2DWK


Conserved Protein Domain Family
RUN

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pfam02759: RUN (this model, PSSM-Id:280855 is obsolete and has been replaced by 397055)
Click on image for an interactive view with Cn3D
RUN domain
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.
Statistics
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PSSM-Id: 280855
View PSSM: pfam02759
Aligned: 41 rows
Threshold Bit Score: 92.3036
Threshold Setting Gi: 296452974
Created: 11-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DWK_A         46 QFFVVXEHCLKHGLKAKKT------------------------------------------------FLGQNKSFWGPLE 77   house mouse
Q6NXD8       1163 GLVWALEQFFHHGFRsa-------------------------------------------------rIFQKNVFVWDFFE 1193 zebrafish
Q54LN3       1015 RLATAIANLVSHGFIVSPTnmvgsifrnvingatgs--------------ggggsgggnslssslgnIVTGKRHLWEFIE 1080 Dictyostelium...
Q94222        607 RLANSFRQIMDHGIRENALytsmayhp--------------------------------wsfiediaYYSVEKNFNSVYS 654  Caenorhabditi...
Q17FM5        615 TLAPTIKQVLEHGMKRPSFlggpchpw---------------------------------lfieeaaTREVEKDFESVYS 661  yellow fever ...
Q96C34        429 ELTVAVRDLLAHGLYASSPgmslvmapiacllpafs---------------sapeamhpwelfvkyyHAKNGRAYVESPA 493  human
Q9W5C1        516 NFARTLQQLIQHGLRIPAEsaasslmvpfmrclhpgppvvppavggdsqflglgramhawelvlayyRLKHGEEYNNTPA 595  fruit fly
XP_012314452  564 TLCPALKALFEHGLKKPSLlggachpw---------------------------------lfieeaaGREVERDFASVYS 610  Ma's night mo...
CAF87805       39 ELAPALKDLLAHGLFSPSQtmslvlapiscllphq----------------papqalhpwdlfvkyyHSKNGRAFVESPA 102  spotted green...
CAG11848       44 CLCPALHSLLTDGLKPHQSdl---------------------------------------------iAGRRPNSAWGLVQ 78   spotted green...
2DWK_A         78 LV-----------------EKLVPEaaEI---TASVKDLPGLKTp----------VGRGRAWLRLALXQKKLSEYXKALI 127  house mouse
Q6NXD8       1194 RIvafmenrdqtgdlqespEPLSLNseSL---CRYVNAINNMPRni-------gkDGKFQLLVCLGARDRLLPQWLPLLA 1263 zebrafish
Q54LN3       1081 NY-----------------KKTTQHgtIAg--ISLIQTINTINSfenissawkdpNIKFRTLICVGLNQHVLDQWFALLQ 1141 Dictyostelium...
Q94222        655 RLtlcntf------nldedGKILTPeeLL---FRSVQLINDSHNavs-----ahsDVKLRSLLVVGVNEQCIHLWFDLLC 720  Caenorhabditi...
Q17FM5        662 RLvlckty------rldedGKVLTPeeLL---YRCVQAVNQSHDaah-----aqmDVKLRSLICLGLNEQVLHLWMEVLC 727  yellow fever ...
Q96C34        494 RKlsqsfa------lpvtgGTVVTPkqSL---LTAIHMVLTEHDpfk-----rsaDSELKALVCMALNEQRLVSWVNLIC 559  human
Q9W5C1        596 RKlsqsfq------ldivdAQAVTAkqSL---LSAVGMILAMHRpyk-----rsnNAHFKAFVCAGLNSHLLVEWLNLIL 661  fruit fly
XP_012314452  611 RLvlcktf------rldedGKVLTPeeLL---YRAVQSVNVTHDavh-----aqmDVKLRSLICVGLNEQVLHLWLEVLC 676  Ma's night mo...
CAF87805      103 RQlsqsfs-----lpvggaAVTVTPkqSL---LWAIHSVLKEHGryk-----rgpDTKFKALVCMALNEQRLVSWLNLLC 169  spotted green...
CAG11848       79 AS-----------------TRPGPKtqILfnlQVRVSELPQLRHs----------KQRFNAFLLGLLNTKFLDFWLSHLH 131  spotted green...
2DWK_A        128 NKKE---LLSEFYEVNALXXEEEGA------II-AGLLVGLNVIDANFCXKG 169  house mouse
Q6NXD8       1264 ESP----VITRMYEENALLRDKLTVs-----SL-LGVLETLHDFPITLETSL 1305 zebrafish
Q54LN3       1142 TDTN---GISHYFHPNAIINSLDHWr-----LF-CQCFAPILNLPFKLSLDY 1184 Dictyostelium discoideum AX4
Q94222        721 SATQhehIRNKYYHSWAFIRSPAWR------QI-KCDLRLLSQFSFNLSMSF 765  Caenorhabditis elegans
Q17FM5        728 SCSE---IVHKWYQPWSFIYSPGWV------QI-KCELRLLSQFAFNLNPDW 769  yellow fever mosquito
Q96C34        560 KSGS---LIEPHYQPWSYMAHTGFE------SA-LNLLSRLSSLKFSLPVDL 601  human
Q9W5C1        662 SCHE---LVDTYYSADSYVARTGFR------DS-LRSIDALSRFDFDLPVDL 703  fruit fly
XP_012314452  677 SSLP---TVEKWYQPWSFLRSPGWV------QI-KCELRVLCCFAFSLSQDW 718  Ma's night monkey
CAF87805      170 KSG----TLVDHYQAWSYMAQTGFE-------GaLRILGRTSHLKFSLPVDl 210  spotted green pufferfish
CAG11848      132 SCTD---VLETYYQPASFMRLSLTAcrplfeEL-LLVLQPLSLLTFNLDLlf 179  spotted green pufferfish
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