3DOU,2NYU,4K6M


Conserved Protein Domain Family
FtsJ
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pfam01728: FtsJ (this model, PSSM-Id:279986 is obsolete and has been replaced by 426399)
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FtsJ-like methyltransferase
This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.
Links
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Statistics
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PSSM-Id: 279986
Aligned: 238 rows
Threshold Bit Score: 50.6604
Created: 21-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3DOU_A    5 LRSRAAFKLEFLLDRYRvVRKGDAVIEIGSSPGGWTQVLNSLa--RKIISIDLQEX----EEI--A-----GVRFI-RCD 70   Thermoplasma volcanium
Q80DQ2 2511 YVSRGGLKLDEVIRKYN-WKPNGRVVDLGCGRGGWSQRVVMEesvSSVYGYTVGGQek-eVPQkfL-----TKGYN-LTN 2582 Kamiti River virus
Q09TQ0  912 PVSRGAAKLHWLVERGF-LEPKGWVTDLGCGRGGWSQYTATLpqvTRVVGYTLGTGgh-eKPIptEsyghnIITYHdKVD 989  Ngoye virus
P29837 2565 AVSRGTSKLAWMEERGY-VTLKGEVVDLGCGRGGWSYYAASRpavMSVRAYTIGGKgh-eSPRmvTslgwnLIKFRaGMD 2642 Langat virus (strai...
A0EKU7 2571 AVSRGTSKLAWMEEGGY-VEHTGRVVDLGCGRGGWSYLAASKtkvMEVRGYTLGIDgh-eVPRlvEsfgwnIIKFKsKVD 2648 Saumarez Reef virus
Q9JAD5 2537 AVSRGTSKLAWMHERGF-IPLSGHVVDLGCGRGGWSYYCAAQtpvRKVNAYTLGTGah-eKPRlvEslgwnLITFKsKTD 2614 Rio Bravo virus
Q9J9C2 2529 AVSRGTSKLAWMHERGY-VPLKGVVVDLGSGRGGWSYYAAAQervRKVNAYTLATTkgheQPRlvQsygwnLVTFK-KAD 2606 Apoi virus
Q67483   54 AVSRGSSKLNWLIERGY-LRPTGRVVDLGCGWGGWSYTCAAErqvTSVKAYTLGKEgh-eKPRliQslgwnIIKFKdKSD 131  Banzi virus
Q89277 2560 AVSRGTAKLRWFHERGY-VKLEGRVIDLGCGRGGWCYYAAAQkevSGVKGFTLGRDgh-eKPMnvQslgwnIITFKdKTD 2637 Yellow fever virus ...
4K6M_A   54 PVSRGSAKLRWLVEKGF-VSPIGKVIDLGCGRGGWSYYAATLkkvQEVRGYTKGGAgh-eEPMlmQsygwnLVSLKsGVD 131  Japanese encephalit...

3DOU_A   71 IFKETIFDDIDRalreegiekVDDVVSDAXAKVSGiPSRDHAVSYQIGQRVXEIavRYLRNGGNVLLKQFQ--GDXTNDF 148  Thermoplasma volcanium
Q80DQ2 2583 LKSGVDVYRLPPt-------rCDTIMCDIG-ESDPnPAKEKTRTLKVLELLENW--LSVNPSAEFVCKILSpySLEVLRK 2652 Kamiti River virus
Q09TQ0  990 VMRLPPHL-------------CDTVMCDIGESSSN-VEVEAGRTVAVIEMFANW--LEANPGAQFCCKVLCpyHPDVLAT 1053 Ngoye virus
P29837 2643 VFSMEPHR-------------ADAILCDIGESNPD-AVVEGERSRRVILLMEQW--KNRNPTATCVFKVLApyRPEVIEA 2706 Langat virus (strai...
A0EKU7 2649 VFRMRPER-------------VDTILCDIGESSPK-WQIESERTMRVLDLLEKW--KAESPAAEFVVKVLCpySAEVMER 2712 Saumarez Reef virus
Q9JAD5 2615 VFKLKPYS-------------CDTVLCDIGESNPS-YATEAKKTLEVIEMVGNW--MLVNPESNFCFKVLNpySPQVLER 2678 Rio Bravo virus
Q9J9C2 2607 VRTIEPYP-------------VDTLLCDIGESSSS-SSIEAKRTLQIMDVVGKW--LEISPGASFCIKILCpyNPEVIEH 2670 Apoi virus
Q67483  132 ITRMTPHA-------------SDTLLCDIGESSSN-PEVEKERTLRVIEAVEKW--MSPT-TVSFCFKVLApyKPDVIEA 194  Banzi virus
Q89277 2638 IHRLEPVK-------------CDTLLCDIGESSSS-SVTEGERTVRVLDTVEKW--LACG-VDNFCVKVLApyMPDVLEK 2700 Yellow fever virus ...
4K6M_A  132 VFYKPSEP-------------SDTLFCDIGESSPS-PEVEEQRTLRVLEMTSDW--LHRG-PREFCIKVLCpyMPKVIEK 194  Japanese encephalit...

3DOU_A  149 IAIWRKNFSSYKISKPpASRGSSSEIYIXFFGF 181  Thermoplasma volcanium
Q80DQ2 2653 IETLQQKHKGRLVRLT-YSRNSTAEMYYVSGSR 2684 Kamiti River virus
Q09TQ0 1054 LEILVREHGGGLVRVP-LPRNSTHEMYWVSGVK 1085 Ngoye virus
P29837 2707 LHRFQLQWGGGLVRTP-FSRNSTHEMYFSTAIT 2738 Langat virus (strain TP21)
A0EKU7 2713 LSAMQRRWGGGLVRNP-FSRNSTHEMYYTSRAG 2744 Saumarez Reef virus
Q9JAD5 2679 LTKFQHMFGGGIIRVP-HSRNSTHEMYFVSGIT 2710 Rio Bravo virus
Q9J9C2 2671 LSRWQHQFGGGLVRVP-HSRNSTHEMYFVSGGG 2702 Apoi virus
Q67483  195 LERFQLKHGGGIIRNP-YSRNSTHEMYYVSGVR 226  Banzi virus
Q89277 2701 LELLQRRFGGTVIRNP-LSRNSTHEMYYVSGAR 2732 Yellow fever virus strain French neurotropic vaccine
4K6M_A  195 MEVLQRRFGGGLVRLP-LSRNSNHEMYWVSGAA 226  Japanese encephalitis virus
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