Conserved Protein Domain Family
Gasdermin

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pfam04598: Gasdermin (this model, PSSM-Id:282457 is obsolete and has been replaced by 398339)
Gasdermin family
The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein
Statistics
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PSSM-Id: 282457
Aligned: 14 rows
Threshold Bit Score: 458.397
Created: 12-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9D8T2         4 AFEKVVKNVIKEVSgSRGDLIPVDSLRNSTSFRPYCLLNRKF-SSsRFWK-PRYSCVNLSIKDILEPSA-PEPEPECFGS 80  house mouse
P57764         4 AFERVVRRVVQELD-HGGEFIPVTSLQSSTGFQPYCLVVRKP-SSsWFWK-PRYKCVNLSIKDILEPDA-AEPDVQRGRS 79  human
Q3TR54         4 SFDRASKDVVKKLQ--GRDLRPVECLSDATKFRLFHILQETP-RS--GWE-TEDIPVGFTLLDLLEPNF-PVPEPEVSAP 76  house mouse
Q99NB5         4 TFDWLSKDVVKKLQ--GRDLRPVKCLSDATKFCLFNILQETS-SR-LALK-TEYIPVGFTLLHLLEPNI-PVPEPEVSAP 77  house mouse
Q6J2R6         1 MFAKATKNLLSEID-SEGFLIPVLCLNDSDGLSPQALVIKRN-RY-WFWQqPKYKPTDFKLSDVLVGDP-INPVVVETEF 76  zebrafish
Q9Z2D3         1 MFAKATRNFLKEVD-AGGDLISVSHLNDSDKLQLLSLVTKKK-RY-WCWQrPKYQILSATLEDVLTEGHcLSPVVVESDF 77  house mouse
O60443         1 MFAKATRNFLREVD-ADGDLIAVSNLNDSDKLQLLSLVTKKK-RF-WCWQrPKYQFLSLTLGDVLIEDQfPSPVVVESDF 77  human
Q96QA5         3 MFENVTRALARQLN-PRGDLTPLDSLIDFKRFHPFCLVLRKR-KStLFWG-ARYVRTDYTLLDVLEPGS-SPSDPTDTGN 78  human
Q32M21         3 MFEDVTRALARQLN-PRGDLTPLDSLIDFKRFHPFCLVLRKR-KStLFWG-ARYVRTDYTLLDVLEPGS-SPSDPTLLGN 78  house mouse
NP_001039625   4 AFEKVVRSVVRELD-H-KDLTPVDSLWSSTSFQPYTLLSRKPlSS-RFWR-PRYKCVNLSIRDILEPDA-PEPALECGRT 78  cattle
Q9D8T2        81 FKVSDVVDGNIQGRVMLSGM-GEGKISGGAAV-SDSSSASMNVCILRVTQKTWETmqhERHLQQPENKILQQLRSRG-DD 157 house mouse
P57764        80 FHFYDAMDGQIQGSVELAAP-GQAKIAGGAAV-SDSSSTSMNVYSLSVDPNTWQTllhERHLRQPEHKVLQQLRSRG-DN 156 human
Q3TR54        77 KPFIHVQSTDLEANLNVA------DIARGGVGyVGYGGYNIEVQSTSIPNPKLEIl-qNRKLLDKLPTFMKFCRMER-KN 148 house mouse
Q99NB5        78 IPLKHTISQKLKADLDVE------TIAGGEAGfVKSCGYDIEVQSKSIPNPKLESl-qNRKLLDQLPTFMKTCWKDG-KN 149 house mouse
Q6J2R6        77 LTYKGKVMDTKSGSAVAELGpGTINIGGSGSSkLQSSFGNLKKQELDLQKLLHDS---KSRVLDMQHSLIQQTRNAKtEV 153 zebrafish
Q9Z2D3        78 VKYESKCENHKSGAIGTVVGkVKLNVGGKGVVeSHSSFGTLRKQEVDVQQLIQDA---VKRTVNMDNLVLQQVLESRnEV 154 house mouse
O60443        78 VKYEGKFANHVSGTLETALGkVKLNLGGSSRVeSQSSFGTLRKQEVDLQQLIRDS---AERTINLRNPVLQQVLEGRnEV 154 human
Q96QA5        79 FGFKNMLDTRVEGDVDVP---KTVKVKGTA---GLSQNSTLEVQTLSVAPKALETv-qERKL-AADHPFLKEMQDQG-EN 149 human
Q32M21        79 FSFKNMLDVRVEGDVEVP---TMMKVKGTV---GLSQSSTLEVQMLSVAPTALENlhmERKL-SADHPFLKEMREYK-QN 150 house mouse
