Conserved Protein Domain Family
REJ
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pfam02010: REJ (this model, PSSM-Id:280229 is obsolete and has been replaced by 366875)
REJ domain
The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.
Links
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Statistics
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PSSM-Id: 280229
Aligned: 25 rows
Threshold Bit Score: 165.376
Created: 22-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A0FEM3       1521 ARVKIN--CTS-VKYAFYTWQAYEVANDGRETEIYDLGDSvMSGYTQRElai-kkfVLPYGLYAFQLNVSMYGERG-VET 1595 purple sea ur...
A0FEM4       1482 STVRLR--CYGlEETPQFQWSTKMIDDLNGTFTDLDNEA--LPDYTFPPl------TFAVALYNLTMTVTVTETSPpLSG 1551 purple sea ur...
A0FEM5       2089 sssdafaeAADdVSSIAESFGSSSVAEVASSSIQEEPATVdLS-TMLPTs---------TGL------------------ 2140 purple sea ur...
Q4T3T9        639 ASVVSN--CS--AYNIRYQWEVLTLSATYPEIMLSDNKARlGGQEAASLlllipkhSLSVGQYCLLFTVSLQGTP--LQV 712  spotted green...
Q8MVW7       1353 TPVISFpsCYS------------------------------GSG---------------ATTYTFALDGSVSK------- 1380 Naegleria gru...
Q54XQ9       1128 SSCSVDgaSQN-TNTIKYKWSI------VPEIQLASSKDYtGPTLNIPSs-----kWVYDTTYVITLTATSGKETN---- 1191 Dictyostelium...
Q229K3        637 ETCELGqiTFF-NEPVDLQLTSNQLQKQSLSQYIQSSFQYdIPPYSLASn----------QTFNISLTLNLSSDSN-IAA 704  Tetrahymena t...
XP_001627539 2101 AKAVLSp-CLD-PSVAASVLFSWEIDAVGIDLGVTDKPRLrIKQATLEGg----------KTYTLTVTAAMASDQT-LSS 2167 starlet sea a...
NP_001075434 2017 ADIKYYseCVA-AGETVIEWSVNDTSVALNLFTMYTRALRv-DEGSLPGg------A----TILFTVRVYKSSTPS-QVT 2083 purple sea ur...
NP_001075437 2353 AAVRFYeaCGG-AEQMEYAWSVDDDSIALNLQTINKPLLDvAAG-SLPGd------S----QVTFTLEVNRESDPS-TVT 2419 purple sea ur...

A0FEM3       1596 LDRTKLRVKATPLIAKITGGSEIRVRW-ND-KIYMDGLAe-TIDP-D--------VDPSDK--SGIRYVWICRREHeaf- 1660 purple sea ur...
A0FEM4       1552 IDYVYMRIDSTPLIVVISGGTARTVNG-KL-DIQFNATE--SQDP-D--------EELGDQdlSKWNFTWSCYRED---- 1614 purple sea ur...
A0FEM5       2141 -------LATSDLSTPSEGATSVTEEA-E------ETTH----QPsD--------EDSILEdySDSNYEYpdd------- 2187 purple sea ur...
Q4T3T9        713 QQNTTITVVNAPLVAVIKGGSKRLWPH-LS-DLTLDGSE--SQDL-D--------REQGEE--DMLKYDWSF-------- 769  spotted green...
Q8MVW7       1381 -------VSSLSVVTK-------------D-NLMVLGSGytNFNQ-E--------GD----------YYFIITASAasaq 1420 Naegleria gru...
Q54XQ9       1192 YDNVTVIISKKPITAVIDG-ADKEFPL-NT-LITLDASK--SFDPtTtstvskelDDSTSTqqQSFTYAWRCINKS---- 1262 Dictyostelium...
Q229K3        705 IQNISVNIQITDLYLQIIGGSSLVQGY-QN-QMILNTDSr-DYEI----------QDPNSA--SNINFSWKC-------- 761  Tetrahymena t...
XP_001627539 2168 TKSITLNVESSPLVARIRGGATKVVGA-TS-TMTMDASP--SIDP-D--------K--TSE--TAW-YRWECFDSS---- 2225 starlet sea a...
NP_001075434 2084 ETSILVTTHQSDLFAKIDGATEFTVGR-DSgTITLVGTN--SIDP-D--------EQ---A--RDWEYVWLCEQTDdns- 2145 purple sea ur...
NP_001075437 2420 TQTVTITTVYTDLDALIDGGSERTIGVdSE-SFTLDGSS--SFDP-D--------RENEE-----MTYLWTCRKSNte-- 2480 purple sea ur...

