Conserved Protein Domain Family
BEX

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pfam04538: BEX (this model, PSSM-Id:282406 is obsolete and has been replaced by 398300)
Brain expressed X-linked like family
This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.
Statistics
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PSSM-Id: 282406
View PSSM: pfam04538
Aligned: 69 rows
Threshold Bit Score: 56.51
Threshold Setting Gi: 91208341
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9BXY8        14 VENVNQEND--EK-DEKEQVAnKGeplalPLNVSEYCVPRGNRRRFrVRQPI-LQYRWDIMHRLGEP-QARMR--EENME 86  human
XP_006084729   1 MENVPKECEggEQaPVQNEEEa------rPLGGGEVQEPGGNVREA-WAPPA-QDFREDVPNRLVNN-IDMIDgdADDME 71  little brown bat
EAW54721      70 gENAQQENEggEQaPTQNEEE-Sr-----HLGGGEGQKPGGNIRRGrVRRLV-PNFRWAIPNRHIEH-NEa----RDDVE 137 human
XP_003802565  13 MENSKQENEggDQ-ATVQNEE-EPr----YLGGGEGRKPVTTVRRGrVWRLV-PNFRWGMPNKHVDY-NEa----GDNAE 80  small-eared galago
XP_002720400   1 MENVPKQNKvgEQ-AAVKNEE-Ea----rPLEGGEGQQPGGNIRGG-WVPPV-QDFGEDMPDRLANN-MDLIDgeADDME 71  rabbit
XP_004022504  14 MEDAQQENEggDQ-APLKTGD-Es----rDLGGGKVQKSGGNIRLGwVRRLV-PNFRWAISNRRIDH-NEV----GNNVE 81  sheep
XP_006163607  14 VDNARQKNEgeEQaSMQNEEE-SGr-----LGGDKGQKSGGNVKRGrVRRLV-PNFRWAMPNRHTDH-NEV----GDDVE 81  Chinese tree shrew
XP_011963102  50 MEKDPKERReeEQ-ALVQNEEa------cPMGGGEGAKPRENVRGD-WDPPA-QDFREDMPNGLVNNiDIIDGd-ADDME 119 sheep
XP_521186      1 MENVPKENKvvEK-------A-PVqneapALGGGEYQEPGGNVKGV-WAPPA-PGFGEDVPNRLVDNiDMIDGd-GDDME 69  chimpanzee
XP_008271343  14 aETVDQENEgeEQtPVQNEDEa------lHLGGSEGQKPEGSVRRG-RVRRLvPNFRWAIPNRNIDH-SDV----GDDVE 81  rabbit
Q9BXY8        87 RIGEEVRQLMEKLRE--------K--------QlshslravstdPPHHDHHDEF 124 human
XP_006084729  72 RFMEEMRELRRKIRE--------L--------QlryslriligdPPHHDHHDEF 109 little brown bat
EAW54721     138 RFVGQMMEIKRKTREqqmrhymrF--------Q-----------TPEPDNHYDF 172 human
XP_003802565  81 KFVGQMMEIKRKTKEqqvrnymrF--------Q-----------TPEPDNHYDF 115 small-eared galago
XP_002720400  72 RFMEEMRELRRKIRE--------L--------QlryslriligdPPHHDHHDEF 109 rabbit
XP_004022504  82 KHIGQMVEIKRKTKK--------QqmrhhvpyQ-----------TPEPDNHYEF 116 sheep
XP_006163607  82 RFVGQEMEIKRKTRDqqlrqymrF--------Q-----------TPEPDNHYDF 116 Chinese tree shrew
XP_011963102 120 RFMEEMRELRRKIRE--------L--------QlryslriligdPPHHDHHDEF 157 sheep
XP_521186     70 RFMEEMRELRRKIRE--------L--------QlryslriligdPPHHDRHDEF 107 chimpanzee
XP_008271343  82 RFVGQMMEIKRKTREqqikhyirF--------Q-----------TPEPDNHYDF 116 rabbit
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