Conserved Protein Domain Family
MGAT2
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pfam05060: MGAT2 (this model, PSSM-Id:282863 is obsolete and has been replaced by 461539)
N-acetylglucosaminyltransferase II (MGAT2)
UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors.
Links
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Statistics
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PSSM-Id: 282863
Aligned: 39 rows
Threshold Bit Score: 400.861
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9FT88        80 RNHFSPRNT----------D--LF--PDLAKDR-VVIVLYVHNRAQYFRVTVESLSKVKGISETLLIVSHDGYFEEMNRI 144 thale cress
Q69QZ8        89 RNALPPRNA----------D--RF--PRLPDGH-LNIVLYVHNRPRYLRLVVDSLSRAHGIGEALLIVSHDGYFPEMDKI 153 Japanese rice
XP_002116702   7 KNYVLLKNNlqtv---lnsH--LLqsTSNHKFD-LVVVVQSHKRYKYLQALMQSLHKARGINKILLIVSHDYLLTEMRTV 80  Trichoplax adha...
XP_004990454 172 RQRAAAMNRaqtiqnpaicK--QH--LLNNNDDlVVFVVMAHNRLNYFEALLQSMRAVRYIEDAVLVVSQDMFSSEQDAL 247 Salpingoeca ros...
XP_004343299 159 RAKVAQMNSnivv---qnnNdaRL--PALKPNF-PVIVIQIHNRLLYFMHTIQSLAQVENIGSALIVLSHDFWDEPIMDY 232 Capsaspora owcz...
CDJ03124     121 RNHILSINEaqyi---hniD--RF--GK-ASPL-FIIIIQVHQRYTHLLYLIESLRRVRGIEEALVVFSHDFFSPEINRM 191 Echinococcus mu...
XP_010323898  78 RNQIPPrn----------lD--LY--PKLVKDH-VVIVLYVHNRPQYLQIVIDSLSRVEGISETLLIVSHDGYFEEMNKI 142 tomato
XP_009397224  87 RNKLPPWNM----------D--RF--PNLAKDH-TKIVLYVHNRPQYLRLVVSSLAAVEGISETMLIVSHDGYFAEMDRI 151 wild Malaysian ...
EHJ74167      38 RRLITEYNQeeki---sniE--TF--GPIKNNT-VVLVVTVHKLHESLKYLIASLSELDAIEETLLVFSHLTYDQELYDF 109 monarch butterfly
EHJ71219      12 kvLLKMLNCkqsv---tngN--KF--SSINNDS-PILIIQVHTDLEKLRYLILSLSQVDSVKNSLIIFSHSFYCSKINRL 83  monarch butterfly

Q9FT88       145 VES-IKFCQVKQIFSPYSPHIYRTSFPGVTLNDCK-----NKGDEAKGHCEGN--PDQYGNHRSPKIVSLKHHWWWMMNT 216 thale cress
Q69QZ8       154 VQT-ITFCQVKQIFAPYSPHLFPEAFPGVSSGDCQ-----GKDKAAEKHCQGD--PDQYGNHRSPRIVSLKHHWWWMMNT 225 Japanese rice
XP_002116702  81 VES-VQFCPVIQIFFPYSAQLHPDVFPGTDPRDCKrd--tPKELALVKKCLNAnyPDQFGHYREADYTMTKHHWWWKINF 157 Trichoplax adha...
XP_004990454 248 LDS-IDFMCVIRVFYPGSLQLNPDQFPGTDPNDCPrd--iSKEEALRIGCNNArnPDQYHHYREAQFTVIKHHWWWKLNF 324 Salpingoeca ros...
XP_004343299 233 IRSnLKFCRYVQIFMPHSMQLHPEAFPGQGTNDCPrd--lSKSDARALGCVNAefPDTYGHYREAPFAMIKHHWWWKANT 310 Capsaspora owcz...
CDJ03124     192 IAA-IRFVRFTQIFFPYSRQIFLNSFPGPDPRDCHt--------RGAKNCLNHewPDIAGNYRDARFAQVKHHWIWKLCF 262 Echinococcus mu...
XP_010323898 143 VEG-IKFCQVKQIFAPYSPHIFSNSFPGVSPRDCK-----DKDDPVEKQCEGt--PDQYGNHRSPTIVSLKHHWWWMMNT 214 tomato
XP_009397224 152 VQD-IRFCQAKQIFAPYSPHLFPDGFPGVSPGDCH-----DKDDPIVTKCNGTa--DQYGNHRSPRTVSLKHHWWWMMNT 223 wild Malaysian ...
EHJ74167     110 IQT-IDFCRVWQIFYPYTLQVYTDAFPGFSKNDCPtn--mKHKKAEALKCIGAqtPDVHGKYRQPSKAQEKHYWWWTANR 186 monarch butterfly
EHJ71219      84 IRS-IDFCKVMQIFYPYSLQLHPNEFPGVDPNDCNsykrrIKNAQKLSHCAK----------RDASITEHKQHWWWKANF 152 monarch butterfly

