Conserved Protein Domain Family
Radial_spoke
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pfam04712: Radial_spoke (this model, PSSM-Id:282555 is obsolete and has been replaced by 461405)
Radial spokehead-like protein
This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologues, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene.
Links
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Statistics
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PSSM-Id: 282555
Aligned: 44 rows
Threshold Bit Score: 399.316
Created: 24-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9W1D3         86 VAKSILQKySTLSG--DNLFDHLSDIIKRVIDERPPNVI---DFFEEFSRNVREQKF---------HLPERFPPSGVFDE 151  fruit fly
Q4DHQ3         45 IAMTGLTE-NEIRE--SPLWQHMKKVLLQVVQQQPSSAL---DAIIPSSFVVQTGSAvpph--attIYADHRPRVTNAVP 116  Trypanosoma c...
Q4DE57         16 RTKAYLMN-ANKDG--VSVYDQLTRLMEQLLDENPHDIAadpSRFNEIFTLLQQSSFvng---qstPACNEPCSVPPFEL 89   Trypanosoma c...
XP_001360876   88 VAKAIMQQySTLSG--DNLFDHLSDIIKRVIDERPPNVI---DFFEEFSRNVREQKF---------HLPERFPPNGIFDE 153  Drosophila ps...
XP_002063482   93 VAKSIMQQySTLSG--DNLFDHISDIIKRVIDERPPNVI---DFFEEFSRNVREQKF---------HLPERFPPQGVFDE 158  Drosophila wi...
XP_002049995   90 VAKSVLQQySTLSG--DNLFDHLSDIVKRVVDERPPNVI---DFFEEFSRNVREQKF---------HVPERFPPNGVFAD 155  Drosophila vi...
CDS26358       17 ETKALLMScHPGDNqsASVYDLMTGITKYIAENQPSQAF---DQFEEISRFIKLEMGmgd---tlgAVPTKNPKPLEAEF 90   Hymenolepis m...
XP_001700728    9 QALAYLQVhSPQDG--TSMYDHLVKLVSKVLEDQPKNAV---DLLET-SLLVKKSTFdpk----esSPLVPIPVAPDATQ 78   Chlamydomonas...
XP_002675993   12 DAKAYLQTt-NENG--KSIYDMLIDIVSYLQDHKDAKEI----NLKKLVEQLSEDGFkygersgfdELWKLSKPNPESCN 84   Naegleria gru...
XP_001987084   93 IAKSILKQySTLSG--DNLFDHISDIVKRVVDERPPNVI---DFFEEFSRNVREQKF---------HVPERFPPNGVFAD 158  Drosophila gr...

Q9W1D3        152 VRSFR--VakKILQSMKLPYVVEgedlm-gedlsV-----E----D---------L---------------R----TN-- 189  fruit fly
Q4DHQ3        117 SDALE--NlrWASSFGNVLAPPKprrkpteedeeM-----P----Q---------E---------------E----AE-- 155  Trypanosoma c...
Q4DE57         90 ARLAD--NerLFDRPPP-----------------------E----T---------L---------------T----TI-- 110  Trypanosoma c...
XP_001360876  154 VRTFR--VarQILQSMQLPYSIE-----------G-----E----DlagaedlygE---------------DgkaiDD-- 194  Drosophila ps...
XP_002063482  159 SRMFRiaK--TILQSMKLPYNIE-----------T-----EdfgiQ---------E---------------D----VS-- 190  Drosophila wi...
XP_002049995  156 SRMFR--PakKILHSIKLPHNIE-----------G-----I----D---------F---------------G----GE-- 183  Drosophila vi...
CDS26358       91 AEKER--T--LYSHPDHVWNKPPlvetnlpesysG-----N----F---------E---------------E----DT-- 127  Hymenolepis m...
XP_001700728   79 TQAAV--S--IFGDPELPINPAT-----------G-----E----Pv-------pA---------------D----PP-- 106  Chlamydomonas...
XP_002675993   85 KAREI--VevLSKQQNVMKEEFS-----------KrkkaiE----E---------LnvkkdgdddnqddpvE----ENpd 134  Naegleria gru...
XP_001987084  159 CRMFR--PakQILHSIKLPHSGEnldfegdedlgG-----E----E---------------------------------- 193  Drosophila gr...