NP_001039625  79 FQFHDAMDGQLQGSVKLAAP-GQGRLS-GGAAvSGSSSASMDLCTLRVTPNTWEAmhhERRLRQPEPKTLQQLRSRG-DD 155 cattle
Q9D8T2       158 LFVVTEVLQTKEEVQITEVHSQEGSGQFTLPG-ALCLKGEGKGH------QSRKKMVTIPAGSILAFRVAQLLIGSK--W 228 house mouse
P57764       157 VYVVTEVLQTQKEVEVTRTHKREGSGRFSLPG-ATCLQGEGQGH------LSQKKTVTIPSGSTLAFRVAQLVIDSD--L 227 human
Q3TR54       149 LYVVTEAYEVSKDTMLTGLSSVNLLVKGFFKQ-LFKVRGKAG--------RSEKYSIPIPKGSVLAYKKQQLVIENNtcV 219 house mouse
Q99NB5       150 LYVVTEAYEVTKDTVLEGTSNSKFAIKGIINQ-LVKVGGSGQWQ------TEKTDSIPIQKGSVLAYKKQQLVIEDNtcV 222 house mouse
Q6J2R6       154 LAVVKERIITTQPCTITEEVQEGGSCTGMFGF-NKTIKVSSNDKgkpsiaYDTDVSIDIPPKTTLAYSVIELDIAHTghY 232 zebrafish
Q9Z2D3       155 LCVLTQKIMTTQKCVISEHVQSEETCGGMVGIqTKTIQVSATEDgt--vtTDTNVVLEIPAATTIAYGIMELFVKQDgqF 232 house mouse
O60443       155 LCVLTQKITTMQKCVISEHMQVEEKCGGIVGIqTKTVQVSATEDgn--vtKDSNVVLEIPAATTIAYGVIELYVKLDgqF 232 human
Q96QA5       150 LYVVMEVVETVQEVTLERAGKAEACFSLPFFA-PLGLQGS----------INHKEAVTIPKGCVLAFRVRQLMVKGKdeW 218 human
Q32M21       151 LYVVMEVVKAKQEVTLKRASNAISKFSLNLP--SLGLQGS----------VNHKEAVTIPKGCVLAYRVRQLIIYGKdeW 218 house mouse
NP_001039625 156 VFVVTEVLQTQKEVEVTRTHKQEGSGQFALPG-AFCLQGKGEGH------LSQKKTVTIPSGSTLAFRAAQLVIGSD--W 226 cattle
Q9D8T2       229 DILLVsDEKQRTFEP---------SSGDRKAVGQRHHGLNVLAALCSIGKQlsllsdGIDEEELIEAADFQGLYAE---V 296 house mouse
P57764       228 DVLLFpDKKQRTFQPpa------tGHKRSTSEGAWPQLPSGLSMMRCLHNFl----tDGVPAEGAFTEDFQGLRAE---V 294 human
Q3TR54       220 ILPSA-TKKKMTFPDrplklydlpVTLRYQEEVIETGSWIDDi-------------dPIGTIEEPANLNFMCLQHE---V 282 house mouse
Q99NB5       223 ILTSAnTKKKMTFPMrfv---gmsGHLRYQDLVIETGSWINDi-------------dPIGTIKEPTHLDFMCLQNE---V 283 house mouse
Q6J2R6       233 ELCLL-PAVKGGFEI-------------------------------DGPVKv----kQAVTVSAAPGNPTHNMQKElvgL 276 zebrafish
Q9Z2D3       233 EFCLL-QGKHGGFEHer-----klDSVYLDPLAYREFAFLDMl--------------DGGQGISSQDGPLRVVKQAtlhL 292 house mouse
O60443       233 EFCLL-RGKQGGFENkk-----riDSVYLDPLVFREFAFIDMP--------------DAAHGISSQDGPLSVLKQAtllL 292 human
Q96QA5       219 DIPHIcNDNMQTFPP---------------------------GEKSGEEKVi----lIQASDVGDVHEGFRTLKEE---V 264 human
Q32M21       219 GIPYIcTDNMPTFNP----------------------------L-CVLQRQg----sTVQMISGEMHEDFKTLKKE---V 262 house mouse
NP_001039625 227 DILLFpDKKQRTFLSlq------aGRRPSSSADSHPHPCFSLASIRALSDYfhfqpdGSTEHWLATTDDYQGLRAE---V 297 cattle
Q9D8T2       297 KACSSELESLEMELRQQILVNIGKILQDQPSMEALEASLGQGLCSGg---------QVEPLDGPAGCILECLVL------ 361 house mouse
P57764       295 ETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLG----------PVEPLDGPAGAVLECLVL------ 358 human
Q3TR54       283 SEQTQLLAELSKDVQEVVFSSFLHMLSDRDVLYDLMKMLELN--------------QLGHMDGPGGKILDELRK------ 342 house mouse
