4RG1


Conserved Protein Domain Family
Methyltrn_RNA_3
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pfam02598: Methyltrn_RNA_3 (this model, PSSM-Id:280718 is obsolete and has been replaced by 460611)
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Putative RNA methyltransferase
This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA, and may function as a methyltransferase.
Links
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Statistics
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PSSM-Id: 280718
Aligned: 167 rows
Threshold Bit Score: 191.196
Created: 22-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4RG1_A        12 LSVALPGSILDNAQSPELRTYLAGQIARACAIFCVDEIVVFDEEGQDAkTvegeftgvgKkgqACVQLARILQYLECPQY 91  human
WP_013304294  17 ISIAIPSSIVSESPDPREKVRKIGYIGRASAIFRVEEIFIYMDDSEENlN----------------YIYELLSYLEIPPY 80  Ignisphaera agg...
WP_008526526   3 qSALVPSSLCREAEDKREATRKIGYVARAATVFRVDRLIVYPDPDGAgr-------------wGDGFVETVLRYAATPPY 69  Halorhabdus tia...
WP_015762783   3 tSVLVPSSLVREAEDRREATRKLGYVARAAVVFRVDRLTIFPDPAGAGkW---------Ed----gFVETVLRYAATPPY 69  Halomicrobium m...
WP_020447059   3 VSVLVPSSLAREAEDKREATRKLGYVARAATIYRVDRLVVFDDPAGETgS---------M---DGGFVRTVLRYAATPPY 70  Salinarchaeum s...
WP_014027192  14 LEIVVPASVLSVEPSLQLKTVKAGVIGRAAAVFRASRIVLYVDRAEAWr--------------DLETFRKLLEYLATPPY 79  Pyrolobus fumarii
WP_014557663   4 IEILLPYCSLENEPDQIRITLKANIIARAASIFKVERITLYR--SRSDkK---------SckdQKEILGLLLRYFVTPPY 72  Fervidicoccus f...
WP_011839304   7 ilVALPTSILSTESSLLLKTIKTYQVIRYSSIFGVSEIVFFRDPFTDFsQ---------Hrk-ySVLIEKIWRYLLTPPY 76  Staphylothermus...
WP_012608845   6 LSIVLPTSILSVEPTLFLKSLRIHQVARWSSIFGVNRVVFYREYETSr-D---------EfreHREIISIHWRYFFTPPY 75  Desulfurococcus...
WP_014736998   5 VHVVLPSSVLTVEPPGLSRLLKAYQILRYTSIFGVEKAVFFKDFSTSErD---------Hg-tARAFIEKVWNYYKTPPY 74  Thermogladius c...

4RG1_A        92 LRKAFF-PKHQDLQFAGLLNPL--Dsp--hhMRQDE-ESEFREG-IVVDRp------TRpghgSFVNCGmKKEVkI--D- 155 human
WP_013304294  81 LRRKLV-PYKPSLRYVGLLPPL--Ktp--hhVRREIfNTNLREG-VVID---------SndirSIIDIGlDKKGvA--Y- 142 Ignisphaera agg...
WP_008526526  70 LRKEVW-DRRDELECVGVLPPL--RvatqtgSGSDD-SGSLRQG-IVTEVgs----dGRv----RVNCGmQHPIsL--Av 134 Halorhabdus tia...
WP_015762783  70 LRKEVW-GKRDELEYVGVLPPLrvRsq--tgSGSEG-SGSLRQG-IVTEVga----dGRv----RVNCGlQHPIsL--P- 133 Halomicrobium m...
WP_020447059  71 LRKEAW-GERDELEYAGVLPPL--HassrtgSGSSG-PGSLRQG-IVTEVgp----dGRv----RVNCGvQHPIsL--Pv 135 Salinarchaeum s...
WP_014027192  80 LRKRVYpPGVPELRYAGLLPPL--Qipt-hgVGGPK-EGEIREA-YVLRKrg---------rsVVVDAGlEEEVeV--D- 142 Pyrolobus fumarii
WP_014557663  73 LKKKIF-GKRKELKYVGMAYPL--QipthslSKKAK-EGDIRVG-LVERVke----sAI-----FADIGvGKQVkIsnS- 137 Fervidicoccus f...
WP_011839304  77 LRRKLI-PKDPDLKFVGLLPPL--RlstfdvSRNGR-VGEKRLG-LIYREkn----kL------LADIGlPRPYrI--E- 138 Staphylothermus...
WP_012608845  76 LRRRLV-PRNPLLRYVGALPPI--Rlse-fnVSGKPvDGEERIGfITLEEgkltaylDNvekySLVN------------- 138 Desulfurococcus...
WP_014736998  75 LRRKLI-PIDRDLRGVGILPPL--RlesfhvSKRPY-TGQVRPA-LVKRSad----------gCFADIGvGEDFaV--Eg 137 Thermogladius c...