Q9W1D3        190 ------EDmrividd-------------smryfvT-FNERVQQLQFYWTQCGFSISNDDIFQLASAMNRL--QTHPSI-- 245  fruit fly
Q4DHQ3        156 ------ENeee--------------------vllG-EVSNVVGEQAIFNSVGEGLQPEEAFRLVVGMKQL--VKTEPL-- 204  Trypanosoma c...
Q4DE57        111 ------EQpdpyttvtt---------trikphtaP-PYDSVAQHNLYWAWAGCGVTEEEAFLLDRSITML--AMEKKL-- 170  Trypanosoma c...
XP_001360876  195 ------EElrividd-------------smrlfvT-FNERVQQLQFYWNQCGFSISNDDIFQLACAMNRL--QTHPSI-- 250  Drosophila ps...
XP_002063482  191 ------AEdktnvdddfri-----viddsirhfvT-FNERVQQLQFFWNQCGFSISNDDTFQLACAMNRL--QTHPSI-- 254  Drosophila wi...
XP_002049995  184 ------EDlpseeaftygdgdlridlddsmrlfvT-FNERVEQLQFFWNQCGFSISKDDIFQLASSINRL--QTHPSI-- 252  Drosophila vi...
CDS26358      128 ------EE--------------------------TqVLGNVGQEFSLIEQSGIGLGREELTRIWLALRHLrkVLGDDV-- 173  Hymenolepis m...
XP_001700728  107 ------NE--------------------------F-EAENMLGAAAVLDCLGVGLGRELGVNIALAAKRI--GEDPKLav 151  Chlamydomonas...
XP_002675993  135 imylysNE--------------------------D-GVSNLIEDFYALELVGVGLPHEEIAKLSVAIQNL--KSSKSL-- 183  Naegleria gru...
XP_001987084  194 ------FEaelrinid-----------dsmrmfvT-FNERVEQLQFYWNQCGFSISKDDIFQLASSINRL--QTHPSI-- 251  Drosophila gr...

Q9W1D3        246 MQCRFWGCINGLKASYYIVEASLT--REEIAS-------------------RLVMMeeemrqkqipfpmrkdredkpppa 304  fruit fly
Q4DHQ3        205 ATARFWGKILGSGADYYIVETKID--PERLPE-------------------DEEDV------------------------ 239  Trypanosoma c...
Q4DE57        171 RDVRFFGKIFGTKADYYVVSSQRYvqDGEKVY-------------------KEVNT------------------------ 207  Trypanosoma c...
XP_001360876  251 MQCRFWGCINGLKASYYIVEATLT--REEIQS-------------------RMAMMadelrekqlplkmrhdreekplpp 309  Drosophila ps...
XP_002063482  255 MQCRFWGCINGLKASYYIVEASLT--REEIAS-------------------RLVMMeeemrekqlplkmqknreekpapp 313  Drosophila wi...
XP_002049995  253 MQCRFWGCINGLKGSYYIVEASLT--REELNSrmammeeemrekqlpfkmrKNQEQkplpthig---------------- 314  Drosophila vi...
CDS26358      174 SKLRFWGKIFGMNANYYIIEAEFQ--AGSEPS-------------------PSIPGpwddwrypkpgpk---------wp 223  Hymenolepis m...
XP_001700728  152 RSVRFFGKFLGLYSDYFVFEVAFK--K--EAA-------------------KEAAPaapap------------------- 189  Chlamydomonas...
XP_002675993  184 RYLRFVGKILGIESHYYVVESNYY--FKEK-------------------------------------------------- 211  Naegleria gru...
XP_001987084  252 MQCRFWGCISGLKASYYIVEASLS--REEIAS-------------------RLTMMkeemrekqlpfkvrknqeakpapa 310  Drosophila gr...

Q9W1D3        305 higpeltpgiyGWEEFPPEElekMKPKAAPVPlveem---elydIPPEFIGKGCNRYSYFVVNSLF--DDWIELPIVTPR 379  fruit fly
Q4DHQ3        240 -----------GMADDEEEE---GTPIDNVADvlysygakkqadTEVEPAGSGLNEWVYYAAQTADp-TSWTRLPDVTPN 304  Trypanosoma c...
Q4DE57        208 ------------------------MPRPARRKle--------vpVQPEPGFVGVNRLSFWVTSHPA--AEWKLLPDVTPQ 253  Trypanosoma c...
XP_001360876  310 higpeltpgvyGWENYPIEEleiMKPKAPDVPlveei---efydIPPEYIGVGCNRYSYFVVNSLY--DDWIELPIVTPR 384  Drosophila ps...
XP_002063482  314 higpeltpgiyGWDNYSPEElvhMKPKAAAVPlvqem---efydIPPEYIGLGCNRFSYFVVNSLY--DDWIELPIVTPR 388  Drosophila wi...
XP_002049995  315 ---peltpgvyGWETYALEDlekMTPKAEPVPlaeei---efydIPPENVGLGCNRYSYFVVNCLY--NDWIELPIVTPR 386  Drosophila vi...
CDS26358      224 dpesfiamiknGRERDTPDSlmtDLPRVVYEPpi---------rYPPESRGSGLNKWDYYVSSSLGe-GDWVRLPSVRPE 293  Hymenolepis m...
XP_001700728  190 -------erveGEAASSSAp-----------------------eVPVEEPGKGANKFTYLVCSSLG--GPLTRLPDVTPA 237  Chlamydomonas...
XP_002675993  212 ------------------------------VPqd---------kIHESGGKAGLNRFTYWVLRSKDslTNFVNLPDVTPQ 252  Naegleria gru...
XP_001987084  311 higpeltpgtyGWELYAKDElekMTPKAKPVPlaeei---evydIPPEYIGNGCNRFSYFVVNCLH--NDWIELPIVTPR 385  Drosophila gr...

