Conserved Protein Domain Family
CD20

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pfam04103: CD20 (this model, PSSM-Id:282023 is obsolete and has been replaced by 397979)
CD20-like family
This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.
Statistics
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PSSM-Id: 282023
View PSSM: pfam04103
Aligned: 43 rows
Threshold Bit Score: 48.4125
Threshold Setting Gi: 75045739
Created: 24-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P19437        44 ALGAV---QIMNGLFHITLGGLLMIPTGVfapICLSVWYPLWGGIMYIISGSLLaAAAEKTSR----KS--LVKAKVIMS 114 house mouse
Q95PZ5        94 RLCLV---ELMLAVVILGGGIWCYRDTSD----YCPYYSAIWTSAIYIINAIVG-SAAAKMGA----LN--LYMAHLTLS 159 Caenorhabditis ...
Q3TRE0        28 lLALL---QLALGIAVTVLGFLMASISPS----LLVRDTPFWAGIIVCVVAYLG-LFMLCVSYq--vDE--RTCVQFSMK 95  house mouse
Q1LVQ8        42 LVALL---QLLLGIAVAAVAFLMLAISSS----LLARETPHWAGIIMCVVSLLG-FVLFCITRvpdeR----ALLQFVIK 109 zebrafish
Q08BU9        43 SIGVV---LSMMGVGLFLFGIPMTVHTDIm--TSADVFSPFWLGILFCVCGVLY-ILSERSPS----KK--IITASFALS 110 zebrafish
Q5BLA7        16 VLGIL---QVACAGLCVVCGFMDAVFRKSt--TLSETRAPLWAGLIMAAPGVLA-LFASQKKN----PY--LVNVMIVSS 83  zebrafish
XP_001633519  20 gfGVV---QVILGLSLTGLSFAAFALSES---DRIRNACPYWAGFTVFFSGGVG-IVAWRHST----IL--SMGLFTFFS 86  starlet sea ane...
XP_001626281   7 LLGIIssfHLVFGVFSVVLGIVTFKVAPY---FYGVFGMGIWLGAWMLITGVAGlLTASVPTN----MC--RLGSFIGCS 77  starlet sea ane...
AAI55057      48 SIGVV---LVMMGVCLFMFGIPMT-TPKD---MMTDQFSPFWLGVLFCICGLVY-ILSERNPS----KK--MITASLALS 113 zebrafish
CAG03430      31 fplvvallqlllgvavTVVAFLMLAISPS----LLARETPHWAGIILCLVSVLG-FILYCITY----LPdeRTSAQFICE 101 spotted green p...
P19437       115 SLSLFAAISGIILSIMDILNMTLSHFLkmrrleliqtskpyvdiydcepsNSSEKNSPSTQYCNSIqsvFLGILSAMLIS 194 house mouse
Q95PZ5       160 LVSVMMCLISGGLSARNWALVGTYHHPridrdeafcll--gthdtsrisyIFSHMDKYDFAKCLWQlkvGVAVNSVQFVI 237 Caenorhabditis ...
Q3TRE0        96 VFYFLLSALGLMVCMLAVAFAAHHYSLlaqftcet--------sldscqcKLPSSEPLSRAFVYRDvtdCTSVTGTFKLF 167 house mouse
Q1LVQ8       110 LLYFFLCTMGLVMSVVVIAFQCYHYTLtnsfscre--------mredcicTLDPEDPIARMFVFSAvsdCSDITSTLPMY 181 zebrafish
Q08BU9       111 IISTIGVVSACMDFIKSMVIIERQDEY-----------------------THNNITEDDYVYLRQH---YSAVVAMECVF 164 zebrafish
Q5BLA7        84 VVSLFAVVIVFVYACVTLSYGEEDDEI-----------------------FHAHPVPEVRFVLSRM---VKGANCTLLVA 137 zebrafish
XP_001633519  87 AVCVVLHMIGTILTGEVGGLLKSVLECqfsevdqsci---ccdsimtckqSVPSYKFEGVDDCDILtglLKELMYGLCVL 163 starlet sea ane...
XP_001626281  78 LVGLVTLFVCAIIIGLGVLQHFKFESSinreyyi---------akgpnyhKEYSRPQEHFDERNQNgenGVGIYGTLLAL 148 starlet sea ane...
AAI55057     114 IVSTFGVIFAVLDISQHISHNRWMVWFh----------------------RAHNMTETELLYMTQH---YSAVETMGCVF 168 zebrafish
CAG03430     102 VLYFILCSIGLVLSVLVVAFAGHHYSQasgfscgp--------argdcvcTLSQEDPIARTFTYEGvgdCQAITGTLTLY 173 spotted green p...
P19437       195 AFFQKLVTAGIVENEW 210 house mouse
Q95PZ5       238 AAIEVFLNILSAILCM 253 Caenorhabditis elegans
Q3TRE0       168 LIIQMVLNLVCGLVCl 183 house mouse
Q1LVQ8       182 YLLQVLLNLAQAIVCL 197 zebrafish
Q08BU9       165 LCHGLIGGVLLIIMTC 180 zebrafish
Q5BLA7       138 CTGSLLFSSLIAYIGC 153 zebrafish
XP_001633519 164 NIFGSLVCFIATILGC 179 starlet sea anemone
XP_001626281 149 IVMDVIVNLVTMAVCk 164 starlet sea anemone
AAI55057     169 LCHSLIGGVLLIIMTC 184 zebrafish
CAG03430     174 FLVQIVLNLAQALVCa 189 spotted green pufferfish
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