4RG1_A       156 --K----NLE-PGLRVTVRLnqqqhpdcktYHGKVV-SSQDPrtka----glywGYTVRLAsCLSAVFAEApfqdGYDLT 223 human
WP_013304294 143 --Gr---YIP-RGSRVTVKIvr------eqRDVYIV-DIVDEkeid-----iywGYKVYRFkSMKEML-EYsiknSY-IV 202 Ignisphaera agg...
WP_008526526 135 pgDr---TIR-EGERVTVRIssr-----rpVRAKIV-DQPPP------------GYQVDRAn-LDAALSRP----DAGVR 187 Halorhabdus tia...
WP_015762783 134 --VpsamEVPgEGERVTVRVssr-----rpVRAKLV-D--EPl----------tGYVVDTAd-VDTALERS----DAGFA 188 Halomicrobium m...
WP_020447059 136 phEr---DIG-EGERVTVRVssr-----rpVRAKIV-DEPLP------------GFEVDRAd-LPTAIEDSr----nTCR 188 Salinarchaeum s...
WP_014027192 143 --LprgvQVN-RGERILV---------------KIV-SLTPPileyvenppvytGYRVATFdSLGDYL-RSar--kdTLL 200 Pyrolobus fumarii
WP_014557663 138 --Ny---ELK-RGDLIFVKVkkg-----dlSELEIIkNPDiy-----------vGYSVRECeNPLDYLKEk---kKDGLV 192 Fervidicoccus f...
WP_011839304 139 --Ag---NCK-PGDIGYVEIvdv-----ntRRAICL-D-VEPy----------rGPILAFAdSLQEVLEEyr--kTVDLI 193 Staphylothermus...
WP_012608845 139 -----------PGDCkq-----------gfSRVKVV-DSRRKlaecid-teyyiGPSLVFRnSLREALDEAge---kvFI 191 Desulfurococcus...
WP_014736998 138 -------ECR-EGVR----------------QVRVV-DPVKKvvelte-tklytGPETAFKnSLREVLEEYa---GKSFL 188 Thermogladius c...

4RG1_A       224 IGTSer-gsDV-AS-----AQ-L-P-N-FRHALVVFGG-L-Q-G-LEAGAdadp-----------------------nle 265 human
WP_013304294 203 IGASkk-gqPL-YCleseiKD-I-L-SgDKRIVIVFGG-P-RlD-IDEIAvn---------------------------e 247 Ignisphaera agg...
WP_008526526 188 IAASrh-gqSLtTErlgrlVGtI-A-S-AGDMTVAFGA-PeR-G-LPAILgvepgavdpctvdelaaavdaaerndetvt 260 Halorhabdus tia...
WP_015762783 189 IAASrh-geELgVDrlgqlVE-R-RdD-AGHMTVAFGA-PeR-G-LPAIFgldpdda-----------------vpdgtg 244 Halomicrobium m...
WP_020447059 189 IAASrh-gtPLtATrltdlVG-H-L-Q-TEGLTLALGA-PeR-G-LPEILdvda-----------------------dsv 237 Salinarchaeum s...
WP_014027192 201 IATSrr-grRI-DEvvdelRK-K-LgE-KKRVALLFGS-P-ReG-LYEIAer---------------------------e 245 Pyrolobus fumarii
WP_014557663 193 IGTSkf-gdPI-WEnlkevEE-KlK-S-SDKVVVVFGEpY-R-G-IFEIFkq---------------------------l 237 Fervidicoccus f...
WP_011839304 194 IATSkygkiPS-HKelagvKG--------KTIIILFGG-PhR-G-LYDIAkke--------------------------- 234 Staphylothermus...
WP_012608845 192 IATDkt----geAPslsnlAS-L-K-G-RMELMLLFGS-PeR-D-LFEISrg---------------------------e 233 Desulfurococcus...
WP_014736998 189 LATDrr-grVP-SLvt--daK-R-M-S-GKKVVVLLGS-P-S-HdLFEMSva---------------------------e 230 Thermogladius c...

4RG1_A       266 VAEPS-VL------------------FDLYVNTcpgqgSRTIRTEEAILISLAAL 301 human
WP_013304294 248 GIDIY-RY------------------SRYIINFiprqgVESVRTEEAIFAVLSLi 283 Ignisphaera aggregans
WP_008526526 261 GSGSDgPR------------------FDLWLNTvpnqgSEVVRTEEAMFATLGPL 297 Halorhabdus tiamatea
WP_015762783 245 DDDAG---------------------FDLWLNTvpnqgSEVVRTEEAMFATLASL 278 Halomicrobium mukohataei
WP_020447059 238 DDSPS-ALrraiessgdadvdptpggFDCWLNTipnqgSETVRTEEALFASLAtc 291 Salinarchaeum sp. Harcht-Bsk1
WP_014027192 246 GIKLD-ES------------------VDAVVNVvpnqgTLTVRTEEAVWAALSLL 281 Pyrolobus fumarii
WP_014557663 238 GGNTD-DL------------------FHGIYNLvrdqgTKTIRMEEALFIALSLL 273 Fervidicoccus fontis
WP_011839304 235 gfiLE-NK------------------VDKVWNTipeqmVKTIRSEEALISTLAvv 270 Staphylothermus marinus
WP_012608845 234 GFNLL-EY------------------VDAVWNTvpgqhVVSVRTEEAVIITLGLL 269 Desulfurococcus kamchatkensis
WP_014736998 231 GFNLR-MF------------------VDDVWNTipgqkVVTVRTEEALIITLGIV 266 Thermogladius cellulolyticus
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