Q9W1D3        380 QIVVSRQIKKFLTGDLEADVISYPCFPGKEKHYLRTLIGRITAGTYIAPVGYY---------Rrmtkkeqrmfdgeeeee 450  fruit fly
Q4DHQ3        305 QVIVARHIRRGFTGDLESSVDTHPHFPGKEMNYLRAQIARISCACRVAPRDMY---------Tseg-------------- 361  Trypanosoma c...
Q4DE57        254 QILAGRRIKRLFTGDLNAAVIASPPFEWNEAVYLRVQLSRIASGTYISPMGAL---------Ee---------------- 308  Trypanosoma c...
XP_001360876  385 QVVVSRQIKKFLTGDLESDVISYPCFPGKEKHYLRALIGRITAGTYIAPIGYYrrmtkkekrMf---------------- 448  Drosophila ps...
XP_002063482  389 QIVVSRQIKKFFTGDLEADVISYPCFPGKEKHYLRAMIARITAGTYIAPQGYY---------Rr---------------- 443  Drosophila wi...
XP_002049995  387 QIVVSRQIKKFFTGDLEADVVSYPCFPGKEKHYLRAMIARITAGTHIAPQGYY---------Rrmtkk---------ekn 448  Drosophila vi...
CDS26358      294 QIVAARNLVCLFAGDLNRNLSDF-AFPGLEVHYLRAQIARISSGTHISPSGVF---------Ei---------------- 347  Hymenolepis m...
XP_001700728  238 QVKASRRIKKLLTGRLTSHVSTYPAFPGNEANYLRALIARISAATVVAPSDLF---------Sl---------------- 292  Chlamydomonas...
XP_002675993  253 QINAARNISKLFTGNLEKEIISYPPFPGNEANYLRAQIARIVHSTTIAPFDLF--------------------------- 305  Naegleria gru...
XP_001987084  386 QIVVSRQIKKFFTGDLEADVVSYPCFPGKEKHYLRAVIGRITAGTYIAPQGYY---------Rrmtkkeknl-ydginln 455  Drosophila gr...

Q9W1D3        451 geEE---------------EE-----------------E----------------------EEEEEFn------------ 464  fruit fly
Q4DHQ3        362 avPE---------------EE-----------------D----------------------EEGNVL------------- 374  Trypanosoma c...
Q4DE57        309 --PE---------------EE-----------------V----------------------DEEEEAe------------ 320  Trypanosoma c...
XP_001360876  449 --EG---------------NDldegeeeeeeeedesvnE----------------------GEDDQIe------------ 477  Drosophila ps...
XP_002063482  444 --MT---------------KR-----------------EkrlfeggevdeeeeeeeeedfeGEEDTLd------------ 477  Drosophila wi...
XP_002049995  449 lfDGinldeeeeveeednyNE-----------------G----------------------EEEE-Iq------------ 476  Drosophila vi...
CDS26358      348 --DE---------------DL-----------------I----------------------EEGEQ-------------- 357  Hymenolepis m...
XP_001700728  293 --ND---------------ET-----------------G----------------------E------------------ 298  Chlamydomonas...
XP_002675993  306 --------------------E-----------------E----------------------REVTEAndeddddsnekkk 326  Naegleria gru...
XP_001987084  456 qeEE---------------EE-----------------E----------------------EEEDDFn------------ 469  Drosophila gr...

