4JFN


Conserved Protein Domain Family
APP_N
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pfam02177: APP_N (this model, PSSM-Id:280358 is obsolete and has been replaced by 460474)
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Amyloid A4 N-terminal heparin-binding
This N-terminal domain of APP, amyloid precursor protein, is the heparin-binding domain of the protein. this region is also responsible for stimulation of neurite outgrowth. The structure reveals both a highly charged basic surface that may interact with glycosaminoglycans in the brain and an abutting hydrophobic surface that is proposed to play an important functional role such as in dimerization or ligand-binding. Structural similarities with cysteine-rich growth factors, taken together with its known growth-promoting properties, suggest the APP N-terminal domain could function as a growth factor in vivo.
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Statistics
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PSSM-Id: 280358
Aligned: 23 rows
Threshold Bit Score: 163.604
Created: 9-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4JFN_A         9 EPQIAMFCG----RL---N------------MHMNvQNGKWDSDPSGT---KTCIDTKEGILQYCQEVYPELQITNVVEA 66  human
XP_003377852  30 VPQVVFRCG----FR---N------------RYMT-EDGSWASDPDSR---ASCLTGKLDILKYCRKVYWNLTVTNIVES 86  Trichinella spi...
XP_001899252  41 VPLVAFQCG----FR---N------------RFMS-EDGAWLSDPSTL---ATCFSGKLDILKYCRKSYPKLDVTNIVEY 97  Brugia malayi
CAP33080      35 iPMVAFSCG----YR---N------------QYMT-EEGTWKTDDERY---ATCFSGKLDILKYCRKAYPTMNITNIVEY 91  Caenorhabditis ...
ERG82727      18 VPLVAFECG----FR---N------------KFMA-EDGTWVNDVNRY---ATCQSGKLDILKYCRKAYPKLDITNIVEY 74  pig roundworm
XP_002426949  17 EPQVAILCE----SG---SgseqqktqayhsQYMT-EQGKWITDINNK---ATCLKDKMDILDYCKKVYPKRDVTNIVEA 85  human body louse
XP_002400743  11 QPMVALLCG----HGrinN------------QYLA-EGQRWVSDPDPK---AVCSKDKLSILEYCRKVYPKRDIRNIVES 70  black-legged tick
XP_008209440  46 EPQVATLCEagevYL---A------------QHMG-EQGRWISSSDTK----SCMTDKLEILQYCKKAYPKRDITNIVES 105 jewel wasp
EFX86398      42 EPQVAVVCD----LR---Npl--------hpQYMD-STGKWVSDLENK---SYCLKDKIEILDFCRKVYRGRNITNIVEA 102 common water flea
XP_002055698  32 EPQIAVLCEagqiYQ---P------------QYLS-EEGRWVTDLSKKttgATCLRDKMDLLDYCKKAYPNRDITNIVES 95  Drosophila virilis

4JFN_A        67 NQPVTIQNWCKRG---RKQCKT-HpHFVIPYRCLVGEFVSDALLVPD 109 human
XP_003377852  87 SHFVEVDNWCKDD---GYPCKW-S-FWVKPYRCMVGEFESDALLVPk 128 Trichinella spiralis
XP_001899252  98 SHEVEIPGWCREQ---GSSCRW-T-HTVRPYQCIVGEFHSEALQVPH 139 Brugia malayi
CAP33080      92 SHEVSISDWCREE---GSPCKW-T-HSVRPYHCIDGEFHSEALQVPH 133 Caenorhabditis briggsae
ERG82727      75 SHETKIASWCREE---GKPCKW-T-HTVRPYQCIVGEFHSEALQVPH 116 pig roundworm
XP_002426949  86 SHYLKVPNWCKVG---HKKCKI-S-RWVKPFRCLEGPFQSDALLVPE 127 human body louse
XP_002400743  71 SRYYHVDGWCKVGq-rGRSCRG-S-HWVKPYRCLEGDFQSDALLVPE 114 black-legged tick
XP_008209440 106 SHYVRVSGWCKPG---KNKCKL-S-RWVKPYRCLEGPFQSDALLVPE 147 jewel wasp
EFX86398     103 PRSVKIDNWCKLG---HRKCKT-T-QSVKPYRCL-GAFQSEALLVPE 143 common water flea
XP_002055698  96 SHYQKIGGWCRQGslnAAKCKGaH-RWIKPFRCLEGPFQSDALLVPE 141 Drosophila virilis
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