4JKV


Conserved Protein Domain Family
Frizzled

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pfam01534: Frizzled (this model, PSSM-Id:279827 is obsolete and has been replaced by 396219)
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Frizzled/Smoothened family membrane region
This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.
Statistics
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PSSM-Id: 279827
View PSSM: pfam01534
Aligned: 94 rows
Threshold Bit Score: 226.316
Threshold Setting Gi: 357625301
Created: 20-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JKV_A        141 LfteaehQDMHSYIAAFGAVTGLCTLFTLATFVADWrN-S-NRYPAVILFYVNACFFVGSIGWLAQFMDg-aRREIV-CR 216 
XP_011054584  224 LytpdehNQIHSFIIWAASICCTFNLFTVLTFVIDWrS-A-NKYPALVIFYINGCFMVSCIGWLIQFTPg--SRDVViCH 299  Panamanian le...
XP_001842080  239 LftdhehRQIQKLIAWGAGVCLTFNLFTLATFIIDWhN-A-NKYPALVIFYINFCFMVSCLGWLAQFTPg-gREDIV-CR 314  southern hous...
XP_002077615  244 LytddehRQIHKLIGWAGSLCLLSNLFVVSTFFIDWkN-A-NKYPAVIVFYINLCFLIACVGWLLQFTSg-sREDIV-CR 319  Drosophila si...
XP_002425290  215 litkneyEQIHKMIGWGATASLFCNLFTVVSFLIEW-R-SgNKYPAVIIFYINICFLLSNLGWLAQFLPk-aREDIV-CK 290  human body louse
NP_001127850  208 LytenehYQIHKLIGYCVLVCGLFNFFTIVTFIIDW-TtA-NKYPALSIFYMNICFFISYSGWFIQFLStdtREDIV-CK 284  red flour beetle
EFX80809      225 LftkeehEQVQRFTQTLVAMCLTTNLFAVFTFMIDWrS-A-SRYPAVIIFYMNVCFAAACIGWIAQYIPs-aRQDII-CR 300  common water ...
XP_008186524  202 LfsmdehRQIHNLIAWTATIAGLCNIFAILTFMIEW-Q-SlNRYPNIVILYINICFLFICFGWLSQFWSg-tRDDIV-CR 277  pea aphid
XP_004931775  231 LytedehQQIHKLVAWGAGVCLALNLLTVATFLIDWrS-A-NKYPALVIFYINVCFAVASMGWLVQFGVg-sRDDIV-CS 306  domestic silk...
XP_002411600  152 LltederLGMRTFVVVVSSIATLTSLFAVLTFMIGWkE-S-RQYPNVMVFYINLCLLLMCVGWLAQFVPg-aREDIT-CR 227  black-legged ...
4JKV_A        217 ADGTMRLGEPTSN--ETLSCVIIFVIVYYALMAGVVWFVVLTYAWH------T--S-FKALG--TtyQPLSGKTSYFHLL 283 
XP_011054584  300 KDGTLR---TREPsgENLSCVIVFVLVYYSLMAAAVWFVILTYAWHm-----S----FRALGtiQ--DRIDKKSAYFHLI 365  Panamanian le...
XP_001842080  315 KDGTLRSSEPSAG--ENLSCIIVFILVYYFLIAAMVWFVIFTYVWHm-----SfkA-IGKIG--K--DRIDKKGSYFHLI 382  southern hous...
XP_002077615  320 KDGTLRHSEPTAG--ENLSCIVIFVLVYYFLTAGMVWFVFLTYAWH-----------WRAMG--HvqDRIDKKGSYFHLV 384  Drosophila si...
XP_002425290  291 KDMTLRRSEPSAE--ENLSCVVIFVVIYYFLMAACVWFVIFTYAWHl-----S--CrGLAKI--Q--ERIDKKGAYFHLV 357  human body louse
NP_001127850  285 KDGTLRKSE--PSatENLSCVIVFVLVYYFLIAGMVWFVLFSYTWHm-----S--C-VQALGkiQ--ERVDKKRVYFHLI 352  red flour beetle
EFX80809      301 KDGTARVSE--PSggETLSCVVIFILIYYFLMAACVWFVMLAYSWFv-----S----FQALGkiR--EKVSSKAAYFHLV 367  common water ...
XP_008186524  278 KNGARKTSEPs---dEDLSCVINFVFSYYFLIAAFIWFVIFTYSLH------T--T-FQSFGkiQ--EKVDKKGGYFHLL 343  pea aphid
XP_004931775  307 KDGTRRQGEPSAE--ENLFCVVVFVLVYYFMMAACVWFVIFTYAWHm-----C--S-FRALGkiQ--DRIDKKAAYFHLV 374  domestic silk...
XP_002411600  228 RDGTLRSGEPSSG--ENLSCVVIFCLVYYFLLAALCWFVMLTYAWDhrfqtrA--S-VP-----R--ESLDAKAAYFHLI 295  black-legged ...