Q9W1D3        465 ------------eGeeeq-------iednDVMLLKNEKYEAE--PLG---------SLATp-----------VAWVHVRS 503  fruit fly
Q4DHQ3        375 -------------PppesvkayttlppltPQEVPDEEDTEAIe-PIKswfygyrddELLQg-----------KYWVHIAP 429  Trypanosoma c...
Q4DE57        321 ------------dDeg------------dAAKKPREAKYRPLtqPVK---------GFASeedsdvtqwaklDQWVHSEG 367  Trypanosoma c...
XP_001360876  478 ------------dN---------------DVMLLKNEKYEAE--PLG---------SLSTp-----------VAWVHVRS 508  Drosophila ps...
XP_002063482  478 ------------dN---------------DVMLLKNERYEME--PLG---------SLETp-----------iAWVHVRS 508  Drosophila wi...
XP_002049995  477 ------------dN---------------DVMLMKNERFEIE--PLS---------SLATp-----------VAWVHCRP 507  Drosophila vi...
CDS26358      358 -----------------------------PEGLILAEEYEPM--EFG---------DLLDp-----------MNWVHHKP 386  Hymenolepis m...
XP_001700728  299 --------------------------------LERAEDWEPP--AGR---------EMAAp-----------TAWVHVRP 324  Chlamydomonas...
XP_002675993  327 kneikykevlpppV---------------KTKAFELKDPEGMks---------------------------lEHWVHLYP 364  Naegleria gru...
XP_001987084  470 ------------eGkeee-------sqdnDIQLMRNERFEIE--PLS---------TLATp-----------AAWVHVRS 508  Drosophila gr...

Q9W1D3        504 NILNqQGRVVwydeekarkerekalalylkmqmlgemEE-EV------------------------------EEEEDEE- 551  fruit fly
Q4DHQ3        430 TLLQ-TGRTV---------------------------AR-EQ------------------------------EEEDTGF- 449  Trypanosoma c...
Q4DE57        368 YIYA-NGRQTkv------------------------pEK-QE------------------------------DEEEEEA- 390  Trypanosoma c...
XP_001360876  509 NILN-QGRVVwfde-------------------ekaqKE-REkalalylkmrlleemeeeveeeeevedeeeGEEEGMI- 566  Drosophila ps...
XP_002063482  509 NILN-QGRVVwfde-------------------ekaqKE-REkalahylkmrlm------eemeeeieeeeaEDEEEGD- 560  Drosophila wi...
XP_002049995  508 NILN-QGRVVw----------------------------------------------------------------yDEE- 521  Drosophila vi...
CDS26358      387 FIFS-NGRISwmsr-------------------kraaEAiKE------------------------------MIERGEE- 415  Hymenolepis m...
XP_001700728  325 HLKS-QGRCEvhk---------------------relPE-DA------------------------------DEDEFYN- 350  Chlamydomonas...
XP_002675993  365 GILK-SGFITkeplp------------------gdqePA-DP------------------------------EDDKDPEv 394  Naegleria gru...
XP_001987084  509 NILN-QGRVVwydeeladkerkkalamylkmraleemGE-EL------------------------------EEEEDAE- 555  Drosophila gr...

Q9W1D3        552 ---Egeeegeee-------------------------------gmiegfnQ--PEL------------------------ 571  fruit fly
Q4DHQ3        450 ---D----------------------------------------------H--SEK------------------------ 454  Trypanosoma c...
Q4DE57        391 ---Eelqqqqqqe----------------------------eeeeeeeeeE--EEE------------------------ 413  Trypanosoma c...
XP_001360876  567 ---Dgfn---------------------------------------------qpeT------------------------ 574  Drosophila ps...
XP_002063482  561 ---Eegil--------------------------------------dhfiQ--PET------------------------ 573  Drosophila wi...
XP_002049995  522 ---KarkerekmlalyiksrlleemeeeieeeeaegeeegeeeemlegftH--PET------------------------ 572  Drosophila vi...
CDS26358      416 ---Epdev--------------------------------------pegtE--KKTdevmeekdedeeeeeeeeeeepee 452  Hymenolepis m...
XP_001700728  351 ---Ed---------------------------------------------E--LEE------------------------ 356  Chlamydomonas...
XP_002675993  395 psfKllqe--------------------------------------ddglKkcKEA------------------------ 412  Naegleria gru...
XP_001987084  556 ---Eeedgeee--------------------------------dmlegfiH--PET------------------------ 574  Drosophila gr...

