4K1C,4KJS,4K1C,4KPP,3V5S,4KPP,3V5S


Conserved Protein Domain Family
Na_Ca_ex

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pfam01699: Na_Ca_ex (this model, PSSM-Id:279963 is obsolete and has been replaced by 426387)
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Sodium/calcium exchanger protein
This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Statistics
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PSSM-Id: 279963
Aligned: 99 rows
Threshold Bit Score: 39.1128
Created: 11-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4K1C_A 257 SSLVILLGTTVIISFCADFLVGTIDNVV-ESTGLSKTFIGLIVIPIVGNAAEHVTSVLVAM-----KDK---MDLAL--- 324 Saccharomyces cerevis...
P34322 513 YSYSGFIMSIAWIYLISSEVVNVVTMLG-VVSRVSHEVLGLTILAWSNSIGDLIADVSVVK-----QGY---PRMAM--- 580 Caenorhabditis elegans
Q9LJI2 479 WVLGGFIMSIVWFYMIANELVALLVTFG-EIYGINPSILALTVLAWGNSMGDLVSNIALTM-----NGGd-gVQIAL--- 548 thale cress
Q9FKP2 397 WLAGGFVMSMTWSYISAQELVALLTSLG-YIFGVSPSILGLTVLAWGNSIGDLITNLTMAL-----HDGnegAQVAV--- 467 thale cress
Q9FKP1 405 WLLGGFTMSVTWTYMIAQELVSLLISLG-NIFGISPSVLGLTVLAWGNSLGDLIANVTVAF-----HGGndgAQIAL--- 475 thale cress
O04034 388 VIVVAFIMSVFWISTIAGELLNCLAALG-TLLKLPPALLGLTVLAWGNSVGDLVADVAVAK-----AGR---PAMAM--- 455 thale cress
Q9HN44 189 RAWARLAAGLAAISVAVELLVGAVTGLAaT-FDIPSFLAGVTILAAATSLPDALVSVRAAR-----SGH---GVTSL--- 256 Halobacterium salinarum
P47144 530 FLAIGIINIIIWISLLANSLIEMMEIYQ-KILGLSKAILGLTIFAWGNSVGDLISNISMCRlyktqTHYqdrVRLATkff 608 Saccharomyces cerevis...
O27223 183 KKLALTVVGFAGLVIGCRILVYTGVELA-DIAGIPAMIMGLFTLAIGTSIPELVVTLSSAV-----KGL---HELSI--- 250 Methanothermobacter t...
O27145 176 KTIISAILGFTGLVVFCRILVYSAVGIA-EIMNVPEMIIGLFALAIGTSLAELVVAVNSAM-----KRM---CSLSL--- 243 Methanothermobacter t...
4K1C_A 325 ----GVAIGSSLQVALFVTPFMVLVG----WMIDVP---------------MTLNF-STFETATLFIAVFLSNYLILd-- 378 Saccharomyces cerevis...
P34322 581 ----AAAIGGPLFNLLMGFGLPFTIAk--lQGKYISm-------------tINPTY-RL--L--ILFLAISLLATLIgip 636 Caenorhabditis elegans
Q9LJI2 549 ----SGCYAGPMFNTLVGLGMSMLFGa--wSKSPDTy-------------mLPEDK-SL--FYTLGFLVLGLVWAMVilp 606 thale cress
Q9FKP2 468 ----SGCYAGPIFNTLFALGISLVGCa--wEAYPLSi-------------vIKTDP-RL--LESLGFLVAGLVWSFLvlf 525 thale cress
Q9FKP1 476 ----SGCYAGPLFNTVIGLGVPLVISs--lAEYPGVy-------------iIPSDN-SL--LETLGFLMVGLLWALVimp 533 thale cress
O04034 456 ----AGCFAGPMFNMLVGLGSALVMQt--aNVYPDAy-------------kLGFHV-GI--VIAFVFLLLSLMGSLLvit 513 thale cress
Q9HN44 257 ----GNVLGSNTFDLLVAIPIGVLI-------AGR----------------APVSFaVAAPLMGVLTLATVLLFTVLrt- 308 Halobacterium salinarum
P47144 609 miscASCLGGVMLNSMGGIGFSGLVSmlfiGAFNDNewwflrkvklqetsqLDNTL-NYKFIVSCVFIILQIILLLLffg 687 Saccharomyces cerevis...
O27223 251 ----GTVLGSNTFNILVGIGVPALIAp----VPVERl-------------sLTFDA-PVMILVTVLL---VLLIRqg--- 302 Methanothermobacter t...
O27145 244 ----GTVLGSNIFNILIGIGVPSLFVr----IPVEPl-------------sLILDA-PVLMGVTV-A---VMYFMwt--- 294 Methanothermobacter t...
4K1C_A 379 ---------GESNWLEGVMSLAMYILIAMAFFY 402 Saccharomyces cerevisiae S288c
P34322 637 ------vqkFRLQRPHAAVLISIYIAFIVFVIL 663 Caenorhabditis elegans
Q9LJI2 607 ------rndMQPSRTLGVGLIAIYLIFVTFRLS 633 thale cress
Q9FKP2 526 ------snrMRLGGVMGIGLLVIYLASLSLRIM 552 thale cress
Q9FKP1 534 ------kkkMRLDKLVGGGLLAIYLCFLSLRLA 560 thale cress
O04034 514 ------wsrFRVPRFWGICLVGLYVAFTFVSLI 540 thale cress
Q9HN44 309 --------gLSLTDAESYALLVAYLGFVAWIIG 333 Halobacterium salinarum
P47144 688 gpnnikrrlTKEMKLVGISMCGLWALATLINIL 720 Saccharomyces cerevisiae S288c
O27223 303 --------dMKLKRTGGIVLLAVYISYVIMRLF 327 Methanothermobacter thermautotrophicus str. Delta H
O27145 295 --------dMELRRVEGVALVAFYLAYAVIRIT 319 Methanothermobacter thermautotrophicus str. Delta H
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