Conserved Protein Domain Family
Mannosyl_trans2

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pfam04188: Mannosyl_trans2 
Mannosyltransferase (PIG-V)
This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.
Statistics
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PSSM-Id: 282094
Aligned: 3 rows
Threshold Bit Score: 454.369
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NUD9   8 RKE--VLRFAVSCRILTLMLQALFN-AIIPDHHAEAFSPPRl-----aPSGFVDQLVEGLLGG-LSHWDAEHFLF--IAE 76  human
P38211   2 IVG--LTLYFVLFRSIQYLLVFLTPiRQFDTSTSLLLNELCs------SPSEINSYWNKYFWNkLLSWDSVFFIKniTSK 73  Saccharomyces cerevis...
Q6NKT6  12 rKEtiLIKYAIFSRLLVLFLTILWRsLLQPYDTSAALNPPClyhkedsFPFLVANAASRSLEN-SVVWDSVYFLR--ITE 88  thale cress
Q9NUD9  77 HG-YLYEHNFAFFPGFPLALLVGT-ELLRPLRGLLSLRSCLLISVASLN-FLFFMLAAVALHDLGCLVLHCPHQSFYAAL 153 human
P38211  74 NGkPQFEHEYAFSQLWTFFVRLFIkSNNDSIYHALRVGVAIENVLFYLSgIVLYFLTKKIFSQNIRQSQFARTIAKKTSL 153 Saccharomyces cerevis...
Q6NKT6  89 CG-YEYEQTYAFLPLLPFFISLLSrTVFAPLVPLIGLRAVMVLSGFTVS-NLAFIFAAIYLFRVSVIILKDTEASFRASI 166 thale cress
Q9NUD9 154 LFCLSPANVFLAAGYSEALFALLTFSAMGQLERGR--------VWTSVLLFAFATG-VRSNGLVSVGFLMHSQCQGFFS- 223 human
P38211 154 LFFLTSAAGFLTSIYSEPLSFFFAFVGIWSRECSIsvpvlgqfDISWRYWFPYSFIsMACFTLASLNRSNCVLLGIYFIf 233 Saccharomyces cerevis...
Q6NKT6 167 IFCFNPASIFYSSIYSESLYALFSIGGVYHLLSGT--------SNVGVLWFALSGC-ARSNGILNAGYICFQTMHRAYE- 236 thale cress
Q9NUD9 224 SLTMLNPLRQLFKLMASLFLSVFTLGLPFALFQYYA-YTQFCLPGsarpipeplvqlavdkgyriaeGnepPWCFWDVPL 302 human
P38211 234 DLIELTKNRKFVKAICFPLLSGSLMFSALLYQQYYLpYKTFCPQR----------------------G---EWCKSQLFS 288 Saccharomyces cerevis...
Q6NKT6 237 ALYQKRRAYLAMQVFIAGFLRCICICLPFVAFQAYG-YYNICHGHtrd--------------------evrPWCKGRIPL 295 thale cress
Q9NUD9 303 --------IYSYIQDVYWNVGFLKYYELKQVPNFLLAAPVAILVAWATWTYVTthpwlcltlglQRSKNNKTlekpdlgf 374 human
P38211 289 sifitktsLYSYIQSHYWGVGLLKYWTPNNIPNFLFAVPNIIILIYSSIYFSK-----------IYPSYNLKa------- 350 Saccharomyces cerevis...
Q6NKT6 296 --------LYNFIQSHYWGVGFLKYFQFKQLPNFLLASPILSLAVCSIMSYMKsrpelfislgfQATEKEKRsaarlysl 367 thale cress
Q9NUD9 375 ------------------------------------------lspqvfvYVVHAAVLLLFGGLCMHVQVLTRFLGsSTPI 412 human
P38211 351 -------------------------------------------------LVWITRALVVIVCFFAHVQILNRIAS-FLPL 380 Saccharomyces cerevis...
Q6NKT6 368 kdavepsvktstnegnhdirqrkpsskkdvtgtkvapeksgylsadvfpFIVHLSFMVTTAFFIMHVQVATRFLS-ASPP 446 thale cress
Q9NUD9 413 MYWFPAHLLQ--DqepllrsLKTVPWKPLAEDsppgqkvprnPIMGLLYHWKTcspvtryilgyflTYWLLGLLLHCNFL 490 human
P38211 381 HLWYLADRLVktS-------DPKKMENPKGDD----------KIVKFYIYWLA-------------FWIPLQTILFAAFL 430 Saccharomyces cerevis...
Q6NKT6 447 LYWFASSLIGs---------pKHSKWGYL--------------------IWSYc-----------aAYILLGTLLFSNFY 486 thale cress
Q9NUD9 491 PWT 493 human
P38211 431 PPA 433 Saccharomyces cerevisiae S288C
Q6NKT6 487 PFT 489 thale cress
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