4JKV_A        284 TWSLPFVLTVAILAVAQ------VDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPgLL 357 
XP_011054584  366 AWCIPLVLTVAIMALGR------IDGNSITGICFVGYADHMA-KIFVLGPILLAVLIGGYFLCRGLYTLIC----LK-IS 433  Panamanian le...
XP_001842080  383 AWSLPLVLTITIMALSE------IDGNGTVGICFVGYINHPIRGGFLLGPVVCVLFIGGYFLGRGLLTLIKLKISSKeII 456  southern hous...
XP_002077615  385 AWSLPLVLTITTMAFSE------VDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLF----GLK-HF 453  Drosophila si...
XP_002425290  358 AWSLPVVLTITVMASRQ------IDGNSMAGICFVRSSYWGARVVFLLVPIAVTILMGGYYLVRGLSFLFNV----K-KD 426  human body louse
NP_001127850  353 AWSLPLMFTITTMAVGE------IDGDYVTGICFVGIFNFAARAGLLLAPLAVTMIVAGYIIVRGLVLLIKV----K-ID 421  red flour beetle
EFX80809      368 SWSIPLVLTITCMALAQ------VEAQSPHGICFVAN-SKVVRSGFVLAPVMILLCIGHVFLYRGLLILIR----LK-LG 435  common water ...
XP_008186524  344 AWSIPLVFCVVVMVLGE------IDGDSVTGTCFVGVNNKIYSIIFVLIPVLISVLIGLFYLVRVLFGLL----ALK-KE 412  pea aphid
XP_004931775  375 AWSLPLILTITTMAFGE------VDGSSVTGVCFVGYVNHPMRAALLLAPLAVVLTLGGYFLLRGVFSLVVVRVSSK-DV 447  domestic silk...
XP_002411600  296 AWCVPFVLTITVMALGKashslcVDGDPVSGICFVTSANPIVRSAFVLLPVTVAFFVGGYFLVREFYKLI----TLK-VS 370  black-legged ...
4JKV_A        358 -----SE-----KaASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRdyvlcqanvti-glptkqpipd 426 
XP_011054584  434 -----SQeiiseRaSSKIKQTIVRMGLFSIGTLAAVVITFYCHIYEIQNSQQWQKSFRsymicti--------askyadv 500  Panamanian le...
XP_001842080  457 -----SA-----RaSKKIRQTIVRMGICTMLTFVFIVATVFCHIHEFRHAESWALSLKnyiicqis-------stytdvt 519  southern hous...
XP_002077615  454 andikST-----SaSNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWSQSFRqfiickis------svfeekss 522  Drosophila si...
XP_002425290  427 -----SQqilsdKaSAKIREMIVRIGLFSVFCLTFVIVTFMCHIYEFAHEEDWQKSFRnyifcsi--------lssksdp 493  human body louse
NP_001127850  422 -----SReiiseHsSRKIRSNIVRMGVFTLFMIVFCIITFIYHGYVFVNSETWNLSLQsyilcklt------slssdfsh 490  red flour beetle
EFX80809      436 saasiSA-----SaNSKLRNTIVRLVSFSASIICALGLTIFCHVYEFDRRNQWKTSFRsymvclanqntsriqnqgladd 510  common water ...
XP_008186524  413 -----STqviskQaKSKIHSAAIKVIMFMILIVVFVSSMFMCYIYEYNNDHLWKDSLRkyivck-----------lgiip 476  pea aphid
XP_004931775  448 i----SP-----RaSNKIRRTITRCSITAALVAVFICVTFACHIYEFRNADLWKDSFKrniicrle------agqerqke 512  domestic silk...
XP_002411600  371 -----NSdvlndRvRTKIQSMILRIGLFVVTMVLLVSCTFVCHIYEFKSQPVWTESLRnyvacranvgaaqrflpeepqs 445  black-legged ...
4JKV_A        427 C------EIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTW 469 
XP_011054584  501 Se----cKMDSRPSTGKLQLHLLALFSTGIFMSSWIWTSSTVDTWCRFL 545  Panamanian leafcutter ant
XP_001842080  520 St----cKLQSRPSVAVLQIHLICLFASGIVMSSWVWTNSTLETWGRYF 564  southern house mosquito
XP_002077615  523 Cr------IENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYI 565  Drosophila simulans
XP_002425290  494 Rd----cQMESRPSIAMIQLHLLIIFAAGIVMSSWVWISSTAETWRRFF 538  human body louse
NP_001127850  491 C------KQESRPSVAMLQLQLLAVFGAGIAMASWVWCSATLHSWTRYI 533  red flour beetle
EFX80809      511 C------ELESRPSMTITQVHLIAVFGAGVAVSSWVWTKASVLAWRRWY 553  common water flea
XP_008186524  477 DtdigncRIEFKPSVSKKQLYILVLFGNAVLMSFWVWTNQIGNAWCECL 525  pea aphid
XP_004931775  513 Cl------TGSRPSISVLQLRLLCCFAAGALMSSWTWTPAALAAWRRYL 555  domestic silkworm
XP_002411600  446 C------DPGSRPSLAMLQLHLVAFLGACVALSSWVLTAATAATWKRFW 488  black-legged tick
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