Q9FT88       217 VWDGLEETKGHEGHILFIEEDHFLFPNAYRNIQTLTRLKPAKCPDCFAANLAPSDVKS----------RGEGLESlvaeR 286 thale cress
Q69QZ8       226 VWDGLDETRDFDGHILFIEEDHYIFPNAYRNAQLLVDLKPSKCPQCYAINLAPSDVKA----------KGEGWESlvaeK 295 Japanese rice
XP_002116702 158 VFDQLNILKDYKGLVLLLEEDHYVAPDFLTIMKLLEQKRNSEYPNCDFLGLGSYNRHGsyshfkhkvaDYVAWAS----N 233 Trichoplax adha...
XP_004990454 325 VFDHMPVLKNHNGLKVLLEEDHYLAPDTIHMLLKTWRVAQEQKHTSDIIVLGDYDAGHgafa--gnvvHRQPWVS----T 398 Salpingoeca ros...
XP_004343299 311 VFDVLQVTRENNGPMLFLEEDHVLAPDALVAVMAATAARPRLCPSCQLVGIATYNPLEatidhkaataHTAAWLS----A 386 Capsaspora owcz...
CDJ03124     263 VINKMNISKSFNGQYILLEEDYIVLKDMLHVLSLAKKLNTSF----DIIALGSYENLQtyns--seilHETYWIS----S 332 Echinococcus mu...
XP_010323898 215 VWDGLTETRHHSGHILFIEEDHFIYPNAYRNMQLLTELKSKKCPDCYAANLAPSEVKS----------RGEGWESlvaeR 284 tomato
XP_009397224 224 VWDGMEETKGFSGHILFIEEDHYIYPNAYRNLQLLIGLKPMKCPECYAANLSPMDVNS----------IGEGWDMlvaeK 293 wild Malaysian ...
EHJ74167     187 VFEHLLSFNNQNGVVVFLEDDAFVLQDFLYMTVYMHKLTLSL-PQLEFIYLGLHKWSLendt---ygiDITTWDP----K 258 monarch butterfly
EHJ71219     153 VFEHVRLIRKHTGPFIFLEENNYVAPDLLIMFHCALE-TFNYFSHIEVLSFGGPLNVInmn-----llSVEPWRP----- 221 monarch butterfly

