Conserved Protein Domain Family
Reticulon
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pfam02453: Reticulon (this model, PSSM-Id:280592 is obsolete and has been replaced by 460562)
Reticulon
Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologues.
Links
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Statistics
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PSSM-Id: 280592
Aligned: 241 rows
Threshold Bit Score: 77.897
Created: 9-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O82352        68 PADVFLWRDKKLSGAVLGVATAIWVLFELVeyHLLSLLCHISILALGGLFLWSNAHTLIN-----KT-S-----PQ---- 132 thale cress
Q4G5K8         5 VMDLVYWKDMERTGMVLTGLVVALLSLFQL--SIITVVSTLSLAILCFTISVRIYYKLLH-----VLqL-----GD---- 68  zebrafish
Q4G5T7         5 VLDLIYWRNLATTGVVFTGLVVGLASLFQL--SAITILSNLGLSIMAFTLPVRLLYKAMT-----VTrL-----ND---- 68  zebrafish
XP_005804210 289 VMDLIYWKDTERSGLVLTALVVGLLSLFQL--SIISVVSTVSLAVMCFTISVRIYYQFLH-----IL-SwgdgeHP---- 356 southern platyfish
CCD75067      23 VRSIVYWRQPIVTGVILTLLLIVEFSFMCL--SAISFIAYIGLALLVSVNLLRMYYHFVA-----KT-E-----NNfvre 89  Schistosoma man...
GAA34055      20 VRSLIYWQDPIHSAAVLAVLLAAQFGFLYL--SAISFVAYTGFFLLLSVNLCRLYYHYIA-----KT-E-----SQfikd 86  Clonorchis sine...
CDJ02070      26 VISLIYWKKPVESAIVMATGFTLLFSIGCL--SLISVFAYVCLAILCCTGAARVYYDLITskrdeTA-S-----PPfsd- 96  Echinococcus mu...
XP_007250086   5 VADLLYWRDVTKTGLVFTGLVVGLASLFQL--SAISVLSNLGLGIMFFTLFVRLTYRSMD-----LV-R-----LN---- 67  Mexican tetra
XP_004076547   5 lvDLVYWRSMRRTGVVFTGLVIGLASIFQL--SAITVLSHVCLGILCITFPLRLYYKLLE-----LL-R-----WN---- 67  Japanese medaka
NP_001033317   5 LMDLVYWRDVRKTGVVFTGLVISLASVFQL--SVITVFSHICLVAMCATFPLRLYYKLLE-----LLrW-----NP---- 68  torafugu

O82352       133 --I----------P-----EIHVPEEAFLVVASSLRNELNQAFVILRSIALGRDLKKFLMVVVGLWIISVVGNWFNFLTL 195 thale cress
Q4G5K8        69 --Gvhpfq-syldL-----DISLSGEEAEHCLQRAIVLSCSALETLRNLIFVGNLFSSLKFWLLMYVVTFLGNLCNGLTL 140 zebrafish
Q4G5T7        69 --Gshpfq-syldE-----DHTLTDEDTVRMAEQMVLLIATAVSELKRLFFIDSIMDSVKFIVFLYLLTYVGVQANGLTL 140 zebrafish
XP_005804210 357 --F----------KsyldlDISLSGEQADIYMKKAISLALSAVDTLRRLFFVENLFESLKFLFLMYLVTYLGGLCNGLTI 424 southern platyfish
CCD75067      90 ylE----------R-----EITVPQDKAEKVSRRLTEVLNKGLIRTREIFLLTDPAASVKFAVLLYLLTYIGAQFNFLTL 154 Schistosoma man...
GAA34055      87 ylE----------R-----DVSLPKDQMADVARRLTDHANEVIMQARDVFLLTNIGASVKFGVLLYLMTYVGARFNLLTL 151 Clonorchis sine...
CDJ02070      97 wfI----------K-----DKEALRQRVHDYVNEKFDKTESAFQDLRHYLLIENYIDSMKFALLMYLLSILGGFFNLITL 161 Echinococcus mu...
XP_007250086  68 --DgthpfqsyldE-----DSTLTDEDTIRVVEKIVLLIATLITELKRLIFIDSTVDSLKFTFLLYLLTYVGLQTNGLTL 140 Mexican tetra
XP_004076547  68 --PgihpfqsyldY-----DVSLTDKDTVMLVEEVVLLVAFAVTEIKRLLFIDNLIDSIKFVLLLYLLTYVGTVTNGLTL 140 Japanese medaka
NP_001033317  69 --Gvhpyq-syldY-----DSSLTDRETVMLVEEVVLLITFAITELKRLIFIGSITDSIKFVVLLYLLTYVGALTNGLTL 140 torafugu

O82352       196 VYICFVILHTVPMLYEKHEDKVDPLAEKA 224 thale cress
Q4G5K8       141 IIIGVIAVFSVPLFYTRHQDKVDSCIVAV 169 zebrafish
Q4G5T7       141 VMSGVICAFSLPLLYKLQQERIDKIIKAV 169 zebrafish
XP_005804210 425 LIISVIALFSLPLFYEKRQEQVNGFIGKI 453 southern platyfish
CCD75067     155 CILFTFGVFCVPKFYERYQPEIDKMIELA 183 Schistosoma mansoni
GAA34055     152 CITGTVLAFFLPKFYKTYQDEIDRALSvf 180 Clonorchis sinensis
CDJ02070     162 VLLAFTLIFTIPMIYDLYHVQIDKFTEKp 190 Echinococcus multilocularis
XP_007250086 141 LISGVICAFSLPLAYKLQQARVDKIISVV 169 Mexican tetra
XP_004076547 141 MIAAVIGVFSLPLLYKKQQVRIRRMARtf 169 Japanese medaka
NP_001033317 141 VISAVIGLFSIPLLYKKQQVRLRRTVrtv 169 torafugu
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