A0FEM3       1661 -----------------qewNEDYTTLLNDGYNAKdpyivepndyggcfgrfgfdkggmGSILNFTEGSFTLDTFYMHEN 1723 purple sea ur...
A0FEM4       1615 --------------------NGVTPVPTVDPTNESiceys---------------kadeHTVTGETKSLFTIGAPRLALD 1659 purple sea ur...
A0FEM5       2188 -----------------ssaNEEESTPATRPTTTT------------------------TSSGSPTTRSSTTTPQSPGDN 2226 purple sea ur...
Q4T3T9        770 ------------------------VALSVTPSQSS---------------------------------SVDSVNNVTVKR 792  spotted green...
Q8MVW7       1421 avsvtvkvtavaqpisvsfsVPDMTQSKDDPVAFSinvkdpsstsds-ltlsstcvdstGTACSSNPGSTSSFSSSFTAG 1499 Naegleria gru...
Q54XQ9       1263 ------------------------------GKDCG--------------------------LNLESEPIITFNSSRLNVG 1286 Dictyostelium...
Q229K3        762 -----------------------NSLYSNDHICYDyq--------------------nnQIQLQQGVSSIKFPAKTFQPY 798  Tetrahymena t...
XP_001627539 2226 ----------------------ENPCFRPDPVNAGrq--------------------irVTFPTTAQVSFSV-ADYLSSN 2262 starlet sea a...
NP_001075434 2146 -----------------acwSYDPDALGTLIINDS----------------------------NSGMGELEFDAQALEAD 2180 purple sea ur...
NP_001075437 2481 ------------------tgSYEPCVSSETREVFP-------------------------AEADSKTSTLTLTSNNLYSD 2517 purple sea ur...

A0FEM3       1724 MTYFLKLIAFKGD-----R-MAIATQEMQVASGNPPKMAIACRTNCKTKLNPTSRF--ALE------SADLD----ARkG 1785 purple sea ur...
A0FEM4       1660 ATYTIKVTANHAD-----GrLGSYEQAITTVPGYPVQAKIDCIQNCLKKVNPTSLV--AYQa----sCLNCA-------T 1721 purple sea ur...
A0FEM5       2227 GNNDDGSSIQEG------DdSLFEDYSSDVYEGGDSSLQSSEADGDGVANPNNPT------------------------T 2276 purple sea ur...
Q4T3T9        793 RTLTVKNLMREDAasqwlMnKSQTELRAVVQHGNPQEIIPYAIALTSRLNQAVPSel---------tCEDCQ----KKvL 859  spotted green...
Q8MVW7       1500 -TYIFTTTATKGS-----RtASSTLKVTVIDTSKDKIVRVSITSNADLTTVDPTRD--LYLty---nSLDA--------L 1560 Naegleria gru...
Q54XQ9       1287 V-FHFSVDVTPNGd---aTrSGSASATVTIVNTPVIDVIISPLPT---TIDPTQKL--VLYtv---vSGNDA----S--S 1348 Dictyostelium...
Q229K3        799 TAIQITVVGQKDS-----RqSNFTTICIFTELDIPPLNILLTATSINRKINLNDDL--NFQin---yGENVS----SDyL 864  Tetrahymena t...
XP_001627539 2263 QQYKFKMTFNKGS-----R-SDSTEMTVIVKAGDPPRVTIRPQTNSKENPSDVVKI--KALasstlpSTNVT----WE-S 2329 starlet sea a...
NP_001075434 2181 KTYQFSLTVRKET-----R-TAQTFVTILAVNGNPPKIILTTNDEDGVINDDVPLEltAYIf----hSSDLSnvdwAT-V 2249 purple sea ur...
NP_001075437 2518 STYLFTLEINKLS-----R-TASTSVTILSKSGNPPTISLDESLPEKIKSSSSHTL--RVLi--------------SH-T 2574 purple sea ur...

