-NTPYTRY--FLARILQFQFYEAACRQAGWkgpLHRCSFYGNKEVGKRLNAMLEMGASKPWPDALEAFTGS 602  Sphingobium sp...
ERG84729     697 AIAAPAIAQmHSPAMRH--FIGYIMQFQILKALCRNTTS---LHEGCRLQ-KSSVENMKKVMMLGSSINWMEAMKMLTGS 770  pig roundworm
EJW87105     545 AIAFSTIAQtHAPAMKH--FFAYIMQFQILKALCPNATN---LGNGCMLERSPAIDKIKKVMALGSSITWREALEIITGR 619  Wuchereria ban...
XP_002644637 658 ALIHNSVSQvNSPATRS--LISYVLKFQILKALCPEGTI---LSEGCIL-SEDTTEKLRETMKLGSSITWLKALEMITGK 731  Caenorhabditis...
XP_011682381 565 PGAEFNIVS-DSSYAKH--FLGQIMKFQFLKSLCEAAGHtgpIQDCNLYGNRVAGqlit--------------------- 620  purple sea urchin
2C6F_A       563 DALDAQPLLKYFQPVTQWLQEQNQQNGEVLGW 594  human
WP_023173625 582 RQMDASAMLDYFAPLKSWLDAQN--QGKKVGW 611  Gloeobacter kilaueensis
WP_015456931 579 REMDGTAMIAYFKPLMTWLEQQNK--GKTCGW 608  Sphingomonas sp. MM-1
AHG87629     598 RDMDAGAMLEYFAPLKAWLDRQNA--GHPVGW 627  Gemmatimonadetes bacterium KBS708
XP_003377216 716 EEISGAAMMEYMEPLIQWLVKTNAETGETIGW 747  Trichinella spiralis
WP_014076685 603 RKMSGKAMLAYFAPLGKWLDQQNK--GKQCGW 632  Sphingobium sp. SYK-6
ERG84729     771 DQLDAKPLLEYYEPLISWLGNANEHDQVVVGW 802  pig roundworm
EJW87105     620 KEVDANAMLEYYQPLISWLEEENAKEHAYIGW 651  Wuchereria bancrofti
XP_002644637 732 GELDAQPLLEYYEPLINWLRNTNEIDQVVIGW 763  Caenorhabditis briggsae
XP_011682381     --------------------------------      purple sea urchin
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