Q9W1D3        572 -GPSILSSCAND----M--------------------------------NPE-V--------PV-S-------------- 590  fruit fly
Q4DHQ3        455 -IHPFLCEVSRDdpltYas-----------------------------hSRS-Q--------LP-A-------------- 480  Trypanosoma c...
Q4DE57        414 -ERELFTPINLDflyaVinipeppkvdeedeeeeeedddpaedaadaekDFD-D--------MP-Pkpvtdadvpdddpt 482  Trypanosoma c...
XP_001360876  575 -GPSILSSCAND----M--------------------------------SPE-V--------AV-P-------------- 593  Drosophila ps...
XP_002063482  574 -GPSILSSCGSD----T--------------------------------KDE-V--------RQ-P-------------- 592  Drosophila wi...
XP_002049995  573 -GPDILSSCASD----M--------------------------------SRE-C--------AF-P-------------- 591  Drosophila vi...
CDS26358      453 eGVDLLATVNEEdpvaM--------------------------------DMSaA--------IP-A-------------- 477  Hymenolepis m...
XP_001700728  357 -GPDLLAALEED----A--------------------------------QLP-G--------EQaA-------------- 376  Chlamydomonas...
XP_002675993  413 -GASPKKK-SED----D--------------------------------DND-DdgenkeakLS-C-------------- 438  Naegleria gru...
XP_001987084  575 -GPNILSSCAGD----M--------------------------------SNV-C--------SI-P-------------- 593  Drosophila gr...

Q9W1D3        591 ------WLARMT-----SKYTnQ-KERMLVMQSNVWPGAYTFI---FE---K---TCESIYLGWGHK-YYARNIPFKHLP 648  fruit fly
Q4DHQ3        481 ------WSFRKA-----FHNEsS-KTRTYVARSATWPGAFTYAvveLGqpgS---QYQSVYIGTGLKsLQGMNYAPKLPP 545  Trypanosoma c...
Q4DE57        483 kvkiaaWTVRVV-----NNNS-K-KHRVVVVRSLRWPGAVAFA---AEg-gK---KWGCVYFGNGLN-KTDFSFTPTLAP 547  Trypanosoma c...
XP_001360876  594 ------WLIRQT-----SKYTnQ-KERVLIMQSNVWPGAHTFI---FE---H---ICESIYLGWGHK-YYARNMPFNHLP 651  Drosophila ps...
XP_002063482  593 ------WLVRLT-----SKYTnQ-KERMLVMQSNVWPGAFTFI---FEq------TCESIYLGWGHK-YVARNMPFKHLP 650  Drosophila wi...
XP_002049995  592 ------WLVRFT-----SRYTnQ-KERLLVLQSNVWPGAFTFV---FEn------TCESVYLGWGHK-FCQRNIPFKHLA 649  Drosophila vi...
CDS26358      478 ------WSFRSS-----TILL-PvNCAIAVASNTRWPGAYALA---RD---R---AFTNIYLGWGKK-HIINGSKVPGPP 535  Hymenolepis m...
XP_001700728  377 ------WTPIYS-----SASEaV-KTQAGGLRSLVWPGAVCGG---RG---S---EWTCVYVGWGVK-Napfvplppppv 434  Chlamydomonas...
XP_002675993  439 ------WKVSFSnvrkqTCHH-K-SFKVVMLSSLRWQGAHTFY---RNi--GpicHFGNVYIGYGIK-NTGIPYTPILPS 504  Naegleria gru...
XP_001987084  594 ------WGVRFT-----SKHTnQ-KERILIMQSNIWPGAFTFI---FE---N---TCESIYMGWGHK-FSKRNIPFNHLP 651  Drosophila gr...

Q9W1D3        649 MVQEEF-PhNPe-dFVEANDPTVEEEEAYKAW 678  fruit fly
Q4DHQ3        546 RCLVEY-PeTE---LVLQRDATADDELEYAPP 573  Trypanosoma cruzi
Q4DE57        548 PVLPEC-Gd-----ITEVDDPTPATEKLVRRG 573  Trypanosoma cruzi
XP_001360876  652 MVQEEY-T-HGaedFIEASDPTVEEEAAYREW 681  Drosophila pseudoobscura pseudoobscura
XP_002063482  651 PVQEEF-I-HGpedFIEASDPSVEEEAAYREW 680  Drosophila willistoni
XP_002049995  650 IVQEEF-PhQAd-dFIEATDPTLEDELAYKNW 679  Drosophila virilis
CDS26358      536 EFLKEFdE-KLa-nLIEISDPTEQELEDARlr 565  Hymenolepis microstoma
XP_001700728  435 aqefawgevetqelelkpappppeeeaeade- 465  Chlamydomonas reinhardtii
XP_002675993  505 KVVEDV-K-EPv----dQVDPKPNDAKRMLQG 530  Naegleria gruberi strain NEG-M
XP_001987084  652 PVQSEY-PhTIe-dFIESTDPSVEDELAYKEW 681  Drosophila grimshawi
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