A0FEM3       1786 -QILY-YRWeifkqeynpvSLENEFVIVPKTqWL-QFAGTGDSNTN----I-----AIDA---GPFEDQSTYRIRV---Y 1847 purple sea ur...
A0FEM4       1722 -QNAT-FRWem------kiGMETRE----EEdLA-AKADTDLTKSG----L-----VIRA---NVLESGKFYYVRV---Y 1773 purple sea ur...
A0FEM5       2277 -NEEHi------------vSRSSQAVVISED-----STLSGLKGKQ----F-----TLRP---GILEEGRTYAVGVk--I 2324 purple sea ur...
Q4T3T9        860 -ETAG----------------------KLIHvLE-EQASPGVL-------S-----AVKT---GVALSAVDLAGILmrsV 900  spotted green...
Q8MVW7       1561 -SSPT-FTW------------------------T-SESGDTSSSSL----L-----VISK---SNLVPGASYAVTL---- 1597 Naegleria gru...
Q54XQ9       1349 -SNLT-YEWn--------mLEGTLE--LPLKqAY-STPMNSRN-------L-----VLKA---GALGSKVVYRFSVd--V 1398 Dictyostelium...
Q229K3        865 -SYAGaILY------------------------N-NNPVAAIKFDY----F-----QVRFrvwNYFQKILPSNPTLqirF 909  Tetrahymena t...
XP_001627539 2330 vEEDG-FAYl---------DLSTAGTILTPLqFT-FEKASGRAKATrgcaL-----VIAK---DKLSGGVQYKFRL---- 2386 starlet sea a...
NP_001075434 2250 -DTTS-GYSy---------IDLTDSDNLLGD-AQlLETGDGLSIAT----I-----TIDR---DIVQRGASYAFSLn--V 2303 purple sea ur...
NP_001075437 2575 -SDIT-IDWatf-----diDLGYGYVDFSQLnSQ-SFLIQGDTSPF----ItyafvTIPT---GTLEEDVAYSFSVt--V 2637 purple sea ur...

A0FEM3       1848 AARTPSLQnyGLASYDFITNERPTVGNCSA----VPPNGTALETEFNI---EC-QDW--TD--PD-M----PLNYRY--- 1907 purple sea ur...
A0FEM4       1774 VEEPGLLE--GFTEVYFYTNLPPFGGNCNI----EPRTGTALNTDFTA---TC-KDWkdEG--DEaEftddPLPYVPllr 1841 purple sea ur...
A0FEM5       2325 YPEDGSAGvrAEAFQYVTVNEAPKLGICSI----SPDSGTELDTIFSA---AC-HSW--ND--ED-T----PLQYEV--- 2384 purple sea ur...
Q4T3T9        901 MRLRGPQQapVLLSAPHINTVGFRGDPAHL----LCTNH--LQSSTSV---PC--------------------------- 944  spotted green...
Q8MVW7       1598 SVVDGAKS--GSASVSFTVNSPPTKGTFEA----YPTSGVALSDLFDL---KCgNGW--SD--PQ-T----PLKFQF--- 1656 Naegleria gru...
Q54XQ9       1399 KNKKTGAT--GKAMVTFTTEAIPQGGDITC----LTTSG-DVTDTYSI---TMgDQW--TD--NSgI-----KSYNF--- 1456 Dictyostelium...
Q229K3        910 SVYNPLYImpSLSTISIQINIPPQNCVLSI----NPKEGIALETIFQIqllNC------TD--ED-L----PLTYQFfyy 972  Tetrahymena t...
XP_001627539 2387 TAKHRDSD--AYGDAVIRTNAAPSQGALTV----SPSNGTSMETVFTV---TArEGW--SDdaDD-L----PLNYQFg-- 2448 starlet sea a...
NP_001075434 2304 TDIDDQYS---TVKSYVVVRSGPTSCEFSV----PSYEELDEVTFTTE---NC-VTS--AD--A--Y----PLNYQL--- 2359 purple sea ur...
NP_001075437 2638 TDTEGQVS--A-SKLTTSTYGGVSSCTFSLgdgsTSYQELDEITLLTQ---NC-VT---DE--EA-Y----PLSYQV--- 2697 purple sea ur...