Q9FT88       287 MGNVGYSFNRSVWENIHQKAREFCFFDDYNWDITMWATV----FPSfgSPVYTLR-GPRtsAVHFGKC-GL----HqG-- 354 thale cress
Q69QZ8       296 MGNIGYAFNRTVWRKIHAKAKQFCTFDEYNWDITMWATV----YPSfgSPVYSLR-GPRrsAAHFGKC-GL----HqG-- 363 Japanese rice
XP_002116702 234 KNNMGMAMNRATFDKIKRCNNQFCRFDDYNWDWTIQSLSsk-cLNRp-LTILTMQ-APH--VFHAGECsGL----H-H-- 301 Trichoplax adha...
XP_004990454 399 KHNMGMALSRQLFDKIKQCARMFCEFDDYNWDWSLFAVSargcIDQmaIHALVMA-GQR--IQHLGVC-GV----H-S-- 467 Salpingoeca ros...
XP_004343299 387 QNNMGMVIDRAAWSSIKSCHRDFCTFDDYNWDWSLQYAAst-cVGS--LNILVLD-HPR--VVHIGTC-GAhayqH-S-- 456 Capsaspora owcz...
CDJ03124     333 KHNMGMAFTKNLFQKLEPYWKNFCIYDDYNWDWSLYFIDrv-cASEk-LRVLHFKnCGR--VFHTGSC-GL----H-N-- 400 Echinococcus mu...
XP_010323898 285 MGNVGYAFNRTVWRKIHNKAAGFCTFDDYNWDITMWSTV----YPSfgSPVYTLR-GSRtsAVHFGKC-GL----H-Q-- 351 tomato
XP_009397224 294 MGNVGYSFNRTVWRKIHTKAKEFCSFDEYNWDITMWATV----YPSfgTPVYTLR-GPRrsAAHFGKC-GL----H-Qgr 362 wild Malaysian ...
EHJ74167     259 QHSSVLAFDVSVWNSIIQHYDLFCEVDDASWSRSLLYISlnrrDNKr-FKVAYTT-IPR--ALKTTLC-SF----N-G-- 326 monarch butterfly
EHJ71219     222 PFDLGLAFNKTTWRKIFSYSSHYCMFDDSSWSYSMWNLFgn-fPKGy-VTMARFM-TPR--VLNTKEI--V----H-S-- 287 monarch butterfly

Q9FT88       355 -RGD---EgdC-IDNGVVN-IeVKET-----------------DKVVNIKEGW-------GvrvykhqA-------GYKA 397 thale cress
Q69QZ8       364 -QGL---SnvC-VDNGDAT-VqLDAI-----------------DKVPNIKANW-------PvhiikrqE-------GYQA 406 Japanese rice
XP_002116702 302 -KRF------C-KMEDTIT-A-IERSlsanm--------dylfPQTIGVTSQN-------Reir--rfA-------GVSR 347 Trichoplax adha...
XP_004990454 468 -AGK---D--C-SGTDAIE-R-AKRFnaana--------aqmfPQSLQVVTKT-------G-------Q-------APFV 509 Salpingoeca ros...
XP_004343299 457 -PGK---P--C-NPAQLMD-Q-LNALwnykkssmlhfaadgtpSESISLSSKG-------A-------M-------AVPR 506 Capsaspora owcz...
CDJ03124     401 -KGS---E--CdNVEASVV-G-VMERvarggg-----sdeglfPATLMVKMAT-------V-------Q-------RSAV 446 Echinococcus mu...
XP_010323898 352 -GHSrnlA--C-MDNGNVN-I-VVDEl----------------DKVANIKPEW-------EvrkydhqA-------GYQA 395 tomato
XP_009397224 363 gKSS---S--C-IDNGEARfQ-LDEI-----------------DKILNIKPDW-------K-------VhvvkkqsGYQA 404 wild Malaysian ...
EHJ74167     327 -FYE---S--C-NVEDNVV-N-ALRMqrhlk--------snlfPPYLEVYTHI-------Eled-defM-------FFDV 374 monarch butterfly
EHJ71219     288 -E----------------Q-K-FKEYvggfn-------tlnvfCKKLKAVFLFgpegvveR-------A-------HKCP 327 monarch butterfly

Q9FT88       398 GFEGwGGWGDDRDRHLC 414 thale cress
Q69QZ8       407 GFKGwGGWGDKRDQELC 423 Japanese rice
XP_002116702 348 PNGY-GGWGDIRDHKLC 363 Trichoplax adhaerens
XP_004990454 510 RAGY-GGWGDPRDVNLC 525 Salpingoeca rosetta
XP_004343299 507 PSPN-GGWGDHRDHALC 522 Capsaspora owczarzaki ATCC 30864
CDJ03124     447 P-PN-GGWGDARDRALC 461 Echinococcus multilocularis
XP_010323898 396 GFKGwGGWGDVRDHELC 412 tomato
XP_009397224 405 GFKGwGGWGDERDRELC 421 wild Malaysian banana
EHJ74167     375 LEGE-GGWNDPRDKALC 390 monarch butterfly
EHJ71219     328 PKGD-GAWNDLRDQLLC 343 monarch butterfly
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