Q99NB5       284 SEQTRLLAELSKDVQEVVFSSFLHMLCDRDVLYDLMKMLELN--------------QLGHMDGPGGKILDELRK------ 343 house mouse
Q6J2R6       277 EGQFKVLSKLPSSTRFSLFQQISLLLQNSAVISILGSTLEDLCGGTqp-------dPSTLAEVPELKVTLELIQksag-- 347 zebrafish
Q9Z2D3       293 ERSFHPFAVLPAQQQRALFCVLQKILFDEELLRALEQVCDDVAGGLwssqavlameELTDSQQQDLTAFLQLVGyriqge 372 house mouse
O60443       293 ERNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGLsptv--avlgELKPRQQQDLVAFLQLVGcslqg- 369 human
Q96QA5       265 QRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALE------------------GALDKGHEVTLEALPK------ 320 human
Q32M21       263 QQETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQMLE------------------GALDKGHEVTLEALPK------ 318 house mouse
NP_001039625 298 KAWAMGLEGLSKGLCGQLLGGLGQVLRDEPALQALEDSLEQGLCSG----------PVEPRDGPVGAILESLVL------ 361 cattle
Q9D8T2       362 ----DSGELVPELAAPIFYLLGALAVLSETQQQLLAKALETTVLSKQLELVKHVLEQSTPwqeqssvSLPTVLLGDCWDE 437 house mouse
P57764       359 ----SSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPwqerstmSLPPGLLGNSWGE 434 human
Q3TR54       343 ----DSSTPHDVLKDLNLYLLQALLVLSDTQLCLLAQSVKMGLLPHQVELVKSILQTNFKyssntpfTLQPQLLAPLQGE 418 house mouse
Q99NB5       344 ----DSSLSWINLKDLILYLLQALMVLSDTQLCLLALSVEMRLLPHQVELVKSILQPNFKypwnipfTLQPQLLAPLQGE 419 house mouse
Q6J2R6       348 -kkpSGQHQKQSTLTATHLLISALDEMSKPALFLLKSCCSYTTLQALLHLVQNMALNEKS-------SLKDAALDVLADE 419 zebrafish
Q9Z2D3       373 hpgpQDEVSNQKLFATAYFLVSALAEMPDNATVFLGTCCKLHVISSLCCLLHALSDDSVC-------DFHNPTLAPLRDT 445 house mouse
O60443       370 gcpgPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVS-------DLEDPTLTPLKDT 442 human
Q96QA5       321 -----DVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLldkegvfPLQPELLSSLGDE 395 human
Q32M21       319 -----DVLLLKDAMDAILYFLGALTELSEEQLKILVKSLENKVLPVQLKLVESILEQNFLqdkedvfPLRPDLLSSLGEE 393 house mouse
NP_001039625 362 ----PSGQLETELAGPVFYLLQALAVLSEAQHVLLAEVLEMGALSGTFWLVESLVEQSSPwqehravSLPPERLGDSWGS 437 cattle
Q9D8T2       438 K--NPTWVLLEECGLRLQ--VESPQV 459 house mouse
P57764       435 G--APAWVLLDECGLELG--EDTPHV 456 human
Q3TR54       419 Gl-AITYELLEECGLKME--LNNPRS 441 house mouse
Q99NB5       420 Gl-AITYELLEECGLKME--LNNPRS 442 house mouse
Q6J2R6       420 VvfKNITSLFNSCNVMLLk-DDNSLI 444 zebrafish
Q9Z2D3       446 ErfGIVQRLFASADIALErmQFSAKA 471 house mouse
O60443       443 ErfGIVQRLFASADISLErlKSSVKA 468 human
Q96QA5       396 El-TLTEALVGLSGLEVQ--RSGPQY 418 human
Q32M21       394 Dq-ILTEALVGLSGLEVQ--RSGPQY 416 house mouse
NP_001039625 438 E--APGWALLEACGLEPQ--VGTPQV 459 cattle
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