A0FEM3       1908 ----AQRLQESEsWTWLYNGERAf---MDTPTVFPQGYEEN-N--FQV-FLLVRVTDYIGSFS-DLLLTVEVRPPSVSNA 1975 purple sea ur...
A0FEM4       1842 yriqYRPQGEEAySQLVPAGETG----IIKQLKFSIGPEAF-N--YTF-EILFTVLDKFGGMD-QANTTIQVIPGVATKE 1912 purple sea ur...
A0FEM5       2385 ----RYSLNQSDpETILYYGMDR-----SVRFLLPAGHAEN-H--HNV-YLKLAIVDNKGGKTsVCDIAIPVSPKPFESP 2451 purple sea ur...
Q4T3T9        945 ------------------------------QFYIPPYFTAHlK--SQKsEVVQVLLDTDSKLV-SNPLATAADPPISTTL 991  spotted green...
Q8MVW7       1657 ----FFYDSANVkWNPLTEKTEQ----QSAKVLLPQPAS---G--SVL-MVKAVVYDSLGAST-ETQTNITITKPSVAAA 1721 Naegleria gru...
Q54XQ9       1457 -----RYRVGSGpAIALSESSSD----NSISTILPPGQI----------TIIGYVTSNDGITA-SKSCKIQVKEASNIEE 1516 Dictyostelium...
Q229K3        973 nsadDALQELISpWNILRRQIQDqtinNSIQTVLPQGNL----------VFMVQVMDSYLGVY-NTSSTIQVQAQNKSAD 1041 Tetrahymena t...
XP_001627539 2449 ---yIDPRTNKEeLQGMFGGSNQ----REI--KFPPGDENN-A--RSL-TVFVNVKDQLGAVT-RQTATITVMPVAVTTA 2514 starlet sea a...
NP_001075434 2360 -----SVVKADGeLEIITE---R----NSEPSFTGVGKPKL-EgsDNR-TYIITVCDKNEMCA-TWIAGTNVSLKLSFSA 2424 purple sea ur...
NP_001075437 2698 ------FREKVEsSVTRYNAMTGa---LAEASSTILGLPSFsD--NQN-TFVVKVCNDFGSCS-SYSLTLDVTPIASFSQ 2764 purple sea ur...

A0FEM3       1976 e--qMEMMQNMTGDDGVMSAAIANGDTSTAANIIAA 2009 purple sea urchin
A0FEM4       1913 ------GLVDLFGTGGDIDTFLQSKDPEAGMRYLSA 1942 purple sea urchin
A0FEM5       2452 enklEYLEAVSVGRDSMLAVYVAHGDDLNVHSHVRL 2487 purple sea urchin
Q4T3T9        992 -------VAMELSTPQGKPIAVQHLDPEQAIRVTLP 1020 spotted green pufferfish
Q8MVW7       1722 --------------TSALSAIASGKDTVTLAAASSA 1743 Naegleria gruberi
Q54XQ9       1517 -------------AINFLSTTITNPDV-SLYQLSVA 1538 Dictyostelium discoideum AX4
Q229K3       1042 --------EYYKLVNQHTLQALQSSNMQISNQLVTl 1069 Tetrahymena thermophila SB210
XP_001627539 2515 ---------FLDNAKDDILKSFESADWNSALGNMGA 2541 starlet sea anemone
NP_001075434 2425 -------ADINSFKADFVNAKTFGGDHIGALANRNM 2453 purple sea urchin
NP_001075437 2765 ----EQ---FDESITNLVEPQKLSGNFLDALVNFNT 2793 purple sea urchin
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